8,843 research outputs found
A Crucial Role of IL-17 and IFN-γ during Acute Rejection of Peripheral Nerve Xenotransplantation in Mice
Nerve injuries causing segmental loss require nerve grafting. However, autografts and allografts have limitations for clinical use. Peripheral nerve xenotransplantation has become an area of great interest in clinical surgery research as an alternative graft strategy. However, xenotransplant rejection is severe with cellular immunity, and Th1 cells play an important role in the process. To better understand the process of rejection, we used peripheral nerve xenografts from rats to mice and found that mononuclear cells expressing IFN-γ and IL-17 infiltrated around the grafts, and IFN-γ and IL-17 producing CD4+ and CD8+ T cells increased during the process of acute rejection. The changes of IL-4 level had no significant difference between xenotransplanted group and sham control group. The rejection of xenograft was significantly prevented after the treatment of IL-17 and IFN-γ neutralizing antibodies. These data suggest that Th17 cells contribute to the acute rejection process of peripheral nerve xenotransplant in addition to Th1 cells
Testing Technicolor Models via Top Quark Pair Production in High Energy Photon Collisions
Pseudo-Goldstone boson contributions to production rates in
technicolor models with and without topcolor at the TeV
photon colliders and hadron colliders are reviewed. For reasonable ranges of
the parameters, the contributions are large enough to be experimentally
observable. Models with topcolor, without topcolor and the MSSM with
can be experimentally distinguished.Comment: Talk given by H.Y. Zhou at the III International Conference on
Hyperons,Charm and Beauty Hadrons,Genova,Italy,June 30-July 3 199
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