Expectations and U.K. firms' employment and production plans: Microeconometric analysis of the CBI's business survey.

This thesis uses the opinions of U.K. business managers about past and future trends in key economic variables to test a number of basic economic theories of firm behaviour: the decision to hire labour, to expand production, and to change prices. Individual qualitative responses from the Confederation of British Industry's quarterly Industrial Trends Survey from September 1982 to January 1984 are used to determine if firms act on expectations in the manner predicted by economic theory, that is, firms should adjust their behaviour in accordance to expected changes in external business conditions. Access to individual firms' responses over consecutive surveys results in data on both plans and expectations formulated in one period, and the realizations of those plans and expectations in the next period. The qualitative responses are used in ordered probit and conditional log-linear models to determine how expectations of external factors shape a firm's plan, as well as to determine why a firm did not follow through on its plan. Overall, the role of expectations in economic decision-making are confirmed. Firms plan to hire and to raise production if demand conditions are expected to improve, and vice versa. Firms plan to raise prices if cost conditions are expected to worsen, and vice versa. The fulfillment of plans is contingent on "errors" in forecasting external conditions. Firms adjust their plans in the manner that economic theory predicts if conditions differ from what was originally predicted. These conclusions applied whether the data was all firms in the sample (roughly 9000) or a special sub-sample of firms (roughly 550) which responded to all six quarterly surveys

Pressure training in sport : Factors to enhance design and delivery of applied interventions

This thesis examined how sport psychologists can design and deliver pressure training (PT) to maximise PT’s impact on performance in sport. Adopting a pragmatic approach to research, four studies were conducted to provide practitioners with guidance for conducting PT. The first study was a meta-analysis of previous PT interventions. PT had a moderate positive effect on performance under pressure when compared to training without pressure. Building on Stoker et al.’s (2016) framework for creating pressure, the second study identified properties of pressure manipulations that international-level athletes and sport psychologists had found to be effective. This study also explored the specific benefits of PT that lead to improved performance. In the third study, athletes and sport psychologists also described effective delivery of PT. Key findings included processes such as collaboration and integration of PT into training sessions, and these processes may counter risks that PT could pose to athletes’ wellbeing. The fourth study applied the previous findings to a PT intervention with a professional women’s basketball team. Results further extended knowledge on creating pressure and delivering PT. Specifically, pressure may be created more effectively through negative, rather than positive, consequences that have meaningful implications for athletes. This study also highlighted that fully integrating PT into training can include coaches reinforcing pressure manipulations and supporting performance under pressure. Additional applied implications of this thesis include PT’s potential to complement mental skills training and the need to distinguish PT from training that simulates other aspects of competition. Future research can investigate the training environments and characteristics of individuals that are conducive to effective PT. More knowledge on creating pressure is especially needed for team sports because of individual differences within a team. Studies can also test the properties of pressure manipulations that were explored qualitatively in this thesis

Measles Vaccination in HIV-Infected Children: Systematic Review and Meta-Analysis of Safety and Immunogenicity

Background. Measles control may be more challenging in regions with a high prevalence of HIV infection. HIV-infected children are likely to derive particular benefit from measles vaccines because of an increased risk of severe illness. However, HIV infection can impair vaccine effectiveness and may increase the risk of serious adverse events after receipt of live vaccines. We conducted a systematic review to assess the safety and immunogenicity of measles vaccine in HIV-infected children. Methods. The authors searched 8 databases through 12 February 2009 and reference lists. Study selection and data extraction were conducted in duplicate. Meta-analysis was conducted when appropriate. Results. Thirty-nine studies published from 1987 through 2008 were included. In 19 studies with information about measles vaccine safety, more than half reported no serious adverse events. Among HIV-infected children, 59% (95% confidence intervals [CI], 46-71%) were seropositive after receiving standard-titer measles vaccine at 6 months (1 study), comparable to the proportion of seropositive HIV-infected children vaccinated at 9 (8 studies) and 12 months (10 studies). Among HIV-exposed but uninfected and HIV-unexposed children, the proportion of seropositive children increased with increasing age at vaccination. Fewer HIV-infected children were protected after vaccination at 12 months than HIV-exposed but uninfected children (relative risk, 0.61; 95% CI, .50-.73). Conclusions. Measles vaccines appear to be safe in HIV-infected children, but the evidence is limited. When the burden of measles is high, measles vaccination at 6 months of age is likely to benefit children of HIV-infected women, regardless of the child's HIV infection statu

Recent Decisions

Comments on recent decisions by Joseph N. Low, Robert A. Stewart, William M. Dickson, Edward G. Coleman, James F. O\u27Rieley, James J. Haranzo, Robert C. Enburg, E. Milton Farley III, Jerome A. Kolenda, Bernard James McGraw, Joseph C. Spalding, R. Emmett Fitzgerald, Joseph T. Helling, John F. Laughlin, Andrew V. Giorgi, and Jack Fena

Story understanding in Genesis : exploring automatic plot construction through commonsense reasoning

Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2011.Cataloged from PDF version of thesis.Includes bibliographical references (p. 72).Whether through anecdotes, folklore, or formal history, humans learn the lessons and expectations of life from stories. If we are to build intelligent programs that learn as humans do, such programs must understand stories as well. Casting narrative text in an information-rich representation affords Al research platforms, such as the Genesis system, the capacity to understand the events of stories individually. To understand a story, however, a program must understand not just events, but also how events cause and motivate one another. In order to understand the relationships between these events, stories must be saturated with implicit details, connecting given events into coherent plot arcs. In my research, my first step was to analyze a range of story summaries in detail. Using nearly 50 rules, applicable to brief summaries of stories taken from international politics, group dynamics, and basic human emotion, I demonstrate how a rendition of Frank Herbert's Dune can be automatically understood so as to produce an interconnected story network of over one hundred events. My second step was to explore the nuances of rule construction, finding which rules are needed to create story networks reflective of proper implicit understanding and how we, as architects, must shape those rules to be understood. In particular, I develop a method that constructs new rules using the rules already embedded in stories, a representation of higher-order thinking that enables us to speak of our ideas as objects.by Harold William Capen Low, IV.M.Eng

Electronic Structures of Nitridomanganese(V) Complexes

The single-crystal polarized absorption and circular dichroism spectra of the nitridomanganese(V) complexes (salen)Mn⋮N (1), (1S,2S-(−)-saldpen)Mn⋮N (2), and (1R,2R-(+)-saldpen)Mn⋮N (3) have been measured [salen = N,N‘-ethylenebis(salicylideneaminato) dianion, 1S,2S-(−)-saldpen = N,N‘-(1S,2S-(−)-diphenyl)ethylenebis(salicylideneaminato) dianion, and 1R,2R-(+)-saldpen = N,N‘-(1R,2R-(+)-diphenyl)ethylenebis(salicylideneaminato) dianion]. As revealed by X-ray crystal structure analyses, these molecules have a distorted square-pyramidal geometry with a short Mn⋮N bond distance (1.52(3) Å for 2). The Cs compounds have a low-spin^ 1A‘[a‘(x^2 − y^2)]^2 ground state. The lowest absorption system (∼600 nm) consists of two components that are separated by approximately 4000 cm^(-1); these are assigned to ^1A‘ → ^1A‘[a‘(x^2 − y^2)a‘(yz)] (14 900 cm^(-1)) and ^1A‘ → ^1A‘‘[a‘(x^2 − y^2)a‘‘(xz)] (18 900 cm^(-1)) transitions

Functional plasticity of antibacterial EndoU toxins.

Bacteria use several different secretion systems to deliver toxic EndoU ribonucleases into neighboring cells. Here, we present the first structure of a prokaryotic EndoU toxin in complex with its cognate immunity protein. The contact-dependent growth inhibition toxin CdiA-CTSTECO31 from Escherichia coli STEC_O31 adopts the eukaryotic EndoU fold and shares greatest structural homology with the nuclease domain of coronavirus Nsp15. The toxin contains a canonical His-His-Lys catalytic triad in the same arrangement as eukaryotic EndoU domains, but lacks the uridylate-specific ribonuclease activity that characterizes the superfamily. Comparative sequence analysis indicates that bacterial EndoU domains segregate into at least three major clades based on structural variations in the N-terminal subdomain. Representative EndoU nucleases from clades I and II degrade tRNA molecules with little specificity. In contrast, CdiA-CTSTECO31 and other clade III toxins are specific anticodon nucleases that cleave tRNAGlu between nucleotides C37 and m2 A38. These findings suggest that the EndoU fold is a versatile scaffold for the evolution of novel substrate specificities. Such functional plasticity may account for the widespread use of EndoU effectors by diverse inter-bacterial toxin delivery systems

An iPSC-derived vascular model of Marfan syndrome identifies key mediators of smooth muscle cell death.

Marfan syndrome (MFS) is a heritable connective tissue disorder caused by mutations in FBN1, which encodes the extracellular matrix protein fibrillin-1. To investigate the pathogenesis of aortic aneurysms in MFS, we generated a vascular model derived from human induced pluripotent stem cells (MFS-hiPSCs). Our MFS-hiPSC-derived smooth muscle cells (SMCs) recapitulated the pathology seen in Marfan aortas, including defects in fibrillin-1 accumulation, extracellular matrix degradation, transforming growth factor-β (TGF-β) signaling, contraction and apoptosis; abnormalities were corrected by CRISPR-based editing of the FBN1 mutation. TGF-β inhibition rescued abnormalities in fibrillin-1 accumulation and matrix metalloproteinase expression. However, only the noncanonical p38 pathway regulated SMC apoptosis, a pathological mechanism also governed by Krüppel-like factor 4 (KLF4). This model has enabled us to dissect the molecular mechanisms of MFS, identify novel targets for treatment (such as p38 and KLF4) and provided an innovative human platform for the testing of new drugs.This work was supported by Evelyn Trust, the NIHR Cambridge Biomedical Research Centre and the British Heart Foundation (FS/13/29/30024, RM/l3/3/30159, FS/11/77/29327).This is the author accepted manuscript. The final version is available from Nature Publishing Group via https://doi.org/10.1038/ng.372