The Online Bookstore

Nowadays, the network plays an import role in people’s life. In the process of the improvement of the people’s living standard, people’s demands of the life’s quality and efficiency is more higher, the traditional bookstore’s inconvenience gradually emerge, and the online bookstore has gradually be used in public. The online bookstore is a revolution of book industry. The traditional bookstores’ operation time, address and space is limited, so the types of books and books to find received a degree of restriction. But the online bookstore broke the management mode of traditional bookstore, as long as you have a computer, you can buy the book anywhere, saving time and effort, shortening the time of book selection link effectively. The online bookstore system based on the principle of provides convenience and service to people

Med andre ord – om forkyndelse og helliggørelse

Nowadays, the network plays an import role in people’s life. In the process of the improvement of the people’s living standard, people’s demands of the life’s quality and efficiency is more higher, the traditional bookstore’s inconvenience gradually emerge, and the online bookstore has gradually be used in public. The online bookstore is a revolution of book industry. The traditional bookstores’ operation time, address and space is limited, so the types of books and books to find received a degree of restriction. But the online bookstore broke the management mode of traditional bookstore, as long as you have a computer, you can buy the book anywhere, saving time and effort, shortening the time of book selection link effectively. The online bookstore system based on the principle of provides convenience and service to people

Effect of Radius on Load/Strain Distribution between Ulna and Radius: Experimental and Numberical Analyses

Computational Infrastructure and Informatics Poster SessionIt has been hypothesized that osteocytes are stimulated by local strain distribution within the bone subjected to mechanical loadings. This collaborative research project between bone biologists and mechanical engineers is attempting to identify local strain fields around osteocytes that can account for their behavior in response to loading. Using CT images we have built and conducted an extensive finite element study of the mouse forearm. Our model incorporates many components of forearm anatomy not previously included in these models such as the radius and marrow cavities. The results of the current research will shed light on how bone perceives mechanical load and the pathway whereby a physical load is transduced into a biochemical signal that eventually results in new bone formation. The study will help in developing new treatments for bone diseases such as osteoporosis

Improved bioenergy value of residual rice straw by increased lipid levels from upregulation of fatty acid biosynthesis

BackgroundRice (Oryza sativa) straw is a common waste product that represents a considerable amount of bound energy. This energy can be used for biogas production, but the rate and level of methane produced from rice straw is still low. To investigate the potential for an increased biogas production from rice straw, we have here utilized WRINKLED1 (WRI1), a plant AP2/ERF transcription factor, to increase triacylglycerol (TAG) biosynthesis in rice plants. Two forms of Arabidopsis thaliana WRI1 were evaluated by transient expression and stable transformation of rice plants, and transgenic plants were analyzed both for TAG levels and biogas production from straw.ResultsBoth full-length AtWRI1, and a truncated form lacking the initial 141 amino acids (including the N-terminal AP2 domain), increased fatty acid and TAG levels in vegetative and reproductive tissues of Indica rice. The stimulatory effect of the truncated AtWRI1 was significantly lower than that of the full-length protein, suggesting a role for the deleted AP2 domain in WRI1 activity. Full-length AtWRI1 increased TAG levels also in Japonica rice, indicating a conserved effect of WRI1 in rice lipid biosynthesis. The bio-methane production from rice straw was 20% higher in transformants than in the wild type. Moreover, a higher producing rate and final yield of methane was obtained for rice straw compared with rice husks, suggesting positive links between methane production and a high amount of fatty acids.ConclusionsOur results suggest that heterologous WRI1 expression in transgenic plants can be used to improve the metabolic potential for bioenergy purposes, in particular methane production

Entire Peroxidation Reaction System of Myeloperoxidase Correlates with Progressive Low-Density Lipoprotein Modifications via Reactive Aldehydes in Atherosclerotic Patients with Hypertension

Background/Aims: Reactive oxygen species (ROS) contribute to the dysfunction of serum lipoproteins, which triggers lipid metabolism abnormalities in the development of atherosclerosis and hypertension. Myeloperoxidase (MPO) is involved in ROS modifications, triggering lipid peroxidation and aldehyde formation. However, the relationship between the entirety of the MPO reaction system and oxidative modification of serum lipoproteins in atherosclerotic patients with hypertension remains unclear. Methods: We measured MPO activity (peroxidation and chlorination), 4-hydroxynonenal-modified low-density lipoprotein (HNE-LDL), malondialdehyde-modified low-density lipoprotein (MDA-LDL), H2O2, reduced glutathione (GSH), and oxidized glutathione (GSSG) using a corresponding commercial kit in atherosclerotic patients with hypertension and healthy participants. We used Spearman’s correlation analysis to investigate the correlation between MPO activity and the levels of these oxidative and anti-oxidative stress-related indices and performed response surface regression to investigate the relationship between the MPO reaction system and the levels of HNE-LDL, MDA-LDL, and the GSH/GSSG ratio. Results: Our results showed no association between the levels of MPO peroxidation activity, MPO chlorination activity, H2O2, and Cl- and those of HNE-LDL, MDA-LDL, GSH, and GSSG, and the GSH/GSSG ratio in healthy participants. In addition, no effects of the peroxidation reaction system of MPO (PRSM) and the chlorination reaction system of MPO (CRSM) on GSH/GSSG were found in this investigation. However, we found that the PRSM rather than the CRSM correlated with progressive low-density lipoprotein (LDL) modifications by HNE-LDL and MDA-LDL in atherosclerotic patients with hypertension. Conclusion: The PRSM rather than the CRSM correlated with progressive LDL modifications via reactive aldehydes in atherosclerotic patients with hypertension. Further investigation is warranted to evaluate whether the PRSM may serve as a potential index for monitoring LDL function in atherosclerosis and hypertension

A heterozygous moth genome provides insights into herbivory and detoxification

How an insect evolves to become a successful herbivore is of profound biological and practical importance. Herbivores are often adapted to feed on a specific group of evolutionarily and biochemically related host plants1, but the genetic and molecular bases for adaptation to plant defense compounds remain poorly understood2. We report the first whole-genome sequence of a basal lepidopteran species, Plutella xylostella, which contains 18,071 protein-coding and 1,412 unique genes with an expansion of gene families associated with perception and the detoxification of plant defense compounds. A recent expansion of retrotransposons near detoxification-related genes and a wider system used in the metabolism of plant defense compounds are shown to also be involved in the development of insecticide resistance. This work shows the genetic and molecular bases for the evolutionary success of this worldwide herbivore and offers wider insights into insect adaptation to plant feeding, as well as opening avenues for more sustainable pest management.Minsheng You … Simon W Baxter … et al

Self-Adaptive Telemedicine Specialist Recommendation Considering Specialist Activity and Patient Feedback

Purpose: With the rapid development of medical informatization, information overload and asymmetry have become major obstacles that limit patients’ ability to find appropriate telemedicine specialists. Although doctor recommendation methods have been proposed, they fail to address data sparsity and cold-start issues, and electronic medical records (EMRs), patient preferences, potential interest of service providers and the changes over time are largely under-explored. Therefore, this study develops a self-adaptive telemedicine specialist recommendation method that incorporates specialist activity and patient utility feedback from the perspective of privacy protection to fill the research gaps. Methods: First, text vectorization, view similarity and probabilistic topic model are used to construct the patient and specialist feature models based on patients’ EMRs and specialists’ long- and short-term knowledge backgrounds, respectively. Second, the recommended specialist candidate set and recommendation index are obtained based on the similarity between patient features. Then, the specialist long-term knowledge feature model is used to update the newly registered specialist recommendation index and the recommended specialist candidate set to overcome the data sparsity and cold-start issues, and the specialist short-term knowledge feature model is adopted to extend the recommended specialist candidate set at the semantic level. Finally, we introduce the specialists’ activity and patients’ perceived utility feedback mechanism to construct a closed-loop adjusted and optimized specialist recommendation method. Results: An empirical study was conducted integrating EMRs of telemedicine patients from the National Telemedicine Center of China and specialists’ profiles and ratings from an online healthcare platform. The proposed method successfully recommended relevant and active telemedicine specialists to the target patient, and increased the recommended opportunities for newly registered specialists to some extent. Conclusions: The proposed method emphasizes the adaptability and acceptability of the recommended results while ensuring their accuracy and relevance. Specialists’ activity and patients’ perceived utility jointly contribute to the acceptability of recommended results, and the recommendation strategy achieves the organic fusion of the two. Several comparative experiments demonstrate the effectiveness and operability of the hybrid recommendation strategy under the premise of data sparsity and privacy protection, enabling effective matching of patients’ demand and service providers’ capabilities, and providing beneficial insights for data-driven telemedicine services

Experimental Study on Simultaneous Desulfurization and Denitrification by DBD Combined with Wet Scrubbing

A dielectric barrier discharge (DBD) reactor combined with a wet scrubbing tower was used to carry out an experimental study on desulfurization and denitrification. The effects of the packing type, packing height, spray density, mass fraction of the NaOH solution, discharge power in the DBD reactor, and simulated flue gas flow rate on the desulfurization and denitrification efficiency were analyzed, along with the influence weight of each factor, using orthogonal testing. The experimental results showed that SO2 was easily absorbed by the scrubbing solution, while the desulfurization efficiency remained at a high level (97–100%) during the experiment. The denitration efficiency was between 12 and 96% under various operating conditions. Denitration is the key problem in this system. The influence weights of the DBD power, simulated flue gas flow rate, mass fraction of the NaOH solution, spray density, packing type, and packing height on the denitration efficiency were 56.96%, 18.02%, 11.52%, 5.02%, 4.33%, and 4.16%, respectively. This paper can provide guidance to optimize the desulfurization and denitrification efficiency of this DBD reactor combined with a wet scrubbing system