Adiponectinemia Is Associated with Uricemia but Not with Proinflammatory Status in Women with Metabolic Syndrome

Metabolic syndrome (MS) is a cluster of glucose intolerance, hypertension, and dyslipidemia with visceral fat accumulation. This study was undertaken to assess which components of metabolic syndrome (MS), including uric acid and proinflammatory markers, are related to adiponectin levels in overweight and obese women with MS. Ninety-one women (60 with MS and 31 controls) were assessed in relation to classical and inflammatory parameters of MS. In comparison to controls, patients with MS showed significant differences in parameters that are typically associated with MS and in inflammatory markers. Fibrinogen, CRP, and C3 were positively, whereas albumin was inversely correlated with abdominal adiposity and insulin resistance. Adiponectin was inversely correlated with waist circumference and uric acid levels. Activities of adiponectin and proinflammatory markers are not correlated in overweight and obese women with MS. In addition to abdominal adiposity, uric acid may be implicated in a decrease of adiponectin in MS patients

Análise do perfil epidemiológico de nascimentos pré-termo na UBS Novo Bandeirantes, nos anos de 2012 a 2019: Analysis of the epidemiological profile of preterm births at UBS Novo Bandeirantes, from 2012 to 2019

A prematuridade é definida como nascimento com idade gestacional abaixo de 36 semanas e 6 dias, considerada como um problema com diversas etiologias e encontra-se em crescimento no país, portanto compreender melhor suas causas, favorece na construção em melhores estratégias a fim de preveni-la. Assim, o hodierno estudo teve como objetivo os fatores sociodemográficos e gestacionais associados ao nascimento pré-termo dos recém-nascidos da área de abrangência de uma Unidade Básica de Saúde no Norte do Paraná. Trata-se de um estudo epidemiológico de caráter quantitativo, transversal, utilizando dados de 687 nascidos vivos disponibilizados pelo SINASC. Os dados foram organizados no Software Microsoft Excel 2013 e posteriormente processados no programa Epi-Info, versão 7.2.4.0, foram analisadas as associações entre as variáveis sociodemográficas e gestacionais pela razão dos produtos cruzados, razão de prevalência, com intervalo de confiança de 95% e o nível de significância adotado foi de p<0,05. O estudo verificou que início tardio e a adesão incorreta do pré-natal, baixo peso ao nascer e Apgar < 7 são fatores associados à nascimentos pré-termo. Portanto o nascimento de pré-termo está diretamente relacionado às variáveis sociodemográficas e gestacionais na qual a mãe está inserida, refletindo na assistência primária de saúde e a necessidade de intervenções e orientações a cerca de evitar tais riscos trazidos pela prematuridade, assim como a diminuição das taxas de nascimento pré-termo

Influence of Insulin Resistance and TNF- α

The aim of this study was to evaluate the involvement of TNF-α and insulin resistance (IR) in the inflammatory process, oxidative stress, and disease activity in patients with rheumatoid arthritis (RA). This cross-sectional study included 270 subjects (control group, n=97) and RA patients (n=173). RA patients were divided into four groups: the first group without IR and not using antitumor necrosis factor-α (TNF-) (G1, IR− TNF−); the second group without IR and using anti-TNF-α (G2, IR- TNF+); the third group with IR and not using anti-TNF-α (G3, IR+ TNF-); and the fourth group with IR and using anti-TNF-α (G4, IR+ TNF+). G3 and G4 had higher (p<0.05) advanced oxidation protein products (AOPPs) and oxidative stress index (OSI) compared to G1. G4 group presented higher (p<0.05) AOPPs and OSI than G2. TRAP was significantly lower in G3 compared to G1. Plasma TNF-α levels were significantly higher in G4 and G2 compared to G1 (p<0.0001) and G3 (p<0.0001 and p<0.01, resp.). The presence of insulin resistance was robustly associated with both oxidative stress and TNF-α levels. More studies are warranted to verify if IR can be involved in therapeutic failure with TNF-α inhibitors. This trial is registered with Brazilian Clinical Trials Registry Register number RBR-2jvj92

FOXP3 variants are independently associated with transforming growth factor Β1 plasma levels in female patients with inflammatory bowel disease

Objective: The aim of this study was to evaluate the association of -924 G&gt;A (rs2232365) and -3279 C&gt;A (rs3761548) FOXP3 variants with IBD susceptibility, clinical and endoscopic activity, and IL-10 and TGF-β1 plasma levels. Method: The study included&nbsp;110&nbsp;IBD female patients, 60&nbsp;with Ulcerative Colitis (UC) and 50&nbsp;with Crohn's Disease (CD), and 154&nbsp;female controls. FOXP3 variants were determined with Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). Plasma levels of IL-10 and TGF-β1 were determined using immunofluorimetric assay. Results: AA genotype of rs2232365 and rs3761548 was associated with CD (OR&nbsp;=&nbsp;3.147, 95%&nbsp;CI&nbsp;1.015–9.758, p&nbsp;=&nbsp;0.047) and UC (OR&nbsp;=&nbsp;3.221, 95%&nbsp;CI&nbsp;1.050–9.876, p&nbsp;=&nbsp;0.041) susceptibility, respectively. However, were not associated with TGF-β1 and IL-10 levels, and endoscopic/clinical activity disease. GAGA haplotype was associated with IBD (OR&nbsp;=&nbsp;4.003, 95%&nbsp;CI&nbsp;1.100–14.56, p&nbsp;=&nbsp;0.035) and UC susceptibility (OR&nbsp;=&nbsp;6.107, 95%&nbsp;CI&nbsp;1.609–23.18, p&nbsp;=&nbsp;0.008). In addition, IBD patients with the GAGA haplotype had lower TGF-β1 levels (p&nbsp;=&nbsp;0.041). Moreover, G/C haplotype (dominant model) had a protective effect of&nbsp;60% in CD susceptibility and lower Endoscopic Severity Index. Conclusions: These results suggest that FOXP3 variants could exert a role in the Treg, which could be one of the factors involved in the susceptibility and pathogenesis of IBD

Adiponectinemia Is Associated with Uricemia but Not with Proinflammatory Status in Women with Metabolic Syndrome

Metabolic syndrome (MS) is a cluster of glucose intolerance, hypertension, and dyslipidemia with visceral fat accumulation. This study was undertaken to assess which components of metabolic syndrome (MS), including uric acid and proinflammatory markers, are related to adiponectin levels in overweight and obese women with MS. Ninety-one women (60 with MS and 31 controls) were assessed in relation to classical and inflammatory parameters of MS. In comparison to controls, patients with MS showed significant differences in parameters that are typically associated with MS and in inflammatory markers. Fibrinogen, CRP, and C3 were positively, whereas albumin was inversely correlated with abdominal adiposity and insulin resistance. Adiponectin was inversely correlated with waist circumference and uric acid levels. Activities of adiponectin and proinflammatory markers are not correlated in overweight and obese women with MS. In addition to abdominal adiposity, uric acid may be implicated in a decrease of adiponectin in MS patients

Metabolic syndrome components are associated with oxidative stress in overweight and obese patients

ABSTRACT Objective: The aim of this study is to evaluate the influence of the body mass index (BMI) and the metabolic syndrome (MetS) parameters on oxidative and nitrosative stress in overweight and obese subjects. Subjects and methods: Individuals were divided into three groups: the control group (G1, n = 131) with a BMI between 20 and 24.9 kg/m2, the overweight group (G2, n = 120) with a BMI between 25 and 29.9 kg/m2 and the obese group (G3, n = 79) with a BMI ≥ 30 kg/m2. Results: G3 presented higher advanced oxidation protein products (AOPPs) in relation to G1 and G2 (p = 0.001 and p = 0.011, respectively) whereas G2 and G3 had lower levels of nitric oxide (NO) (p = 0.009 and p = 0.048, respectively) compared to G1. Adjusted for the presence of MetS to evaluate its influence, the levels of AOPPs did not differ between the groups, whereas NO remained significantly lower. Data adjusted by the BMI showed that subjects with higher triacylglycerol levels had higher AOPPs (p = 0.001) and decreased total radical-trapping antioxidant parameter/uric Acid (p = 0.036). Subjects with lower high-density lipoprotein (HDL) levels and patients with higher blood pressure showed increased AOPPs (p = 0.001 and p = 0.034, respectively) and lower NO levels (p = 0.017 and p = 0.043, respectively). Subjects who presented insulin resistance had higher AOPPs (p = 0.024). Conclusions: Nitrosative stress was related to BMI, and protein oxidation and nitrosative stress were related to metabolic changes and hypertension. MetS components were essential participants in oxidative and nitrosative stress in overweight and obese subjects

Association between vitamin D deficiency, adiposity and solar exposure in participants with arterial hypertension and diabetes mellitus

Currently, several studies have shown a relationship between vitamin D deficiency and type 2 diabetes mellitus, obesity and hypertension. The major cause of vitamin D deficiency is the lack of adequate sun exposure. The objective of the study was to evaluate serum vitamin D level and to verify its association with vitamin D ingestion, body composition and solar exposure in patients participating in the Hypertension and Diabetes System in Cascavel, PR. A total of 304 adult and elder patients from both genders participated in the study. Demographic and anthropometric data, lifestyle, presence of previous diseases, dietary and serum levels of vitamin D were evaluated. We used the chi square test for association verification and compliance and the Kruskal-Wallis test to compare medians between variables. It was verified serum 25-hydroxyvitamin D (25(OH)D) deficiency (&lt;20ng/mL) in 52.6%, overweight and obesity in 73.4%, increase in abdominal circumference in 77.6% and in body fat percentage in 95.6% of the patients. There was no association between ingestion and serum vitamin D levels. Significant association was found between abdominal circumference (p</p

Fish Oil N-3 Fatty Acids Increase Adiponectin and Decrease Leptin Levels in Patients with Systemic Lupus Erythematosus

Cardiovascular disease (CVD) has emerged as an important cause of death in patients with systemic lupus erythematosus (SLE). Reduced adiponectin and elevated leptin levels may contribute to CVD in SLE patients. The purpose of this study was to verify the effects of fish oil (FO) on adiponectin and leptin in patients with SLE. Biochemical and disease activity analysis were performed. Patients with SLE were divided in two groups: patients who used fish oil for four months and patients who did not use fish oil. Patients with SLE who used FO had a significant decrease in SLE disease activity index (SLEDAI) score (p ˂ 0.023) in relation to baseline. SLE patients who used fish oil had increased adiponectin levels (p ˂ 0.026) and decreased leptin levels (p ˂ 0.024) compared to baseline values, whereas there were no differences in adiponectin and leptin levels in patients with SLE who did not use fish oil. In conclusion, the findings of increased serum adiponectin an decreased leptin levels after 120 days in the fish oil group, reinforce the importance of evaluating prospective studies of fish and fish oil fish ingestion on these adipokines in an attempt to decrease cardiovascular risk factors in patients with SLE