Mediators of mechanotransduction between bone cells

Mechanical forces are known to regulate the function of tissues in the body, including bone. Bone adapts to its mechanical environment by altering its shape and increasing its size in response to increases in mechanical load associated with exercise, and by decreasing its size in response to decreases in mechanical load associated with microgravity or prolonged bed rest. Changes in bone size and shape are produced by a cooperative action of two main types of the bone cells - osteoclasts that destroy bone and osteoblasts that build bone. These cell types come from different developmental origins, and vary greatly in their characteristics, such as size, shape, and expression of receptor subtypes, which potentially may affect their responses to mechanical stimuli. The objective of this study is to compare the responses of osteoclasts and osteoblasts to mechanical stimulation. This study has allowed us to conclude the following: 1. A mediator is released from a single source cell. 2. The response to the mediator changes with distance. 3. The value of the apparent diffusion coeficient increases with distance. 4. A plausible proposed mechanism is that ATP is released and degrades to ADP. 5. Future experiments are required to confim that ATP is the mediator as suggested

A Layman's guide to SUSY GUTs

The determination of the most straightforward evidence for the existence of the Superworld requires a guide for non-experts (especially experimental physicists) for them to make their own judgement on the value of such predictions. For this purpose we review the most basic results of Super-Grand unification in a simple and clear way. We focus the attention on two specific models and their predictions. These two models represent an example of a direct comparison between a traditional unified-theory and a string-inspired approach to the solution of the many open problems of the Standard Model. We emphasize that viable models must satisfy {\em all} available experimental constraints and be as simple as theoretically possible. The two well defined supergravity models, $SU(5)$ and $SU(5)\times U(1)$, can be described in terms of only a few parameters (five and three respectively) instead of the more than twenty needed in the MSSM model, \ie, the Minimal Supersymmetric extension of the Standard Model. A case of special interest is the strict no-scale $SU(5)\times U(1)$ supergravity where all predictions depend on only one parameter (plus the top-quark mass). A general consequence of these analyses is that supersymmetric particles can be at the verge of discovery, lurking around the corner at present and near future facilities. This review should help anyone distinguish between well motivated predictions and predictions based on arbitrary choices of parameters in undefined models.Comment: 25 pages, Latex, 11 figures (not included), CERN-TH.7077/93, CTP-TAMU-65/93. A complete ps file (1.31MB) with embedded figures is available by request from [email protected]

Tunneling into fractional quantum Hall liquids

Motivated by the recent experiment by Grayson et.al., we investigate a non-ohmic current-voltage characteristics for the tunneling into fractional quantum Hall liquids. We give a possible explanation for the experiment in terms of the chiral Tomonaga-Luttinger liquid theory. We study the interaction between the charge and neutral modes, and found that the leading order correction to the exponent $\alpha$ $(I\sim V^\alpha)$ is of the order of $\sqrt{\epsilon}$ $(\epsilon=v_n/v_c)$, which reduces the exponent $\alpha$. We suggest that it could explain the systematic discrepancy between the observed exponents and the exact $\alpha =1/\nu$ dependence.Comment: Latex, 5 page

Probing 3-D matter distribution at z~2 with QSO multiple lines of sight

We investigate the 3-D matter distribution at z~2 with high resolution (R ~ 40000) spectra of QSO pairs and groups obtained with the UVES spectrograph at ESO VLT. Our sample is unique for the number density of objects and the variety of separations, between 0.5 and 7 proper Mpc. We compute the real space cross-correlation function of the Lyman-alpha forest transmitted fluxes. There is a significant clustering signal up to ~2 proper Mpc, which is still present when absorption lines with high column density (log N > 13.8) are excluded.Comment: Poster paper presented at the IAU Colloquium #199 on "Probing Galaxies through Quasar Absorption Lines" held in Shanghai, China from March 14th to 18th, 200

Spin filtering in nanowire directional coupler

The spin transport characteristics of a nanowire directional electronic coupler have been evaluated theoretically via a transfer matrix approach. The application of a gate field in the region of mixing allows for control of spin current through the different leads of the coupler via the Rashba spin-orbit interaction. The combination of spin-orbit interaction and applied gate voltages on different legs of the coupler give rise to a controllable modulation of the spin polarization. Both structural factors and field strength tuning lead to a rich phenomenology that could be exploited in spintronic devices.Comment: 9 pages, 4 figure

Planar laser induced fluorescence for temperature measurement of optical thermocavitation

Pulsed laser-induced cavitation, has been the subject of many studies describing bubble growth, collapse and ensuing shock waves. To a lesser extent, hydrodynamics of continuous wave (CW) cavitation or thermocavitation have also been reported. However, the temperature field around these bubbles has not been measured, partly because a sensor placed in the fluid would interfere with the bubble dynamics, but also because the short-lived bubble lifetimes (∼70–200 µs) demand high sampling rates which are costly to achieve via infrared (IR) imaging. Planar laser-induced fluorescence (PLIF) provides a non-intrusive alternative technique to costly IR imaging to measure the temperature around laser-induced cavitation bubbles. A 440 nm laser sheet excites rhodamine-B dye to fluoresce while thermocavitation is induced by a CW 810 nm laser. Post-calibration, the fluorescence intensity captured with a high-speed Phantom Miro camera is correlated to temperature field adjacent to the bubble. Using shadowgraphy and PLIF, a significant decrease in sensible heat is observed in the nucleation site– temperature decreases after bubble collapse and the initial heated volume of liquid shrinks. Based on irradiation time and temperature, the provided optical energy is estimated to be converted up to 50% into acoustic energy based on the bubble's size, with larger bubbles converting larger percentages

Tomography of the intergalactic medium with Ly-alpha forests in close QSO pairs

We study the three-dimensional distribution of non virialised matter at z~2 using high resolution spectra of QSO pairs and simulated spectra drawn from cosmological hydrodynamical simulations. We have collected the largest sample of QSO pairs ever observed with UVES at the ESO-VLT, with angular separations between ~1 and 14 arcmin. The observed correlation functions of the transmitted flux in the HI Lyman alpha forest along and transverse to the lines of sight are in good agreement implying that the distortions in redshift space due to peculiar velocities are small. The clustering signal is significant up to velocity separations of ~200 km/s, or about 3 h^{-1} comoving Mpc. The regions at lower overdensity (rho/ < 6.5) are still clustered but on smaller scales (Delta v < 100 km/s). The observed and simulated correlation functions are compatible at the 3 sigma level. A better concordance is obtained when only the low overdensity regions are selected for the analysis or when the effective optical depth of the simulated spectra is increased artificially, suggesting a deficiency of strong lines in the simulated spectra. We found that also a lower value of the power-law index of the temperature-density relation for the Lyman alpha forest gas improves the agreement between observed and simulated results. If confirmed, this would be consistent with other observations favouring a late HeII reionization epoch (at z~3). We remark the detection of a significant clustering signal in the cross correlation coefficient at a transverse velocity separation Delta v_{\perp} ~500 km/s whose origin needs further investigation.Comment: Accepted for publication in MNRAS, revised version matching the accepted on

Continuous-wave phase-sensitive parametric image amplification

We study experimentally parametric amplification in the continuous regime using a transverse-degenerate type-II Optical Parametric Oscillator operated below threshold. We demonstrate that this device is able to amplify either in the phase insensitive or phase sensitive way first a single mode beam, then a multimode image. Furthermore the total intensities of the amplified image projected on the signal and idler polarizations are shown to be correlated at the quantum level.Comment: 14 pages, 7 figures, submitted to Journal of Modern Optics, Special Issue on Quantum Imagin