Environmental certification in a differentiated duopoly

The articleaims to explore the role of horizontal product differentiation in promoting/hindering firm’s participation in environmental certification. To this purpose, we consider a differentiated duopoly model where firms compete in both prices and environmental qualities. The result shows that when the level of horizontal differentiation relative to the degree of vertical differentiation is sufficiently high, only the symmetric equilibrium where both firms choose to or both choose not to certify their products exists. Asymmetric equilibrium (vertical dominance equilibrium) occurs when the level of horizontal differentiation relative to the degree of vertical differentiation is sufficiently low

Carbon Nanomaterial Manufacturing System and Automatic Synthesis Equipment and Its Control Device and Control Methods

In recent years, people are committed to developing new technologies and technologies for energy storage and conversion, environmental detection, high-performance sensors and energy security, and other aspects of the increasingly prominent problems in the field of environmental and biosafety. The purpose of this paper is to explore the manufacturing system and automatic synthesis equipment of carbon nanomaterials, understand the control device and control method, and analyze the structure and morphology characteristics of three kinds of carbon nanomaterials produced by carbon nanomaterial manufacturing system by X-ray diffraction and infrared spectroscopy. The results show that the carbon nanomaterial manufacturing system and automatic synthesis system in this paper solve the problems of high cost, low efficiency, and small scale of the existing carbon nanomaterials manufacturing and achieve the precision control of automatic production, so that the productivity is increased by 20%–35%, and the cost is reduced by 15%–30%. Therefore, they are widely used in the fields of science and technology, environmental protection, and intelligent manufacturing broad prospects. Carbon nanotube manufacturing equipment and automatic synthesis equipment have great production advantages, which can greatly improve the quality and efficiency of carbon nanomaterials. UPY, GO, and UGO carbon nanomaterials produced by carbon nanotube manufacturing equipment are not easy to fall off from the materials. When the wavelength is 500 nm, the absorption frequency of the three materials is the largest. With the extension of the spectral wavelength, the absorption frequency of the three materials is reduced by 52%, 33%, and 34.7%, respectively

CAR T-cell therapy for a relapsed/refractory acute B-cell lymphoblastic lymphoma patient in the context of Li-Fraumeni syndrome

Background Li-Fraumeni syndrome (LFS) is characterized as an autosomal dominant cancer predisposition disorder caused by germline TP53 gene mutations. Both primary and therapy-related hematopoietic malignancies with LFS are associated with dismal outcomes with standard therapies and even allogenic stem cell transplantation (SCT).Case presentation We reported a relapsed/refractory acute B-cell lymphoblastic lymphoma (B-LBL) patient in the context of LFS. He was identified to harbor a TP53 c.818G>A (p.R273H) germline mutation, and his family history was significant for rectal carcinoma in his father, an unknown cancer in his sister and acute lymphoblastic leukemia in his brother and one of his sons. The patient received murine monoclonal anti-CD19 and anti-CD22 chimeric antigen receptor (CAR) T-cell “cocktail” therapy and achieved complete remission with negative minimal residual disease (MRD), as assessed by morphology and multiparameter flow cytometry. Fifteen months after murine monoclonal CAR T-cell “cocktail” therapy, the patient’s B-LBL recurred. Fortunately, a round of fully human monoclonal anti-CD22 CAR T-cell therapy was still effective in this patient, and he achieved CR again and continued to be followed. Each time after infusion, the CAR T-cells underwent extremely rapid exponential expansion, which may be due to the disruption of TP53, a gene that can functionally control cell cycle arrest. Grade 4 and grade 1 cytokine release syndrome occurred after the first and second rounds of CAR T-cell therapy, respectively.Conclusions This case provides the first report of the use of CAR T-cell therapy in a hematologic malignancy patient with LFS. As traditional chemotherapy and allogenic SCT are not effective therapy strategies for patients with hematologic malignancies and LFS, CAR T-cell therapy may be an alternate choice.ChiCTR-OPN-16008526 and ChiCTR1900023922

Liraglutide, a TFEB-Mediated Autophagy Agonist, Promotes the Viability of Random-Pattern Skin Flaps

Random skin flaps are commonly used in reconstruction surgery. However, distal necrosis of the skin flap remains a difficult problem in plastic surgery. Many studies have shown that activation of autophagy is an important means of maintaining cell homeostasis and can improve the survival rate of flaps. In the current study, we investigated whether liraglutide can promote the survival of random flaps by stimulating autophagy. Our results show that liraglutide can significantly improve flap viability, increase blood flow, and reduce tissue oedema. In addition, we demonstrated that liraglutide can stimulate angiogenesis and reduce pyroptosis and oxidative stress. Through immunohistochemistry analysis and Western blotting, we verified that liraglutide can enhance autophagy, while the 3-methylladenine- (3MA-) mediated inhibition of autophagy enhancement can significantly reduce the benefits of liraglutide described above. Mechanistically, we showed that the ability of liraglutide to enhance autophagy is mediated by the activation of transcription factor EB (TFEB) and its subsequent entry into the nucleus to activate autophagy genes, a phenomenon that may result from AMPK-MCOLN1-calcineurin signalling pathway activation. Taken together, our results show that liraglutide is an effective drug that can significantly improve the survival rate of random flaps by enhancing autophagy, inhibiting oxidative stress in tissues, reducing pyroptosis, and promoting angiogenesis, which may be due to the activation of TFEB via the AMPK-MCOLN1-calcineurin signalling pathway