Concert recording 2018-04-23

[Track 1]. Solitudine avvenne, from Cantata / Alessandro Scarlatti -- [Track 2]. Airs Chantes. I. Air Romantique ; II. Air Cham petre ; III. Air Grave ; IV. Air Vif / Francis Poulenc -- [Track 3]. Der Hirt auf dem Felsen, op.129 / Franz Schubert -- [Track 4]. Natural Selection. I. Creation ; II. Animal passion ; Jake Heggie -- [Track 5]. Vado rna dove? Oh Dei! KV583 / Wolfgang Amadeus Mozart -- [Track 6]. Ah! Tardai troppo...O luci di quest\u27anima, from Linda di Chamounix / Gaetano Donizetti

Physics-constrained robust learning of open-form PDEs from limited and noisy data

Unveiling the underlying governing equations of nonlinear dynamic systems remains a significant challenge, especially when encountering noisy observations and no prior knowledge available. This study proposes R-DISCOVER, a framework designed to robustly uncover open-form partial differential equations (PDEs) from limited and noisy data. The framework operates through two alternating update processes: discovering and embedding. The discovering phase employs symbolic representation and a reinforcement learning (RL)-guided hybrid PDE generator to efficiently produce diverse open-form PDEs with tree structures. A neural network-based predictive model fits the system response and serves as the reward evaluator for the generated PDEs. PDEs with superior fits are utilized to iteratively optimize the generator via the RL method and the best-performing PDE is selected by a parameter-free stability metric. The embedding phase integrates the initially identified PDE from the discovering process as a physical constraint into the predictive model for robust training. The traversal of PDE trees automates the construction of the computational graph and the embedding process without human intervention. Numerical experiments demonstrate our framework's capability to uncover governing equations from nonlinear dynamic systems with limited and highly noisy data and outperform other physics-informed neural network-based discovery methods. This work opens new potential for exploring real-world systems with limited understanding

Concert recording 2017-11-20b

[Track 1]. Soccorrete, luci avare , op. 2 from La Travagliata [Track 2]. Spesso per entro al petto , op. 2 from La Fanciuletta semolice / Barbara Strozzi -- [Track 3]. Exultate, jubilate KV 165. I. Allegro [Track 4]. II. Andante III. Allegro / Wolfgang Amadeus Mozart -- [Track 5]. From Mörike-Lieder. Verborgenheit , op. 1 no. 11 [Track 6]. Nimmersatte, Liebe , op. 19 no. 19 [Track 7]. Er ist\u27s , op. 79 no. 23 / Hugo Wolf -- [Track 8]. Three songs. I. Insomnia & so on [Track 9]. II. You [Track 10]. III. Drifting at midday / Ching-chu Hu -- [Track 11]. Kommt ein schlanker bursch gegangen from Der Freischütz / Carl Maria von Weber -- [Track 12]. Ah! Je ris de me voir si belle en ce miroir from Faust / Charles Gounod

Concert recording 2015-12-06

[Track 01]. Lachen und Weinen / Franz Schubert -- Zitronenfalter im April / Hugo Wolf -- [Track 02]. Ganymed / Franz Schubert -- [Track 03]. Gesang Weylas / Hugo Wolf -- [Track 04]. An Silvia / Franz Schubert -- [Track 05]. Der Gärtner / Hugo Wolf -- [Track 06]. Gott im Frühling / Franz Schubert -- [Track 07]. Elfenlied / Hugo Wolf -- [Track 08]. Schäfers Klagelied / Franz Schubert -- [Track 09]. Verborgenheit / Hugo Wolf -- [Track 10]. Gretchens Bitte / Franz Schubert -- [Track 11]. Die Zigeunerin / Hugo Wolf -- [Track 12]. Liebesbotschaft / Franz Schubert -- [Track 13]. In dem Schatten meiner Locken / Hugo Wolf -- [Track 14]. Die junge Nonne / Franz Schubert -- [Track 15]. Nimmersatte Liebe / Hugo Wolf -- [Track 16]. Liebe schwärmt auf allen Wegen / Franz Schubert -- [Track 17]. Er ist\u27s / Hugo Wolf -- [Track 18]. Der Musensohn / Franz Schubert -- [Track 19]. Storchenbotschaft / Hugo Wolf

Concert recording 2018-04-16

[Track 1]. Music for a while / Henry Purcell -- [Track 2]. Lachen und Weinen / Franz Schubert -- [Track 3]. Sebben crudele / Antonio Caldara -- [Track 4]. Money, o! / Michael Head -- [Track 5]. Les Berceaux / Gabriel Fauré -- [Track 6]. Music I heard with you / Richard Hageman -- [Track 7]. Die Forelle / Schubert -- [Track 8]. Take, o take those lips away / Roger Quilter -- [Track 9]. La pastorella delle Alpi / Gioachino Rossini -- [Track 10]. Pastorale / Georges Bizet -- [Track 11]. Laudamus te from Mass in C minor, K. 427 / Wolfgang Amadeus Mozart -- [Track 12]. Winter / Dominick Argento -- [Track 13]. From Canciones clásicos españos. I. La mi sola, Laureola II. Al amor III. ¿Corazón porqué pasáis IV. Chiquitita la novia / Fenando Obradors -- [Track 14]. From Lieder und Gesänge aus Wilhelm Meister, op. 98a. Kennst du das Land Nur Wer die Sehnsucht kennt Heiss mich nicht reden, heiss mich schweigen / Robert Schumann -- [Track 15]. Non t\u27accostar all\u27urna / Schubert Non t\u27accostar all\u27urna / Giuseppe Verdi -- Плач об умершем младенце / Dmitri Shostakovich -- [Track 16]. Airs Chantés. I. Air Romantique II. Air Champêtre III. Air Grave IV. Air Vif / Francis Poulenc

Concert recording 2018-05-14

[Track 1]. Impresiones de la Puna / Alberto E. Ginastera -- [Track 2]. Sextet for piano and woodwind quintet FP 100 / Francis Poulenc -- [Track 3]. Cantata. Solitudine Avvenne / Alessandro Scarlatti -- [Track 4]. Suite for flute and jazz piano trio / Claude Bolling

Concert recording 2017-11-07

[Track 1]. Sitzzoso, mio stizzoso / Giovanni Pergolesi -- [Track 2]. Widmung / Robert Schumann -- [Track 3]. The roadside fire / Ralph Vaughan Williams -- [Track 4]. La promessa / Gioachino Rossini -- [Track 5]. Non é ver / Tito Mattei -- [Track 6]. Les Chemins d\u27amour / Francis Poulenc -- [Track 7]. Una donna a quindici anni from Cosi fan tutte / Wolfgang Amadeus Mozart -- [Track 8]. Non più andrai from The marriage of Figaro / Mozart -- [Track 9]. Botschaft / Johannes Brahms -- [Track 10]. Du bist die Ruh / Franz Schubert -- [Track 11]. Gualitier Maldè...Caro nome from Reigoletto / Giuseppe Verdi -- [Track 12]. Mondnacht / Robert Schumann -- [Track 13]. Les Roses d\u27Ispahan / Gabriel Fauré -- [Track 14]. An Chloe / Mozart -- [Track 15]. Sogno / Francesco Tosti -- [Track 16]. Er ist\u27s / Hugo Wolf -- [Track 17]. Ah, je ris de me voir from Faust / Charles Gounod -- [Track 18]. Claire du lune / Claude Debussy -- [Track 19]. Kling! / Richard Strauss -- [Track 20]. Erstarrung / Schubert -- [Track 21]. I\u27m glad I\u27m not a tenor / Ben Moore -- -- [Track 22]. Apparition / Debussy

Adverse drug events associated with linezolid administration: a real-world pharmacovigilance study from 2004 to 2023 using the FAERS database

Introduction: Linezolid is an oxazolidinone antibiotic that is active against drug-resistant Gram-positive bacteria and multidrug-resistant Mycobacterium tuberculosis. Real-world studies on the safety of linezolid in large populations are lacking. This study aimed to determine the adverse events associated with linezolid in real-world settings by analyzing data from the US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS).Methods: We retrospectively extracted reports on adverse drug events (ADEs) from the FAERS database from the first quarter of 2004 to that of 2023. By using disproportionality analysis including reporting odds ratio (ROR), proportional reporting ratio (PRR), Bayesian Confidence Propagation Neural Network (BCPNN), along with the multi-item gamma Poisson shrinker (MGPS), we evaluated whether there was a significant association between linezolid and ADE. The time to onset of ADE was further analyzed in the general population and within each age, weight, reporting population, and weight subgroups.Results: A total of 11,176 reports of linezolid as the “primary suspected” drug and 263 significant adverse events of linezolid were identified, including some common adverse events such as thrombocytopenia (n = 1,139, ROR 21.98), anaemia (n = 704, ROR 7.39), and unexpected signals that were not listed on the drug label such as rhabdomyolysis (n = 90, ROR 4.33), and electrocardiogram QT prolonged (n = 73, ROR 4.07). Linezolid-induced adverse reactions involved 27 System Organ Class (SOC). Gender differences existed in ADE signals related to linezolid. The median onset time of all ADEs was 6 days, and most ADEs (n = 3,778) occurred within the first month of linezolid use but some may continue to occur even after a year of treatment (n = 46).Conclusion: This study reports the time to onset of adverse effects in detail at the levels of SOC and specific preferred term (PT). The results of our study provide valuable insights for optimizing the use of linezolid and reducing potential side effects, expected to facilitate the safe use of linezolid in clinical settings

Purification and Characterization of a Novel α-L-Rhamnosidase from <i>Papiliotrema laurentii</i> ZJU-L07 and Its Application in Production of Icariin from Epimedin C

Icariin is the most effective bioactive compound in Herba Epimedii. To enhance the content of icariin in the epimedium water extract, a novel strain, Papiliotrema laurentii ZJU-L07, producing an intracellular α-L-rhamnosidase was isolated from the soil and mutagenized. The specific activity of α-L-rhamnosidase was 29.89 U·mg−1 through purification, and the molecular mass of the enzyme was 100 kDa, as assayed by SDS-PAGE. The characterization of the purified enzyme was determined. The optimal temperature and pH were 55 °C and 7.0, respectively. The enzyme was stable in the pH range 5.5–9.0 for 2 h over 80% and the temperature range 30–40 °C for 2 h more than 70%. The enzyme activity was inhibited by Ca2+, Fe2+, Cu2+, and Mg2+, especially Fe2+. The kinetic parameters of Km and Vmax were 1.38 mM and 24.64 μmol·mg−1·min−1 using pNPR as the substrate, respectively. When epimedin C was used as a nature substrate to determine the kinetic parameters of α-L-rhamnosidase, the values of Km and Vmax were 3.28 mM and 0.01 μmol·mg−1·min−1, respectively. The conditions of enzymatic hydrolysis were optimized through single factor experiments and response surface methodology. The icariin yield increased from 61% to over 83% after optimization. The enzymatic hydrolysis method could be used for the industrialized production of icariin. At the same time, this enzyme could also cleave the α-1,2 glycosidic linkage between glucoside and rhamnoside in naringin and neohesperidin, which could be applicable in other biotechnological processes