981 research outputs found
A Qualitative Analysis of the Experience of Staff Employed within the Forensic Disability Sector in Victoria, Australia
BACKGROUND:
This paper explores the experience of staff employed within forensic disability across Victoria in an attempt to better understand service needs in this field. The complex needs of individuals with disabilities involved in the criminal justice system or presenting with offence-related behaviours suggest that there is a requirement to improve services directed towards forensic disability.
METHODS:
Four semi-structured group interviews, determined by geographical location, were completed with employees (n = 14) within the Australian Community Support Organisation, with an average of 5 years of forensic disability experience. Data were analysed based on thematic analysis.
RESULTS:
Five themes were revealed. Three pre-existing themes were emphasized that included client complexity; poor responses from external services; and funding, and two novel themes labelled as staff well-being and responses to risk.
CONCLUSIONS:
Recommendations include multiagency collaboration, funding forensic disability services, development of best practice initiatives and advocacy
Reliability, Resiliency, Robustness, and Vulnerability Criteria for Water Resource Systems
Three criteria for evaluating the possible performance of water resource systems are discussed. These measures describe how likely a system is to fail (reliability), how quickly it recovers from failure (resiliency), and how severe the consequences of failure may be (vulnerability). These criteria can be used to assist in the evaluation and selection of alternative design and operating policies for a wide variety of water resource projects. The performance of a water supply reservoir with a variety of operating policies illustrates their use.
When water resource investments are made there is little assurance that the predicted performance will coincide with the actual performance. Robustness is proposed as a measure of the likelihood that the actual cost of a proposed project will not exceed some fraction of the minimum possible cost of a system designed for the actual conditions that occur in the future. The robustness criterion is illustrated by its application to the planning of water supply systems in southwestern Sweden
Evidence-Based Professional Development of Science Teachers in Two Countries
The focus of this collaborative research project of King?s College London, and the Weizmann Institute, Israel. project is on investigating the ways in which teachers can demonstrate accomplished teaching in a specific domain of science and on the teacher learning that is generated through continuing professional development programs (CPD) that lead towards such practice. The interest lies in what processes and inputs are required to help secondary school science teachers develop expertise in a specific aspect of science teaching. `It focuses on the design of the CPD programmes and examines the importance of an evidence-based approach through portfolioconstruction in which professional dialogue pathes the way for teacher learning. The set of papers highlight the need to set professional challenge while tailoring CPD to teachers? needs to create the environment in which teachers can advance and transform their practice. The cross-culture perspective added to the richness of the development and enabled the researchers to examine which aspects were fundamental to the design by considering similarities and differences between the domains
Reliability, resiliency, and vulnerability criteria for water resource system performance evaluation
Three criteria for evaluating the possible performance of water resource systems are discussed. These measures describe how likely a system is to fail (reliability), how quickly it recovers from failure (resiliency), and how severe the consequences of failure may be (vulnerability). These criteria can be used to assist in the evaluation and selection of alternative design and operating policies for a wide variety of water resource projects. The performance of a water supply reservoir with a variety of operating policies illustrates their use
Water Resources Systems Planning and Management: An Introduction to Methods, Models and Applications
This 2005 version has been superseded by the 2017 edition, available in full here: http://hdl.handle.net/1813/48159Throughout history much of the world has witnessed
ever-greater demands for reliable, high-quality and
inexpensive water supplies for domestic consumption,
agriculture and industry. In recent decades there have
also been increasing demands for hydrological regimes
that support healthy and diverse ecosystems, provide for
water-based recreational activities, reduce if not prevent
floods and droughts, and in some cases, provide for the
production of hydropower and ensure water levels adequate
for ship navigation. Water managers are challenged
to meet these multiple and often conflicting demands. At
the same time, public stakeholder interest groups have
shown an increasing desire to take part in the water
resources development and management decision making
process. Added to all these management challenges
are the uncertainties of natural water supplies and
demands due to changes in our climate, changes in
people's standards of living, changes in watershed land
uses and changes in technology. How can managers
develop, or redevelop and restore, and then manage water
resources systems - systems ranging from small watersheds
to those encompassing large river basins and coastal
zones - in a way that meets society's changing objectives
and goals? In other words, how can water resources
systems become more integrated and sustainable
Cortical dynamics of disfluency in adults who stutter
Citation: Sengupta, R., Shah, S., Loucks, T. M. J., Pelczarski, K., Scott Yaruss, J., Gore, K., & Nasir, S. M. (2017). Cortical dynamics of disfluency in adults who stutter. Physiological Reports, 5(9). doi:10.14814/phy2.13194Stuttering is a disorder of speech production whose origins have been traced to the central nervous system. One of the factors that may underlie stuttering is aberrant neural miscommunication within the speech motor network. It is thus argued that disfluency (any interruption in the forward flow of speech) in adults who stutter (AWS) could be associated with anomalous cortical dynamics. Aberrant brain activity has been demonstrated in AWS in the absence of overt disfluency, but recording neural activity during disfluency is more challenging. The paradigm adopted here took an important step that involved overt reading of long and complex speech tokens under continuous EEG recording. Anomalies in cortical dynamics preceding disfluency were assessed by subtracting out neural activity for fluent utterances from their disfluent counterparts. Differences in EEG spectral power involving alpha, beta, and gamma bands, as well as anomalies in phase-coherence involving the gamma band, were observed prior to the production of the disfluent utterances. These findings provide novel evidence for compromised cortical dynamics that directly precede disfluency in AWS. © 2017 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society
A double-edged sword : childrenâs experiences of visiting a parent in prison in Scotland
Prison visits are recognised as an important feature of a humane prison system, providing important benefits for prisoners and their family in maintaining ties (McCarthy & Adams, 2017). Scotland has a history of penal welfarism and a right-based agenda in relation to visits (McCarthy & Adams, 2017); however, there is a lack of research that focuses on visits in the context of Scottish prisons. Equally, there is limited research that considers the perspective of children visiting a parent in custody. This paper explores the experiences of children visiting a parent in prison in Scotland, highlighting lessons for policy and practice
Signal transducer and activator of transcription-5 mediates neuronal apoptosis induced by inhibition of Rac GTPase activity.
In several neuronal cell types, the small GTPase Rac is essential for survival. We have shown previously that the Rho family GTPase inhibitor Clostridium difficile toxin B (ToxB) induces apoptosis in primary rat cerebellar granule neurons (CGNs) principally via inhibition of Rac GTPase function. In the present study, incubation with ToxB activated a proapoptotic Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway, and a pan-JAK inhibitor protected CGNs from Rac inhibition. STAT1 expression was induced by ToxB; however, CGNs from STAT1 knock-out mice succumbed to ToxB-induced apoptosis as readily as wild-type CGNs. STAT3 displayed enhanced tyrosine phosphorylation following treatment with ToxB, and a reputed inhibitor of STAT3, cucurbitacin (JSI-124), reduced CGN apoptosis. Unexpectedly, JSI-124 failed to block STAT3 phosphorylation, and CGNs were not protected from ToxB by other known STAT3 inhibitors. In contrast, STAT5A tyrosine phosphorylation induced by ToxB was suppressed by JSI-124. In addition, roscovitine similarly inhibited STAT5A phosphorylation and protected CGNs from ToxB-induced apoptosis. Consistent with these results, adenoviral infection with a dominant negative STAT5 mutant, but not wild-type STAT5, significantly decreased ToxB-induced apoptosis of CGNs. Finally, chromatin immunoprecipitation with a STAT5 antibody revealed increased STAT5 binding to the promoter region of prosurvival Bcl-xL. STAT5 was recruited to the Bcl-xL promoter region in a ToxB-dependent manner, and this DNA binding preceded Bcl-xL down-regulation, suggesting transcriptional repression. These data indicate that a novel JAK/STAT5 proapoptotic pathway significantly contributes to neuronal apoptosis induced by the inhibition of Rac GTPase
Nutrition Strategies for Triathlon
Contemporary sports nutrition guidelines recommend that each athlete develop a personalised, periodised and practical approach to eating that allows him or her to train hard, recover and adapt optimally, stay free of illness and injury and compete at their best at peak races. Competitive triathletes undertake a heavy training programme to prepare for three different sports while undertaking races varying in duration from 20 min to 10 h. The everyday diet should be adequate in energy availability, provide CHO in varying amounts and timing around workouts according to the benefits of training with low or high CHO availability and spread high-quality protein over the day to maximise the adaptive response to each session. Race nutrition requires a targeted and well-practised plan that maintains fuel and hydration goals over the duration of the specific event, according to the opportunities provided by the race and other challenges, such as a hot environment. Supplements and sports foods can make a small contribution to a sports nutrition plan, when medical supplements are used under supervision to prevent/treat nutrient deficiencies (e.g. iron or vitamin D) or when sports foods provide a convenient source of nutrients when it is impractical to eat whole foods. Finally, a few evidence-based performance supplements may contribute to optimal race performance when used according to best practice protocols to suit the triathleteâs goals and individual responsiveness
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