7 research outputs found
MotionBEV: Attention-Aware Online LiDAR Moving Object Segmentation with Bird's Eye View based Appearance and Motion Features
Identifying moving objects is an essential capability for autonomous systems,
as it provides critical information for pose estimation, navigation, collision
avoidance, and static map construction. In this paper, we present MotionBEV, a
fast and accurate framework for LiDAR moving object segmentation, which
segments moving objects with appearance and motion features in the bird's eye
view (BEV) domain. Our approach converts 3D LiDAR scans into a 2D polar BEV
representation to improve computational efficiency. Specifically, we learn
appearance features with a simplified PointNet and compute motion features
through the height differences of consecutive frames of point clouds projected
onto vertical columns in the polar BEV coordinate system. We employ a
dual-branch network bridged by the Appearance-Motion Co-attention Module (AMCM)
to adaptively fuse the spatio-temporal information from appearance and motion
features. Our approach achieves state-of-the-art performance on the
SemanticKITTI-MOS benchmark. Furthermore, to demonstrate the practical
effectiveness of our method, we provide a LiDAR-MOS dataset recorded by a
solid-state LiDAR, which features non-repetitive scanning patterns and a small
field of view
Chemotherapy-Induced Ca2+ Release Stimulates Breast Cancer Stem Cell Enrichment
Breast cancer stem cells (BCSCs) play a critical role in tumor recurrence and metastasis. Exposure of breast cancer cells to chemotherapy leads to an enrichment of BCSCs. Here, we find that chemotherapy induces the expression of glutathione S-transferase omega 1 (GSTO1), which is dependent on hypoxia-inducible factor 1 (HIF-1) and HIF-2. Knockdown of GSTO1 expression abrogates carboplatin-induced BCSC enrichment, decreases tumor initiation and metastatic capacity, and delays tumor recurrence after chemotherapy. GSTO1 interacts with the ryanodine receptor RYR1 and promotes calcium release from the endoplasmic reticulum. Increased cytosolic calcium levels activate PYK2 → SRC → STAT3 signaling, leading to increased expression of pluripotency factors and BCSC enrichment. HIF inhibition blocks chemotherapy-induced GSTO1 expression and BCSC enrichment. Combining HIF inhibitors with chemotherapy may improve clinical outcome in breast cancer
Prediction of Novel High-Pressure Structures of Magnesium Niobium Dihydride
On
the basis of a combination of the particle-swarm optimization technique
and density functional theory (DFT), we explore the crystal structures
of MgH<sub>2</sub>, NbH<sub>2</sub>, and MgNbH<sub>2</sub> under high
pressure. The enthalpy–pressure (<i>H</i>–<i>P</i>) diagrams indicate that the structural transition sequence
of MgH<sub>2</sub> is α → γ → δ →
ε → ζ and that NbH<sub>2</sub> transforms from
the <i>Fm</i>3Ì…<i>m</i> phase to the <i>Pnma</i> phase at 47.80 GPa. However, MgNbH<sub>2</sub> is unstable
when the pressure is too low or too high. Two novel MgNbH<sub>2</sub> structures, the hexagonal <i>P</i>6Ì…<i>m</i>2 phase and the orthorhombic <i>Cmcm</i> phase, are discovered,
which are stable in the pressure ranges of 13.24–128.27 GPa
and 128.27–186.77 GPa, respectively. The <i>P</i>6̅<i>m</i>2 phase of MgNbH<sub>2</sub> consists of
alternate layers of polymetric NbH<sub>6</sub> and MgH<sub>6</sub> triangular prisms, while the <i>Cmcm</i> phase contains
distorted MgH<sub>6</sub> trigonal prisms. The calculated elastic
constants and phonon dispersions confirm that both phases are mechanically
and dynamically stable. The analyses of density of states (DOS), electron
localization function (ELF), and Bader charge demonstrate that a combination
of ionic and metallic bonds exist in both <i>P</i>6Ì…<i>m</i>2 and <i>Cmcm</i> phases. We hope the newly predicted
magnesium niobium dihydrides with desirable electronic properties
will promote future experimental and theoretical studies on mixed
main group-transition metal hydrides
HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells
Prediction of Stable Ruthenium Silicides from First-Principles Calculations: Stoichiometries, Crystal Structures, and Physical Properties
We present results of an unbiased
structure search for stable ruthenium
silicide compounds with various stoichiometries, using a recently
developed technique that combines particle swarm optimization algorithms
with first-principles calculations. Two experimentally observed structures
of ruthenium silicides, RuSi (space group <i>P</i>2<sub>1</sub>3) and Ru<sub>2</sub>Si<sub>3</sub> (space group <i>Pbcn</i>), are successfully reproduced under ambient pressure conditions.
In addition, a stable RuSi<sub>2</sub> compound with β-FeSi<sub>2</sub> structure type (space group <i>Cmca</i>) was found.
The calculations of the formation enthalpy, elastic constants, and
phonon dispersions demonstrate the <i>Cmca</i>-RuSi<sub>2</sub> compound is energetically, mechanically, and dynamically
stable. The analysis of electronic band structures and densities of
state reveals that the <i>Cmca</i>-RuSi<sub>2</sub> phase
is a semiconductor with a direct band gap of 0.480 eV and is stabilized
by strong covalent bonding between Ru and neighboring Si atoms. On
the basis of the Mulliken overlap population analysis, the Vickers
hardness of the <i>Cmca</i> structure RuSi<sub>2</sub> is
estimated to be 28.0 GPa, indicating its ultra-incompressible nature
Ab Initio Search for Global Minimum Structures of Pure and Boron Doped Silver Clusters
The global minimum structures of
pure and boron doped silver clusters
up to 16 atoms are determined through ab initio calculations and unbiased
structure searching methods. The structural and electronic properties
of neutral, anionic, and cationic Ag<sub><i>n</i></sub>B
(<i>n</i> ≤ 15) and Ag<sub><i>n</i></sub>B<sub>2</sub> (<i>n</i> ≤ 14) clusters are much
distinct from those of the corresponding pure silver. Considering
that Ag and B possess one and three valence electrons, respectively,
both the single and the double boron-atom doped silver clusters with
even number of valence electrons are more stable than those with odd
number of electrons, a feature also observed in the pure silver clusters.
We demonstrate that the species with a valence count of 8 and 14 appear
to be magic numbers with enhanced stability irrespective of component
or the charged state. A new putative global minimum structure of Ag<sub>13</sub><sup>–</sup> cluster, with high symmetry of <i>C</i><sub>2<i>v</i></sub>, is unexpectedly observed
as the ground state, which is lower in energy than the previous suggested
bilayer structure