An Experimental Study on the Burning Behavior of Fabric used Indoor

AbstractFabrics used indoor has a major impact on the development and spread of indoor fires and fire hazards because of its easy ignition, fast burning speed and the rapid spread rate. In this paper, the burning behavior of five kinds of fabrics used indoor such as cotton woven, jeans, woollen sweater, linen rope and sponge, were studied by means of the cone calorimeter. The ignition time, the heat release rate, the mass loss rate, the yield of CO and the smoke production rate of the five kinds of fabrics used indoor were analyzed and compared at different external heat flux conditions with the specific experimental data and image. Our results indicated that: with the increase of the heat flux, five kinds of fabrics were more and more to be ignited; in higher heat flux condition, average heat release rate and the peak mass loss rate were higher; In lower heat flux condition, due to the incomplete combustion, smoke production rate and the yield of CO were higher; and the effect of the density of the structure and moisture content to burning behavior of fabrics can’t be ignored. Fire risk order of five kinds of fabrics is: woollen fabrics> sponge fabrics> cotton fabrics> linen fabrics

Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery.

Neurite initiation is the first step in neuronal development and occurs spontaneously in soft tissue environments. Although the mechanisms regulating the morphology of migratory cells on rigid substrates in cell culture are widely known, how soft environments modulate neurite initiation remains elusive. Using hydrogel cultures, pharmacologic inhibition, and genetic approaches, we reveal that paxillin-linked endocytosis and adhesion are components of a bistable switch controlling neurite initiation in a substrate modulus-dependent manner. On soft substrates, most paxillin binds to endocytic factors and facilitates vesicle invagination, elevating neuritogenic Rac1 activity and expression of genes encoding the endocytic machinery. By contrast, on rigid substrates, cells develop extensive adhesions, increase RhoA activity and sequester paxillin from the endocytic machinery, thereby delaying neurite initiation. Our results highlight paxillin as a core molecule in substrate modulus-controlled morphogenesis and define a mechanism whereby neuronal cells respond to environments exhibiting varying mechanical properties

Intrinsically stretchable and transparent thin-film transistors based on printable silver nanowires, carbon nanotubes and an elastomeric dielectric.

Thin-film field-effect transistor is a fundamental component behind various mordern electronics. The development of stretchable electronics poses fundamental challenges in developing new electronic materials for stretchable thin-film transistors that are mechanically compliant and solution processable. Here we report the fabrication of transparent thin-film transistors that behave like an elastomer film. The entire fabrication is carried out by solution-based techniques, and the resulting devices exhibit a mobility of ∼30 cm(2) V(-1) s(-1), on/off ratio of 10(3)-10(4), switching current >100 μA, transconductance >50 μS and relative low operating voltages. The devices can be stretched by up to 50% strain and subjected to 500 cycles of repeated stretching to 20% strain without significant loss in electrical property. The thin-film transistors are also used to drive organic light-emitting diodes. The approach and results represent an important progress toward the development of stretchable active-matrix displays

Semantic-Aware Local-Global Vision Transformer

Vision Transformers have achieved remarkable progresses, among which Swin Transformer has demonstrated the tremendous potential of Transformer for vision tasks. It surmounts the key challenge of high computational complexity by performing local self-attention within shifted windows. In this work we propose the Semantic-Aware Local-Global Vision Transformer (SALG), to further investigate two potential improvements towards Swin Transformer. First, unlike Swin Transformer that performs uniform partition to produce equal size of regular windows for local self-attention, our SALG performs semantic segmentation in an unsupervised way to explore the underlying semantic priors in the image. As a result, each segmented region can correspond to a semantically meaningful part in the image, potentially leading to more effective features within each of segmented regions. Second, instead of only performing local self-attention within local windows as Swin Transformer does, the proposed SALG performs both 1) local intra-region self-attention for learning fine-grained features within each region and 2) global inter-region feature propagation for modeling global dependencies among all regions. Consequently, our model is able to obtain the global view when learning features for each token, which is the essential advantage of Transformer. Owing to the explicit modeling of the semantic priors and the proposed local-global modeling mechanism, our SALG is particularly advantageous for small-scale models when the modeling capacity is not sufficient for other models to learn semantics implicitly. Extensive experiments across various vision tasks demonstrates the merit of our model over other vision Transformers, especially in the small-scale modeling scenarios

HIV-1 variants with a single-point mutation in the gp41 pocket region exhibiting different susceptibility to HIV fusion inhibitors with pocket- or membrane-binding domain

AbstractEnfuvirtide (T20), the first FDA-approved peptide HIV fusion/entry inhibitor derived from the HIV-1 gp41 C-terminal heptad-repeat (CHR) domain, is believed to share a target with C34, another well-characterized CHR-peptide, by interacting with the gp41 N-terminal heptad-repeat (NHR) to form six-helix bundle core. However, our previous studies showed that T20 mainly interacts with the N-terminal region of the NHR (N-NHR) and lipid membranes, while C34 mainly binds to the NHR C-terminal pocket region. But so far, no one has shown that C34 can induce drug-resistance mutation in the gp41 pocket region. In this study, we constructed pseudoviruses in which the Ala at the position of 67 in the gp41 pocket region was substituted with Asp, Gly or Ser, respectively, and found that these mutations rendered the viruses highly resistant to C34, but sensitive to T20. The NHR-peptide N36 with mutations of A67 exhibited reduced anti-HIV-1 activity and decreased α-helicity. The stability of six-helix bundle formed by C34 and N36 with A67 mutations was significantly lower than that formed by C34 and N36 with wild-type sequence. The combination of C34 and T20 resulted in potent synergistic anti-HIV-1 effect against the viruses with mutations in either N- or C-terminal region in NHR. These results suggest that C34 with a pocket-binding domain and T20 containing the N-NHR- and membrane-binding domains inhibit HIV-1 fusion by interacting with different target sites and the combinatorial use of C34 and T20 is expected to be effective against HIV-1 variants resistant to HIV fusion inhibitors

How tyramine β-hydroxylase controls the production of octopamine, modulating the mobility of beetles

Biogenic amines perform many kinds of important physiological functions in the central nervous system (CNS) of insects, acting as neuromodulators, neurotransmitters, and neurohormones. The five most abundant types of biogenic amines in invertebrates are dopamine, histamine, serotonin, tyramine, and octopamine (OA). However, in beetles, an important group of model and pest insects, the role of tyramine beta-hydroxylase (T beta H) in the OA biosynthesis pathway and the regulation of behavior remains unknown so far. We therefore investigated the molecular characterization and spatiotemporal expression profiles of T beta H in red flour beetles (Triboliun castaneum). Most importantly, we detected the production of OA and measured the crawling speed of beetles after dsTcT beta H injection. We concluded that TcT beta H controls the biosynthesis amount of OA in the CNS, and this in turn modulates the mobility of the beetles. Our new results provided basic information about the key genes in the OA biosynthesis pathway of the beetles, and expanded our knowledge on the physiological functions of OA in insects