Modelling of basic creep effect on concrete damage at a mesoscale level

In its service-life concrete is loaded and delayed strains appear due to creep phenomenon. Some theories suggest that micro-cracks nucleate and grow up when concrete is submitted to a high sustained loading, which contribute to make the concrete weaker. Thus, it is important to understand the interaction between the viscoelastic deformation and damage in order to design reliable civil engineering structures. Several creep-damage theoretical models have been proposed in the literature. However most of these models are based on empirical relations applied at the macroscopic scale. Coupling between creep and damage is mostly realised by adding some parameters to take into account the microstructure effects. In the author opinion, the microstructure effects can be modelled by taking into account the effective interactions between the concrete matrix and the inclusions. In this paper, a viscoelastic model is combined with an isotropic damage model. The material volume is modelled by a Digital Concrete model which takes into account the "real" aggregate size distribution of concrete. The results show that stresses are induced by strain incompatibilities between the matrix and aggregates at mesoscale under creep and lead to cracking

Pyrrolidine dithiocarbamate administered during ex-vivo lung perfusion promotes rehabilitation of injured donor rat lungs obtained after prolonged warm ischemia.

Damaged lung grafts obtained after circulatory death (DCD lungs) and warm ischemia may be at high risk of reperfusion injury after transplantation. Such lungs could be pharmacologically reconditioned using ex-vivo lung perfusion (EVLP). Since acute inflammation related to the activation of nuclear factor kappaB (NF-κB) is instrumental in lung reperfusion injury, we hypothesized that DCD lungs might be treated during EVLP by pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-κB. Rat lungs exposed to 1h warm ischemia and 2 h cold ischemia were subjected to EVLP during 4h, in absence (CTRL group, N = 6) or in presence of PDTC (2.5g/L, PDTC group, N = 6). Static pulmonary compliance (SPC), peak airway pressure (PAWP), pulmonary vascular resistance (PVR), and oxygenation capacity were determined during EVLP. After EVLP, we measured the weight gain of the heart-lung block (edema), and the concentration of LDH (cell damage), proteins (permeability edema) and of the cytokines IL-6, TNF-α and CINC-1 in bronchoalveolar lavage (BAL), and we evaluated NF-κB activation by the degree of phosphorylation and degradation of its inhibitor IκBα in lung tissue. In CTRL, we found significant NF-κB activation, lung edema, and a massive release of LDH, proteins and cytokines. SPC significantly decreased, PAWP and PVR increased, while oxygenation tended to decrease. Treatment with PDTC during EVLP inhibited NF-κB activation, did not influence LDH release, but markedly reduced lung edema and protein concentration in BAL, suppressed TNFα and IL-6 release, and abrogated the changes in SPC, PAWP and PVR, with unchanged oxygenation. In conclusion, suppression of innate immune activation during EVLP using the NF-κB inhibitor PDTC promotes significant improvement of damaged rat DCD lungs. Future studies will determine if such rehabilitated lungs are suitable for in vivo transplantation

Dynamic behavior of a brushless inrunner motor

In this article, a model of a rotor with an asymmetric disk is presented in order to represent Campbell's diagrams and instability maps as a function of the rotations of the support which can significantly change the dynamic behavior of the rotor. Critical rotating speeds can also lead to unacceptable levels of vibration. Indeed, the critical speeds are a function of the dynamic rigidity of the rotating systems and the presence of the gyroscopic forces creates a dependence between the rotating speed of rotation and the natural frequencies to such structures (the CAMPBELL diagrams): this implies that the correct determination of the critical speeds is one of the essential elements when sizing such dynamic systems

Filtration of solution containing heavy metals and dyes by means of ultrafiltration membranes deposited on support made of Moroccan clay

International audienc

Hydrodynamique dans les milieux gaz/liquide non-newtoniens, agités mécaniquement, étude de l'hélice à profil mince [HPM] et de la turbine à disque de Rushton

The power consumption is measured for non-newtonian gas-liquid systems. The useful zone situated beyond the flooding point was defined by using the power caracteristics plot and hydrodynamic observations. Correlations were established in dimensional or adimensional form, to estimate the stirrer speed at the flooding point, and the power consumption in the working zone. Those correlations established in a large scale of rheological behaviour, for two kind of impellers in different geometrical ratios and for two tanks for scaling up, are used to compare an axial impeller (the thinny profile propeller) to a radial one (the Rushton's disc turbine)

Lymphome malin non hodgkinien primitif bilatéral du sein: à propos d’un cas

Les lymphomes malins non-hodgkiniens (LMNH) primitifs du sein sont des tumeurs rares. Leur symptomatologie clinique est polymorphe. L'imagerie médicale est non-spécifique. Le diagnostic peut être évoqué à l'examen cytologique, sa confirmation est toujours histologique. Il s'agit essentiellement de lymphomes de type B, ceux de type NK/T restant rares. Les plus fréquents sont les lymphomes diffus à grandes cellules présentant la particularité de donner des rechutes sous forme d'extension au système nerveux central. Nous rapportons un cas de LMNH primitif bilatéral du sein chez une patiente âgée de 33 ans, révélé par deux nodules mammaires bilatéraux. La mammographie et l'examen extemporané ont évoqué une tumeur phyllode. Le diagnostic du LMNH n'a été fait qu'après examen histologique définitif. Sous chimiothérapie, l'évolution était favorable avec un recul de 15 mois