15,563 research outputs found
Realizable Hamiltonians for Universal Adiabatic Quantum Computers
It has been established that local lattice spin Hamiltonians can be used for
universal adiabatic quantum computation. However, the 2-local model
Hamiltonians used in these proofs are general and hence do not limit the types
of interactions required between spins. To address this concern, the present
paper provides two simple model Hamiltonians that are of practical interest to
experimentalists working towards the realization of a universal adiabatic
quantum computer. The model Hamiltonians presented are the simplest known
QMA-complete 2-local Hamiltonians. The 2-local Ising model with 1-local
transverse field which has been realized using an array of technologies, is
perhaps the simplest quantum spin model but is unlikely to be universal for
adiabatic quantum computation. We demonstrate that this model can be rendered
universal and QMA-complete by adding a tunable 2-local transverse XX coupling.
We also show the universality and QMA-completeness of spin models with only
1-local Z and X fields and 2-local ZX interactions.Comment: Paper revised and extended to improve clarity; to appear in Physical
Review
Charged spin 1/2 particle in an arbitrary magnetic field in two spatial dimensions: a supersymmetric quantum mechanical system
It is shown that the 2 X 2 matrix Hamiltonian describing the dynamics of a
charged spin 1/2 particle with g-factor 2 moving in an arbitrary, spatially
dependent, magnetic field in two spatial dimensions can be written as the
anticommuator of a nilpotent operator and its hermitian conjugate.
Consequently, the Hamiltonians for the two different spin projections form
partners of a supersymmetric quantum mechanical system. The resulting
supersymmetry algebra can then be exploited to explicitly construct the exact
zero energy ground state wavefunction for the system. Modulo this ground state,
the remainder of the eigenstates and eigenvalues of the two partner
Hamiltonians form positive energy degenerate pairs. We also construct the
spatially asymptotic form of the magnetic field which produces a finite
magnetic flux and associated zero energy normalizable ground state
wavefunction.Comment: 10 pages, LaTe
Why P/OF should look for evidences of over-dense structures in solar flare hard X-ray sources
White-light and hard X-ray (HXR) observations of two white-light flares (WLFs) show that if the radiative losses in the optical continuum are powered by fast electrons directly heating the WLF source, then the column density constraints imposed by the finite range of the electrons requires that the WLF consist of an over-dense region in the chromosphere, with density exceeding 10 to the 14th power/cu cm. Thus, we recommend that P/OF search for evidences of over-dense structures in HXR images obtained simultaneously with optical observations of flares
Net energy analysis of solar and conventional domestic hot water systems in Melbourne, Australia
It is commonly assumed that solar hot water systems save energy and reduce greenhouse gas emissions. Very rarely has the life-cycle energy requirements of solar hot water systems been analysed, including their embodied energy. The extent to which solar hot water systems save energy compared to conventional systems in Melbourne, Australia, is shown through a comparative net energy analysis. The solar systems provided a net energy saving compared to the conventional systems after 0.5 to 2 years, for electricity and gas systems respectively.<br /
The Bravyi-Kitaev transformation for quantum computation of electronic structure
Quantum simulation is an important application of future quantum computers
with applications in quantum chemistry, condensed matter, and beyond. Quantum
simulation of fermionic systems presents a specific challenge. The
Jordan-Wigner transformation allows for representation of a fermionic operator
by O(n) qubit operations. Here we develop an alternative method of simulating
fermions with qubits, first proposed by Bravyi and Kitaev [S. B. Bravyi, A.Yu.
Kitaev, Annals of Physics 298, 210-226 (2002)], that reduces the simulation
cost to O(log n) qubit operations for one fermionic operation. We apply this
new Bravyi-Kitaev transformation to the task of simulating quantum chemical
Hamiltonians, and give a detailed example for the simplest possible case of
molecular hydrogen in a minimal basis. We show that the quantum circuit for
simulating a single Trotter time-step of the Bravyi-Kitaev derived Hamiltonian
for H2 requires fewer gate applications than the equivalent circuit derived
from the Jordan-Wigner transformation. Since the scaling of the Bravyi-Kitaev
method is asymptotically better than the Jordan-Wigner method, this result for
molecular hydrogen in a minimal basis demonstrates the superior efficiency of
the Bravyi-Kitaev method for all quantum computations of electronic structure
Integrated scalable cyto-technology for recombinant protein bioprocessing
Biological knowledge of infectious diseases and other diseases for which vaccines may provide therapeutic benefits, such as cancer, is growing at an accelerated pace. The implications of this knowledge are improved stratification of diseases, possibilities for personalized treatments, and explicit understanding of protective immune responses to be elicited by vaccines. With this knowledge, it is becoming increasingly feasible to engineer vaccines for specific responses rather than relying on empirical development. Despite this potential, the challenge of routine, low-cost manufacturing of vaccines creates a barrier to transforming health care in both high- and low-resource countries. Vaccines today do not benefit from well-defined, platform-like processes for manufacturing, and concepts such as continuous bioprocessing remain largely within the realm of biopharmaceutical products. The InSCyT platform is an advanced prototype manufacturing system that provides integrated and automated production and purification of multiple protein therapeutics. The system allows end-to-end manufacturing of 100\u27s to 10,000\u27s of doses of recombinant protein drugs in days. It uses a state-of-the-art approach to process design and implementation that takes advantage of a fast-growing, tractable microbial host (Pichia pastoris) and continuous processing for automated, hands-free purification through simple 2- or 3-stage chromatographic processes. The platform design is highly modular, allowing facile process development and process deployment for multiple products. This feature emerges from the predictable behavior of the fermentation and cell culture fluids, and rapid cloning of new molecules, that together facilitate fast development of entirely new processes in weeks. To date, this system has been used to reproducibly manufacture high-quality human growth hormone (hGH), granulocyte-colony stimulating factor (G-CSF), and interferon-α2b (IFN-α2b) in an integrated, automated manner. The speed of production using the InSCyT prototype allows volumetric productivities that compare favorably to those for mammalian-based production. This talk will outline the design and capabilities of the InSCyT system, demonstrate the quality of biologic drugs made to date on the system, and outline opportunities for advancing the platform to provide new capabilities in manufacturing recombinant proteins for use in vaccines. As part of a Gates Foundation-funded Grand Challenge called ULTRA, we have begun to assess the feasibility of manufacturing millions of doses of a trivalent recombinant rotavirus vaccine annually on a small-scale production system like InSCyT. Integrated bioprocessing enabled by systems such as these could offer potential advantages for routine production in local regions with minimal infrastructure, and for democratization of manufacturing capacity for new vaccine concepts and personalized treatments in cancer
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