4 research outputs found
Expression et caractérisation du récepteur hypophysaire de rat du facteur de libération de l'hormone de croissance ainsi que de ses isoformes
Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal
DRIVE: Data-driven Robot Input Vector Exploration
An accurate motion model is a fundamental component of most autonomous
navigation systems. While much work has been done on improving model
formulation, no standard protocol exists for gathering empirical data required
to train models. In this work, we address this issue by proposing Data-driven
Robot Input Vector Exploration (DRIVE), a protocol that enables characterizing
uncrewed ground vehicles (UGVs) input limits and gathering empirical model
training data. We also propose a novel learned slip approach outperforming
similar acceleration learning approaches. Our contributions are validated
through an extensive experimental evaluation, cumulating over 7 km and 1.8 h of
driving data over three distinct UGVs and four terrain types. We show that our
protocol offers increased predictive performance over common human-driven
data-gathering protocols. Furthermore, our protocol converges with 46 s of
training data, almost four times less than the shortest human dataset gathering
protocol. We show that the operational limit for our model is reached in
extreme slip conditions encountered on surfaced ice. DRIVE is an efficient way
of characterizing UGV motion in its operational conditions. Our code and
dataset are both available online at this link:
https://github.com/norlab-ulaval/DRIVE.Comment: 6 pages, 7 figures, submitted to 2024 IEEE International Conference
on Robotics and Automation (ICRA 2024
The 20S proteasome core, active within apoptotic exosome-like vesicles, induces autoantibody production and accelerates rejection
Autoantibodies to components of apoptotic cells, such as anti-perlecan antibodies, contribute to rejection in organ
transplant recipients. However, mechanisms of immunization to apoptotic components remain largely uncharacterized. We used large-scale proteomics, with validation by electron microscopy and biochemical methods, to compare
the protein profiles of apoptotic bodies and apoptotic exosome-like vesicles, smaller extracellular vesicles released
by endothelial cells downstream of caspase-3 activation. We identified apoptotic exosome-like vesicles as a central
trigger for production of anti-perlecan antibodies and acceleration of rejection. Unlike apoptotic bodies, apoptotic
exosome-like vesicles triggered the production of anti-perlecan antibodies in naĂŻve mice and enhanced anti-perlecan
antibody production and allograft inflammation in mice transplanted with an MHC (major histocompatibility
complex)–incompatible aortic graft. The 20S proteasome core was active within apoptotic exosome-like vesicles
and controlled their immunogenic activity. Finally, we showed that proteasome activity in circulating exosome-like
vesicles increased after vascular injury in mice. These findings open new avenues for predicting and controlling maladaptive humoral responses to apoptotic cell components that enhance the risk of rejection after transplantation