Clonidine in the management of uncontrolled hypertension

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Feasibility of tailored treatment based on risk stratification in patients with early rheumatoid arthritis

Introduction: Personalized medicine is the holy grail of medicine. The EULAR recommendations for the management of rheumatoid arthritis (RA) support differential treatment between patients with baseline characteristics suggestive of a non-poor prognosis (non-PP) or poor prognosis (PP) (presence of autoantibodies, a high inflammatory activity and damage on radiographs). We aimed to determine which prognostic risk groups benefit more from initial monotherapy or initial combination therapy. Methods: 508 patients were randomized t

Beneficial effect of labetalol in hypertensive patients with angina pectoris

Labetalol (Trandate; Alien &Hanbury) was administered to 17 hypertensive patients with angina pectoris, which had persisted despite blood pressure control on treatment including B-blocking agents. In comparison with placebo, labetalol significantly reduced the frequency and severity of attacks of angina pectoris, witnout further improvement in control of blood pressure at rest, during isotonic exercise or on pertormance of the cold pressor test. Labetalol significantly reduced blood pressure levels during isometric exercise but did not reduce the systolic pressure- heart rate product. Labetalol improved the angina without evidence of causing a reduction of cardiac work (and presumably oxygen consumption by the myocardium) in comparison with the other antihypertensive agents used in this study. A possible mechanism whereby labetalol increases myocardial blood supply in hypertensive patients with angina pectoris is by an increase in coronary pertusion due to its vasodilator action

Disease Flares during 10 Year Follow-up in Patients with Rheumatoid Arthritis Are Associated with Joint Damage Progression and Disability

Pathophysiology and treatment of rheumatic disease

Erosions in the Foot at Baseline Are Predictive of Orthopedic Shoe Use after 10 Years of Treat to Target Therapy

Pathophysiology and treatment of rheumatic disease

Erosions in the Foot at Baseline Are Predictive of Orthopedic Shoe Use after 10 Years of Treat to Target Therapy

Pathophysiology and treatment of rheumatic disease