2 research outputs found

    sj-docx-1-jbr-10.1177_07487304241232447 – Supplemental material for Circadian Variation in the Response to Vaccination: A Systematic Review and Evidence Appraisal

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    Supplemental material, sj-docx-1-jbr-10.1177_07487304241232447 for Circadian Variation in the Response to Vaccination: A Systematic Review and Evidence Appraisal by Cathy A. Wyse, Laura M. Rudderham, Enya A. Nordon, Louise M. Ince, Andrew N. Coogan and Lorna M. Lopez in Journal of Biological Rhythms</p

    Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

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    Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in one second (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (Phase 1) imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5x10-8) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1, AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered
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