18,363 research outputs found
An evolution strategy to estimate emission source distributions on a regional scale from atmospheric observations
International audienceIn this paper we present an Evolution Strategy (ES) approach towards the estimation of the location and strength of surface emissions of trace gases based on atmospheric concentration measurements and back-trajectory analyses. The details of the ES developed are outlined. The ES is tested using artificial emission maps at different grid resolutions and the results compared to those obtained on the same problems using Singular Value Decomposition (SVD). In almost all cases, the ES improves on SVD at equivalent resolutions. In addition, a number of insights, which the ES approach brings to the problem of source location and emission strength, are discussed, particularly the limitations on the use of measurement and meteorological data in the determination of emission source distribution
Continuous monitoring of extracellular glucose concentrations in the striatum of freely moving rats with an implanted glucose biosensor
We have used a glucose oxidase-based sensor implanted in the striatum of freely moving rats to determine the concentration of extracellular glucose in two distinct ways. With a modification of the zero net flux method, in which different concentrations of glucose are infused through a dialysis probe glued to the biosensor, we calculated the concentration at which there was no change in glucose current by regression analysis; this gave a concentration of 0.351 ± 0.016 mM. Calculating the concentration from the basal current and the in vitro calibration of the biosensor was not significantly different from this. The basal extracellular glucose concentration determined by either method remained constant over a period of several days. Infusion of 50 µM veratridine through the adjacent dialysis probe caused a steep decrease in glucose current as soon as the drug reached the brain in contrast to the delayed fall (7.5 min) seen with microdialysis in previous experiments from this laboratory. These results demonstrate that this biosensor provides a direct, real-time measure of the extracellular concentration of glucose
Compensation of Strong Thermal Lensing in High Optical Power Cavities
In an experiment to simulate the conditions in high optical power advanced
gravitational wave detectors such as Advanced LIGO, we show that strong thermal
lenses form in accordance with predictions and that they can be compensated
using an intra-cavity compensation plate heated on its cylindrical surface. We
show that high finesse ~1400 can be achieved in cavities with internal
compensation plates, and that the cavity mode structure can be maintained by
thermal compensation. It is also shown that the measurements allow a direct
measurement of substrate optical absorption in the test mass and the
compensation plate.Comment: 8 page
Chiral molecules split light: Reflection and refraction in a chiral liquid
A light beam changes direction as it enters a liquid at an angle from another
medium, such as air. Should the liquid contain molecules that lack mirror
symmetry, then it has been predicted by Fresnel that the light beam will not
only change direction, but will actually split into two separate beams with a
small difference in the respective angles of refraction. Here we report the
observation of this phenomenon. We also demonstrate that the angle of
reflection does not equal the angle of incidence in a chiral medium. Unlike
conventional optical rotation, which depends on the path-length through the
sample, the reported reflection and refraction phenomena arise within a few
wavelengths at the interface and thereby suggest a new approach to polarimetry
that can be used in microfluidic volumes
Natural organic matter in sedimentary basins and its relation to arsenic in anoxic ground water: the example of West Bengal and its worldwide implications
In order to investigate the mechanism of As release to anoxic ground water in alluvial aquifers, the authors sampled ground waters from 3 piezometer nests, 79 shallow (80 m) wells, in an area 750 m by 450 m, just north of Barasat, near Kolkata (Calcutta), in southern West Bengal. High concentrations of As (200-1180 mug L-1) are accompanied by high concentrations of Fe (3-13.7 mgL(-1)) and PO4 (1-6.5 mg L-1). Ground water that is rich in Mn (1-5.3 mg L-1) contains <50 mug L-1 of As. The composition of shallow ground water varies at the 100-m scale laterally and the metre-scale vertically, with vertical gradients in As concentration reaching 200 mug L-1 m(-1). The As is supplied by reductive dissolution of FeOOH and release of the sorbed As to solution. The process is driven by natural organic matter in peaty strata both within the aquifer sands and in the overlying confining unit. In well waters, thermotolerant coliforms, a proxy for faecal contamination, are not present in high numbers (<10 cfu/100 ml in 85% of wells) showing that faecally-derived organic matter does not enter the aquifer, does not drive reduction of FeOOH, and so does not release As to ground water.Arsenic concentrations are high (much greater than50 mug L-1) where reduction of FeOOH is complete and its entire load of sorbed As is released to solution, at which point the aquifer sediments become grey in colour as FeOOH vanishes. Where reduction is incomplete, the sediments are brown in colour and resorption of As to residual FeOOH keeps As concentrations below 10 mug L-1 in the presence of dissolved Fe. Sorbed As released by reduction of Mn oxides does not increase As in ground water because the As resorbs to FeOOH. High concentrations of As are common in alluvial aquifers of the Bengal Basin arise because Himalayan erosion supplies immature sediments, with low surface-loadings of FeOOH on mineral grains, to a depositional environment that is rich in organic mater so that complete reduction of FeOOH is common. (C) 2004 Published by Elsevier Ltd
Huddle test measurement of a near Johnson noise limited geophone
In this paper, the sensor noise of two geophone configurations (L-22D and L-4C geophones from Sercel with custom built amplifiers) was measured by performing two huddle tests. It is shown that the accuracy of the results can be significantly improved by performing the huddle test in a seismically quiet environment and by using a large number of reference sensors to remove the seismic foreground signal from the data. Using these two techniques, the measured sensor noise of the two geophone configurations matched the calculated predictions remarkably well in the bandwidth of interest (0.01 Hz–100 Hz). Low noise operational amplifiers OPA188 were utilized to amplify the L-4C geophone to give a sensor that was characterized to be near Johnson noise limited in the bandwidth of interest with a noise value of 10−11 m/Hz⎯⎯⎯⎯⎯√10−11 m/Hz at 1 Hz
Control of the Oxygen Dependence of an Implantable Polymer/Enzyme Composite Biosensor for Glutamate
Biosensors for glutamate (Glu) were fabricated from Teflon-coated Pt wire (cylinders and disks), modified with the enzyme glutamate oxidase (GluOx) and electrosynthesized polymer PPD, poly(o-phenylenediamine). The polymer/enzyme layer was deposited in two configurations:  enzyme before polymer (GluOx/PPD) and enzyme after polymer (PPD/GluOx). These four biosensor designs were characterized in terms of response time, limit of detection, Michaelis−Menten parameters for Glu (Jmax and KM(Glu)), sensitivity to Glu in the linear response region, and dependence on oxygen concentration, KM(O2). Analysis showed that the two polymer/enzyme configurations behaved similarly on both cylinders and disks. Although the two geometries showed different behaviors, these differences could be explained in terms of higher enzyme loading density on the disks; in many analyses, the four designs behaved like a single population with a range of GluOx loading. Enzyme loading was the key to controlling the KM(O2) values of these first generation biosensors. The counterintuitive, and beneficial, behavior that biosensors with higher GluOx loading displayed a lower oxygen dependence was explained in terms of the effects of enzyme loading on the affinity of GluOx for its anionic substrate. Some differences between the properties of surface immobilized GluOx and glucose oxidase are highlighted
Interactions of asbestos-activated macrophages with an experimental fibrosarcoma
Supernatants from in vivo asbestos-activated macrophages failed to show any cytostatic activity against a syngeneic fibrosarcoma cell line in vitro. UICC chrysotile-induced peritoneal exudate cells also failed to demonstrate any growth inhibitory effect on the same cells in Winn assays of tumor growth. Mixing UICC crocidolite with inoculated tumor cells resulted in a dose-dependent inhibition of tumor growth; this could, however, be explained by a direct cytostatic effect on the tumor cells of high doses of crocidolite, which was observed in vitro
RECENT FLUID PROCESSES IN THE KAAPVAAL CRATON, SOUTH AFRICA: COUPLED OXYGEN ISOTOPE AND TRACE ELEMENT DISEQUILIBRIUM IN POLYMICT PERIDOTITES
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