Feasibility of Modified Surviving Sepsis Campaign Guidelines in a Resource-Restricted Setting Based on a Cohort Study of Severe S. Aureus Sepsis

[This corrects the article on p. e29858 in vol. 7.]

Other supportive therapy in a resource-limited setting.

<p>Other supportive therapy in a resource-limited setting.</p

Hemodynamic support and adjunctive therapy of severe sepsis in a resource-limited setting.

<p>Hemodynamic support and adjunctive therapy of severe sepsis in a resource-limited setting.</p

Spiritual well-being and its relationship with patient characteristics and other patient-reported outcomes in peritoneal dialysis patients: Findings from the PDOPPS

BackgroundSpiritual well-being (SWB), an individual's understanding of the meaning and purpose of life, may help patients with chronic or terminal illnesses cope with their diseases. This study aimed to assess SWB in patients on peritoneal dialysis (PD), as well as its relationship with patient characteristics and patient-reported outcomes (PRO).MethodsThe data were obtained from questionnaires that formed part of the PD Outcomes and Practice Patterns Study (PDOPPS). Measures used in this study were SWB scores derived from the WHO quality of life, spirituality, religiousness and personal beliefs (WHOQOL-SRPB) tool including 32 items from eight facets; physical (PCS) and mental component summary (MCS) scores of the 12-Item Short-Form Health Survey (SF-12), Center of Epidemiologic Studies Depression Scale-10 (CES-D-10) scores, burden of kidney disease scores and functional status scores.ResultsOverall, 529 out of 848 participants (62%) completely responded to the questionnaires and were included in the analysis. Over two-thirds of PD patients (70%) had moderate or higher SWB scores. The SWB scores were significantly lower in patients with age >65 years and unemployed status. SWB scores positively correlated with higher PCS, MCS, burden of kidney disease scores and functional status scores, while negatively correlated with depression scores by CES-D-10 scale. Patients who reported significant depressive symptoms (CES-D-10 score ≥ 10) had significantly lower SWB scores.ConclusionBetter SWB was significantly associated with better health-related QOL (HRQOL) and the absence of depressive symptoms. SWB may be an essential consideration in the delivery of high-quality PD

Diagnostic criteria used for organ dysfunction.

<p>Criteria were from the literature <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029858#pone.0029858-Bone1" target="_blank">[1]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029858#pone.0029858-Levy1" target="_blank">[2]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029858#pone.0029858-Goldstein1" target="_blank">[27]</a> to fit the available data. Acute oliguria was determined from 24-hour urine because hourly urine output was infrequently monitored. Diagnostic criteria of arterial hypoxaemia (PaO₂/FiO₂<300), ileus, and clinical signs of tissue hypoperfusion (decrease capillary refill or mottling) were not used as data were not recorded in the patient records. Laboratory testing for lactate level was not available in the hospital. The Glasgow Coma Score was not documented in patient records.</p

Management and outcome of 72 patients with severe sepsis.

<p>When not shown the patient denominator is 72. Where the denominator differs from this for a particular question, these are shown.</p

Predictors and outcomes of peritoneal dialysis-related infections due to filamentous molds (MycoPDICS).

IntroductionWe sought to evaluate the predictors and outcomes of mold peritonitis in patients with peritoneal dialysis (PD).MethodsThis cohort study included PD patients from the MycoPDICS database who had fungal peritonitis between July 2015-June 2020. Patient outcomes were analyzed by Kaplan Meier curves and the Log-rank test. Multivariable Cox proportional hazards model regression was used to estimating associations between fungal types and patients' outcomes.ResultsThe study included 304 fungal peritonitis episodes (yeasts n = 129, hyaline molds n = 122, non-hyaline molds n = 44, and mixed fungi n = 9) in 303 patients. Fungal infections were common during the wet season (p ConclusionNon-hyaline-mold peritonitis had worse survival. Longer duration and higher daily dosage of antifungal treatment were associated with better survival. Deviations from the 2016 ISPD Peritonitis Guideline recommendations concerning treatment duration and catheter removal timing were independently associated with higher mortality