A Novel Scheme for Material Updating in Source Distribution Optimization of Magnetic Devices using Sensitivity Analysis

A novel material updating scheme, which does not require intermediate states of a material used, is presented for source distribution optimization problems. A mutation factor to determine a degree of topological change in the next design stage on the basis of a current layout accelerates the convergence of an objective function. Easy implementation and fast convergence of the scheme are verified using two MRI design problems where current and permanent magnet distributions have been optimized, respectively

TRIAD - Preliminary design of an operational earth resources survey system. 1969 summer faculty fellowship program in engineering systems design

TRIAD, preliminary design of operational earth resources survey syste

Partnering with Medicaid to Advance and Sustain the Goals of the Child Welfare System

The purpose of this paper is to serve as a practical guide for child welfare directors who are looking to expand or sustain services for the children and families that they serve. This paper focuses on ways to partner with Medicaid to leverage opportunities to provide high quality services for children in child welfare who have behavioral health needs. It also includes information that will provide a foundational understanding of the behavioral health needs of children involved with the child welfare system, with an emphasis on describing child behavior through the lens of child development, adaptive functioning, and trauma; the services that can effectively address those behavioral and trauma related responses that can disrupt a child's skills and abilities; and, examples from states and counties who are providing these services and supports

TRIAD - Preliminary design of an operational earth resources survey system Final report

Design of operational earth resources survey syste

Root to Kellerer

We revisit Kellerer's Theorem, that is, we show that for a family of real probability distributions $(\mu_t)_{t\in [0,1]}$ which increases in convex order there exists a Markov martingale $(S_t)_{t\in[0,1]}$ s.t.\ $S_t\sim \mu_t$. To establish the result, we observe that the set of martingale measures with given marginals carries a natural compact Polish topology. Based on a particular property of the martingale coupling associated to Root's embedding this allows for a relatively concise proof of Kellerer's theorem. We emphasize that many of our arguments are borrowed from Kellerer \cite{Ke72}, Lowther \cite{Lo07}, and Hirsch-Roynette-Profeta-Yor \cite{HiPr11,HiRo12}.Comment: 8 pages, 1 figur

Kinetic and Spectroscopic Characterization of the H178A Methionyl Aminopeptidase from \u3cem\u3eEscherichia coli\u3c/em\u3e

To gain insight into the role of the strictly conserved histidine residue, H178, in the reaction mechanism of the methionyl aminopeptidase from Escherichia coli (EcMetAP-I), the H178A mutant enzyme was prepared. Metal-reconstituted H178A binds only one equivalent of Co(II) or Fe(II) tightly with affinities that are identical to the WT enzyme based on kinetic and isothermal titration calorimetry (ITC) data. Electronic absorption spectra of Co(II)-loaded H178A EcMetAP-I indicate that the active site divalent metal ion is pentacoordinate, identical to the WT enzyme. These data indicate that the metal binding site has not been affected by altering H178. The effect of altering H178 on activity is, in general, due to a decrease in kcat. The kcat value for Co(II)-loaded H178A decreased 70-fold toward MGMM and 290-fold toward MP-p-NA compared to the WT enzyme, while kcat decreased 50-fold toward MGMM for the Fe(II)-loaded H178A enzyme and 140-fold toward MP-p-NA. The Km values for MGMM remained unaffected, while those for MP-p-NA increased approximately 2-fold for Co(II)- and Fe(II)-loaded H178A. The kcat/Km values for both Co(II)- and Fe(II)-loaded H178A toward both substrates ranged from ∼50- to 580-fold reduction. The pH dependence of log Km, log kcat, and log(kcat/Km) of both WT and H178A EcMetAP-I were also obtained and are identical, within error, for H178A and WT EcMetAP-I. Therefore, H178A is catalytically important but is not required for catalysis. Assignment of one of the observed pKa values at 8.1 for WT EcMetAP-I was obtained from plots of molar absorptivity at λmax(640) vs pH for both WT and H178A EcMetAP-I. Apparent pKa values of 8.1 and 7.6 were obtained for WT and H178A EcMetAP-I, respectively, and were assigned to the deprotonation of a metal-bound water molecule. The data reported herein provide support for the key elements of the previously proposed mechanism and suggest that a similar mechanism can apply to the enzyme with a single metal in the active site

Mapping Nitrogen Fixing Shrubs in Dry Unimproved Tussock Grassland

Global Positioning System (GPS) was used to both map the positions of individual nitrogen-fixing shrub plants and record individual plant height and breadth dimensions, within a small catchment of dry sub-humid unimproved short tussock grassland. The distributions of different species of shrubs varied with different landscape units within the catchment. The information will provide the base data for a first approximation of the role of the shrubs in the nitrogen balance of the ecosystem, which is pivotal to the sustainability of pastoral farming in the tussock grasslands

Male Antarctic fur seals: neglected food competitors of bioindicator species in the context of an increasing Antarctic krill fishery.

The fishery for Antarctic krill is currently managed using a precautionary, ecosystem-based approach to limiting catch, with performance indices from a long-term monitoring program focused on several krill-dependent predators that are used to track ecosystem health. Concerns over increased fishing in concentrated areas and ongoing efforts to establish a Marine Protected Area along the Peninsula, a key fishing region, is driving the development of an adaptive management system for the fishery. The cumulative effects of fishing effort and interactions among krill-dependent predators and their performance is at present neglected in the CCAMLR Ecosystem Monitoring Program. However, we show considerable overlap between male Antarctic fur seals and the krill fishery in a complex mosaic, suggesting potential for cumulative impacts on other krill dependent predators. A holistic view is required as part of future efforts to manage the krill fishery that incorporates various sources of potential impacts on the performance of bioindicator species, including the fishery and its interactions with various krill dependent predators. © 2020, The Author(s)

All at sea: When duty meets austerity in scheduling monuments in english waters

The current policy and legal framework surrounding the scheduling of submerged monuments in English waters, its application and the implications for the conservation of underwater cultural heritage arising is reviewed. Historic England (HE's) new policy being seemingly based primarily upon the perceived implications for its resources. The resulting dichotomy of policy between DCMS and its statutory advisers is at best confusing to both the marine archeological community and the public, at worst it may be ultra vires. At times of unprecedented public funding austerity statutory agencies such as HE need to build support amongst their public constituencies. Formulating such an approach is potentially alienating and does not seen well designed to achieve this. The 1979 Act also appears to offer a versatile instrument for managing underwater sites. Indeed the Act may fit HE's public agenda better than the 1973 Act, delivering the public access that HE desires, without he resource implications generated pursuant to the granting of licenses for visiting under the 1973 Act