16 research outputs found
Spontaneous pneumomediastinum in Covid-19 : a case of complete resolution despite invasive positive pressure ventilation
Speech characteristics in children with congenital hemiplegia
Cover Photo Credit: Dick Smith
IN THIS ISSUE:
2 New Optimism for Growth, General Superintendent: Charles H. Strickland
3 Turning Wine into Water, Robert E. Maner
4 Letters
5 A Holy Character , Albert J. Lown
6 Seven Hours for a Scarf, Miriam Hall
8 Forgiveness (a poem), Linda Bagshaw
8 A Tribute to Colonel Harland Sanders, Don Ballard
9 The Honored Place (a poem), Chris Grauman
10 Chickens Don\u27t Fly, Richard A. Miller
11 Nazarene Roots: In the Indian Territory
11 Nazarenes and the Wesleyan Mission, Timothy L. Smith
12 Are They Coming Back?, Jayne Schooler
14 Involvement: The Church\u27s Number One Need, John W. May
15 Success, J. Grant Swank, Jr.
16 Nashville Conference Heralds Heritage of Urban Ministry, R. Franklin Cook
18 The Editor\u27s Standpoint
20 By All Means, Fred Wenger
21 In the News
30 News of Religion
31 Answer Corner
34 Late News
35 My Prayer (a poem), Geraldine Nicholashttps://digitalcommons.olivet.edu/cotn_hoh/1311/thumbnail.jp
Neuron-specific enolase and bispectral index/suppression ratio for prognostication after cardiac arrest
Exposure to intravenous posaconazole in critically ill patients with influenza: A pharmacokinetic analysis of the POSA-FLU study
BACKGROUND: Data on posaconazole in the critically ill are scarce. In the POSA-FLU study, we examined the prevention of influenza-associated pulmonary aspergillosis with posaconazole in this population. METHODS: In this observational sub-study, we performed a pharmacokinetic analysis, including protein binding and target attainment (TA). Blood samples were collected over a 24 h-dosing interval on both an early (Day 2 or 3) and a later (≥Day 4) treatment day. RESULTS: Target attainment was shown for AUC(0-24) and C(min) prophylaxis but not for C(min) treatment. Moreover, a saturable protein binding with a significant, positive relationship between albumin concentrations and the maximum binding capacity was observed. CONCLUSIONS: Our analysis indicates that posaconazole may be a suitable drug to further investigate for prophylaxis, as TA for prophylaxis was reached. Exposure targets for treatment were insufficiently attained in this population