302 research outputs found

    Estudio espectrofotométrico y espectrofluorométrico de la reacción de azucares con el ácido cromotrópico en medio sulfúrico. II. – Comportamiento de las metil-pentosas

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    Se hace un estudio de la reacción de la sal sódica del ácido cromotrópico en medio sulfúrico con el metil-furfurbl originado por la ramnosa y la fucosa al ser tratados estos dos azúcares con el ácido sulfúrico. La gráfica espectral de ambos productos de condensación permite la identificación y diferenciación de estas dos 6-deoxi-hesosas, por presentar a todas las concrentraciones ensayadas un máximo a 460 nm. superior al originado a 260 nm en el caso de la ramnosa, mientras que el máximo a 460 nm que origina la fucosa es siempre de menor altura que el de 260 nm. Se da la in.terpretación de acuerdo con los resultados experimentales. Se han determinado los coeficientes de extinción y las constantes de equilibrio aparentes. También se ha hecho un restudio espectrofluorométrico de la reacción.A study is made of the reaction oí the sodium salt of chromotropic acid in a sulphuric acid medium with methyIfurfural produced by rhamnose and fucose when these two sugars are treated with sulphuric acid. The spectral graph of both products of condensation allows the idenHfication and differentiation of these two 6-deoxi-hesoses, dure to their showing at a11 the concentrations tested a maximum to 460 nm higher than ,that originated at 260 nm in thoe case of rhamnose, while the maximum at 460 nm which fucose causes is always less than that of 260 nm. The interpretation has been made in accordance with the experimental results. The extinction coefficients and the equilibrium conditional constants has been determined. A spectrofluometric study is made of the reaction also

    Time of the day of exercise impact on cardiovascular disease risk factors in adults: a systematic review and meta-analysis

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    Objectives: To compare the effect of a single bout of morning vs. evening exercise on cardiovascular risk factors in adults. Design: Systematic review and meta-analysis. Methods: A systematic search of studies was conducted using PubMed andWeb of Science from inception to June 2022. Selected studies accomplished the following criteria: crossover design, acute effect of exercise, blood pressure, blood glucose, and/or blood lipids as the study's endpoint, awashout period of at least 24 h, and adults.Meta-analysis was performed by analyzing: 1) separated effect of morning and evening exercise (pre vs. post); and 2) comparison between morning and evening exercise. Results: A total of 11 studies were included for systolic and diastolic blood pressure and 10 studies for blood glucose. Meta-analysis revealed no significant difference between morning vs. evening exercise for systolic blood pressure (g Δ=0.02), diastolic blood pressure (g Δ=0.01), or blood glucose (g Δ=0.15). Analysis of moderator variables (age, BMI, sex, health status, intensity and duration of exercise, and hour within the morning or evening) showed no significant morning vs. evening effect. Conclusions: Overall, we found no influence of the time of the day on the acute effect of exercise on blood pressure neither on blood glucose.Spanish Government FPU19/0374

    Enzyme-Powered Gated Mesoporous Silica Nanomotors for On-Command Intracellular Payload Delivery

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    [EN] The introduction of stimuli-responsive cargo release capabilities on self-propelled micro- and nano- motors holds enormous potential in a number of applications in the biomedical field. Herein, we report the preparation of mesoporous silica nano-particles gated with pH-responsive supramolecular nanovalves and equipped with urease enzymes which act as chemical engines to power the nanomotors. The nanoparticles are loaded with different cargo molecules ([Ru(bpy)(3)]Cl-2 (bpy = 2,2'-bipyridine) or doxorubicin), grafted with benzimidazole groups on the outer surface, and capped by the formation of inclusion complexes between benzimidazole and cyclodextrin-modified urease. The nanomotor exhibits enhanced Brownian motion in the presence of urea. Moreover, no cargo is released at neutral pH, even in the presence of the biofuel urea, due to the blockage of the pores by the bulky benzimidazole:cyclodextrin-urease caps. Cargo delivery is only triggered on-command at acidic pH due to the protonation of benzimidazole groups, the dethreading of the supramolecular nanovalves, and the subsequent uncapping of the nanoparticles. Studies with HeLa cells indicate that the presence of biofuel urea enhances nanoparticle internalization and both [Ru(bpy)(3)]Cl-2 or doxorubicin intracellular release due to the acidity of lysosomal compartments. Gated enzyme-powered nanomotors shown here display some of the requirements for ideal drug delivery carriers such as the capacity to self-propel and the ability to "sense" the environment and deliver the payload on demand in response to predefined stimuli.A.L.-L. is grateful to La Caixa Banking Foundation for his Ph.D. grant. A.G.-F. thanks the Spanish government for her FPU fellowship. The authors are grateful to the Spanish Government (MINECO Projects MAT2015-64139-C4-1, CTQ2014-58989- PCTQ2015-71936-REDT, CTQ2015-68879-R (MICRODIA) and CTQ2015-72471-EXP (Enzwim)), the BBVA foundation (MEDIROBOTS), the CERCA Programme by the Generalitat de Catalunya, and the Generalitat Valenciana (Project PROMETEO/2018/024 and PROMETEOII/2014/061) for support. T.P. thanks MINECO for the Juan de la Cierva postdoctoral fellowship and the European Union's Horizon 2020 research and innovation program, under the Marie Sk¿odowska-Curie Individual Fellowship (H2020-MSCA-IF2018, DNA-bots). A.C.H. thanks MINECO for the Severo Ochoa fellowship. The authors would like to thank A. Miguel Lopez for the development of the python code for motion analysis.Llopis-Lorente, A.; García-Fernández, A.; Murillo-Cremaes, N.; Hortelao, A.; Patiño, T.; Villalonga, R.; Sancenón Galarza, F.... (2019). Enzyme-Powered Gated Mesoporous Silica Nanomotors for On-Command Intracellular Payload Delivery. ACS Nano. 13(10):12171-12183. https://doi.org/10.1021/acsnano.9b067061217112183131

    Dignity and psychosocial related variables in elderly advanced cancer patients

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    Abstract Introduction: Most cancers occur in older individuals, who are more vulnerable due to functional impairment, multiple comorbidities, cognitive impairment, and lack of socio‑familial support. These can undermine patients' sense of dignity. This study seeks to compare dignity scores in older patients with advanced cancer on sociodemographic and clinical variables and analyze the predictive value of anxiety, depression, functional limitations, and social support on dignity scores. Methods: A prospective, multicenter, observational study conducted with participation of 15 hospitals in Spain from February 2020 to October 2021. Patients with newly‑diagnosed, advanced cancer completed the dignity (PPDS), anxiety and depression (BSI), Social Support (Duke-UNC‑11), and functional limitations (EORTC‑C30) scales. Lineal regression analyses explored the effects of anxiety, depression, functional status, and social support on dignity, adjusting for sociodemographic and clinical variables. Results: A total of 180 subjects participated in this study. The results of the correlation analysis revealed that dignity correlated negatively with anxiety, depression, and sex, and positively with social support, functional status, and longer estimated survival. Thus, women, and more anxious and depressed individuals scored lower on the dignity scale, whereas patients with more social support, fewer functional limitations, and longer estimated survival scored higher. Conclusion: In conclusion, being female, having a lower educational level, lower estimated survival, depression, anxiety, less social support, and limited functionality are correlated with less dignity in the elderly with advanced cancer. It is a priority to manage both physical and psychological symptoms in patients with unresectable advanced cancer to mitigate psychological distress and increase their sense of dignit
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