2 research outputs found
VALEUR PREDICTIVE POSITIVE DU TEST DE RESISTANCE ET DE LA PONCTION LOMBAIRE DEPLETIVE DANS LâHYDROCEPHALIE CHRONIQUE DE LâADULTE: SUR UNE SERIE DE 46 CAS
Introduction : LâhydrocĂ©phalie chronique de lâadulte (HCA) a une expression clinique reposant sur une triade dâAdams Hakim, associant des perturbations locomotrices, des troubles intellectuels et une incontinence urinaire. Devant un tableau clinique Ă©vocateur, les principaux arguments restent lâimagerie et la rĂ©versibilitĂ© des signes aprĂšs la rĂ©alisation de ponctions lombaires dĂ©plĂ©tives. MatĂ©riels et MĂ©thodes : Ă©tude rĂ©trospective portant sur 46 patients suivis pour une hydrocĂ©phalie chronique de lâadulte entre Janvier 1997 Ă DĂ©cembre 2013 dans notre service en insistant sur lâintĂ©rĂȘt du test de rĂ©sistance Ă lâĂ©coulement de LCR. RĂ©sultats : il sâagissait de 25 hommes et 21 femmes, lâĂąge moyen Ă©tait de 62 ans. La durĂ©e moyenne dâĂ©volution des symptĂŽmes Ă©tait de 18 mois.La triade dâAdams Hakim Ă©tait complĂšte chez 19/46 (41.3%), les troubles moteurs au 1er plan chez 12/46 (26%), suivi des troubles sphinctĂ©riens chez 8/46 (17.3%), et les dĂ©mences chez 7/46 (15.2%). Une ponction lombaire soustractive dâau moins 30cc a Ă©tĂ© rĂ©alisĂ©e chez tous les patients et le test de rĂ©sistance chez 33 patients (71.7%). La ponction lombaire Ă©tait positive chez 39 patients, dont 28 se sont amĂ©liorĂ©s aprĂšs dĂ©rivation. Le test de rĂ©sistance Ă lâĂ©coulement de LCR Ă©tait positif chez 24 patients, dont 19 se sont amĂ©liorĂ©s aprĂšs dĂ©rivation. La valeur prĂ©dictive positive des deux tests diagnostic est de 79.1% pour le test de rĂ©sistance et de 72% pour la ponction lombaire. Conclusion : Le test de rĂ©sistance Ă lâĂ©coulement de LCR, bien que rarement utilisĂ©, a pourtant toute sa place parmi les outils diagnostiques
Variation in postoperative outcomes of patients with intracranial tumors: insights from a prospective international cohort study during the COVID-19 pandemic
Background:
This study assessed the international variation in surgical neuro-oncology practice and 30-day outcomes of patients who had surgery for an intracranial tumor during the COVID-19 pandemic.
Methods:
We prospectively included adults aged â„18 years who underwent surgery for a malignant or benign intracranial tumor across 55 international hospitals from 26 countries. Each participating hospital recorded cases for 3 consecutive months from the start of the pandemic. We categorized patientsâ location by World Bank income groups (high [HIC], upper-middle [UMIC], and low- and lower-middle [LLMIC]). Main outcomes were a change from routine management, SARS-CoV-2 infection, and 30-day mortality. We used a Bayesian multilevel logistic regression stratified by hospitals and adjusted for key confounders to estimate the association between income groups and mortality.
Results:
Among 1016 patients, the number of patients in each income group was 765 (75.3%) in HIC, 142 (14.0%) in UMIC, and 109 (10.7%) in LLMIC. The management of 200 (19.8%) patients changed from usual care, most commonly delayed surgery. Within 30 days after surgery, 14 (1.4%) patients had a COVID-19 diagnosis and 39 (3.8%) patients died. In the multivariable model, LLMIC was associated with increased mortality (odds ratio 2.83, 95% credible interval 1.37â5.74) compared to HIC.
Conclusions:
The first wave of the pandemic had a significant impact on surgical decision-making. While the incidence of SARS-CoV-2 infection within 30 days after surgery was low, there was a disparity in mortality between countries and this warrants further examination to identify any modifiable factors