12 research outputs found
Regulatory regions of the C elegans genome contain more low-affinity REF-1 transcription-factor binding sites than high-affinity sites
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Research priorities for exacerbations of COPD
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 14/05/2021
- Field of study
Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis
- Author
- A.K. Russell
- Aigner
- Appel
- Armstrong
- B.Y. Chan
- Beyer
- Blom
- Blom
- Bustin
- Bustin
- C.B. Little
- Choi
- Corr
- Deal
- Dell’accio
- Diarra
- E.S. Fuller
- Felson
- Glasson
- Grotewold
- Heiland
- Hoeppner
- J.F. Bateman
- Jackson
- Jacobsen
- Karlsson
- Karsdal
- Kawaguchi
- Kobayashi
- Krause
- Li
- Li
- Lin
- Little
- Little
- Little
- Little
- Liu
- Loots
- Lories
- M.A. Cake
- M.M. Smith
- M.T. Jackson
- P.N. Sambrook
- Power
- R.A. Read
- Robling
- Roos
- Ryu
- S.M. Smith
- Semenov
- Smith
- van Bezooijen
- van Bezooijen
- Vincent
- Voorzanger-Rousselot
- Weng
- Weng
- Young
- Yuasa
- Zhu
- Zhu
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
In Sffamily Identification of Genes in Bacteriophage DNA
- Author
- A. Bairoch
- A. Grigoriev
- A. Lukashin
- A. Marchler-Bauer
- A. Villegas
- A.C. Darling
- A.L. Delcher
- A.M. Cerdeno-Tarraga
- A.M. Cerdeno-Tarraga
- A.M. Kropinski
- B.G. Condron
- D. Laslett
- D. Lindell
- D. Nelson
- D. Scholl
- E. Quevillon
- E.C. Miller
- E.L.L. Sonnhammer
- E.S. Miller
- G.E. Christie
- G.G. Loots
- G.H. Domselaar Van
- G.J. Newton
- I. Ovcharenko
- J. Besemer
- J. Besemer
- J. Besemer
- J. Parkhill
- J. Reeder
- J. Shine
- J. Shine
- J.C. Abbott
- J.D. Bendtsen
- J.F. Seegers
- K. Rutherford
- K.W. Ng
- L.J. McGuffin
- L.M. Kattenhorn
- M. Borodovsky
- M. Landthaler
- M. Landthaler
- M. Zimmer
- M.A. Farinha
- M.A. Gregory
- M.B. Lobocka
- M.C. Smith
- M.E. Ford
- M.E. Levin
- M.J. Sibbald
- M.L. Pedulla
- N. Hulo
- N. Zafar
- N.H. Mann
- N.J. Mulder
- P.J. Farabaugh
- P.W. Lord
- R. Mazumder
- R. Mills
- R.L. Tatusov
- R.P. Bonocora
- R.W. Hendrix
- R.W. Hendrix
- S. Bocs
- S. Casjens
- S. Celamkoti
- S. Chibani-Chennoufi
- S. Foley
- S. O’Flaherty
- S. Rey
- S. Schwartz
- S.D. van
- S.F. Altschul
- S.F. Altschul
- S.L. Salzberg
- T. Kwan
- T. Yada
- T.J. Carver
- T.M. Lowe
- T.S. Larsen
- V. Kolla
- V. Lazarevic
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2009
- Field of study
Diversity of Fibroblasts – A Review on Implications for Skin Tissue Engineering
- Author
- Aoki S.
- Bayreuther K.
- Bayreuther K.
- Bell E.
- Bell E.
- Boyce S.
- Boyce S.T.
- Boyce S.T.
- Briggaman R.A.
- Bucala R.
- Burger A.
- Castor C.W.
- Chang H.Y.
- Chesney J.
- Clark R.A.F.
- Contard P.
- Cooper M.L.
- Cooper M.L.
- Curran M.P.
- Debacq-Chainiaux F.
- Eckes B.
- Eckes B.
- Falanga V.
- Fluck J.
- Germain L.
- Griffiths M.
- H. Peter Rodemann
- Hakenjos L.
- Hanft J.R.
- Hans-Oliver Rennekampff
- Hansbrough J.F.
- Hasan A.
- Herskind C.
- Kataoka K.
- Kearney J.N.
- Kern A.
- Kern A.
- Kessler D.
- Kraut J.D.
- Krejci N.C.
- Lamme E.N.
- Lamme E.N.
- Lamme E.N.
- Lara P.C.
- Lee K.Y.
- Limat A.
- Loots M.A.
- Maas-Szabowski N.
- Mansbridge J.N.
- Marston W.A.
- Middelkoop E.
- Mollenhauer J.
- Morocutti A.
- Morocutti A.
- Nakagawa S.
- Pascal T.
- Rinn J.L.
- Rodemann H.P.
- Rodemann H.P.
- Rodemann H.P.
- Rodemann H.P.
- Rodemann H.P.
- Rodemann H.P.
- Rossio-Pasquier P.
- Sahuc F.
- Satoh H.
- Sheridan R.L.
- Shipev C.C.
- Sonja Veronika Nolte
- Sorrell J.M.
- Stephens P.
- Van Zuijlen P.P.M.
- Von Pfeil A.
- Von Zglinicki T.
- Waelti E.R.
- Weiguo Xu
- Yamaguchi Y.
- Yang L.
- Publication venue
- 'S. Karger AG'
- Publication date
- 01/01/2008
- Field of study
Artificial Skin: Past, Present and Future
- Author
- Aubock J.
- Beele H.
- Beele H.
- Bell E.
- Benbow M.
- Billingham R.E.
- Boyce S.T.
- Boyce S.T.
- Bullard K.M.
- Burt A.
- Cairns B.A.
- Clarck R.A.F.
- Clark R.A.F.
- Cohen I.K.
- Compton C.C.
- Cooper M.L.
- Cuono C.
- Desmouliere A.
- Desmoulière A.
- Falanga V.
- Folkman J.
- Folkman J.
- Goliger J.A.
- Green H.
- Greiling D.
- Grey J.E.
- Hansborough J.F.
- Hansbrough J.F.
- Hansbrough J.F.
- Hansbrough J.F.
- Hefton J.M.
- Hefton J.M.
- Heldin C-H
- Herzog S.R.
- Hill J.
- Karasek M.
- Kreibich K.
- Leigh I.M.
- Loots M.A.
- Madden M.R.
- Madlener M.
- McGrath J.A.
- Medawar P.
- Monstrey S.
- Nanney L.B.
- Navsaria H.A.
- Nissen N.N.
- O'Connor N.E.
- Odeyssey R.
- Phillips L.G.
- Phillips T.J.
- Pilcher B.K.
- Prunieras M.
- Reverdin S.L.
- Rheinwald J.G.
- Risau W.
- Roberts A.B.
- Sabolinski M.L.
- Schulz J.T.
- Sheridan R.L.
- Singer A.J.
- Teepe R.G.C.
- Thivolet J.
- Tredget E.F.
- Vaalamo M.
- Verplancke P.
- Waymack P.
- Werner S.
- Wilkins L.M.
- Yannas I.V.
- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study
Teachers' Use of Memory-Box-Making to Provide Psychosocial Support in Their Pastoral Role
- Author
- Angrosino M.V.
- Babbie E.
- Babbie E.
- Berger E.H.
- Catlin G.
- Chabilall J.
- Christians C.G.
- Clandinin D.J.
- Coombe C.
- Cooper B.
- Corsini R. J.
- Cresswell J.W.
- De Vos A.S.
- De Witt M.W.
- Denis P.
- Denis P.
- Denscombe M.
- Denzin N.K.
- Denzin N.K.
- Departmentof Education.
- Departmentof Education.
- Ebersöhn L.
- Ebersöhn L.
- Ebersöhn L.
- Ebersöhn L.
- Edwards D. C.
- Ferrara M. M.
- Ferreira R.
- Foster G.
- Gibson K.
- Giese S.
- Hamm C. M.
- Hatch J.A.
- Hepburn A.E.
- Hunter S.
- Irin News
- Jamieson L.
- Leedy P.D.
- Loots T.
- Marshall C.
- McBride R.
- McCallaghan M.
- Miller R.
- Mnguni M.A.
- Morgan D.L.
- Morgan J.
- Mouton J.
- Ntsimane R.
- Ogina T.
- Powell D.
- Richter L.
- Schierhout G.
- Schurink W.J.
- Seale C.
- Sengendo J.
- Sinomlando Centre.
- Soul City.
- South African Institute for Distance Education (SAIDE)
- Swanepoel A.
- Tashakkorri A.
- UNAIDS.
- UNICEF.
- Urassa M.
- USAIDS
- USAIDS.
- Vaughn S.
- Viljoen R.
- Waddington K.
- Williamson J.
- Wilson T.
- Wolfelt D.
- Zappula C.
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Angiogenesis and Arteriogenesis in Diabetes Mellitus: Signal Transduction Defects as the Molecular Basis of Vascular Cell Dysfunction
- Author
- A. Abaci
- A. Babiak
- A. Bierhaus
- A. Goldin
- A. Gualandris
- A. Kosaki
- A. Melidonis
- A. Melidonis
- A. Neumann
- A. Parenti
- A. Rivard
- A. Rojas
- A. Schultz
- A.E. Buchs
- A.I. Adler
- A.L. Wong
- A.M. Schmidt
- A.M. Schmidt
- A.M. Schmidt
- A.P. Burke
- A.S. Charonis
- A.S. Krolewski
- A.W. Chung
- B. Balkau
- B. Vandenbunder
- B. Williams
- B. Xu
- B.M. Balletshofer
- C. Cipolletta
- C. Emanueli
- C. Emanueli
- C. Emanueli
- C. Emanueli
- C. Emanueli
- C. Emanueli
- C. Jiao
- C. Miele
- C. Stettler
- C. Suri
- C. Suri
- C. Takagi
- C. Tasca
- C. Tschope
- C.C. Juan
- C.G. Schalkwijk
- C.J. He
- C.J. Loomans
- C.S. Haitoglou
- D. Altavilla
- D. Deng
- D. Koya
- D. Koya
- D. Portilla
- D. Roth
- D. Weihrauch
- D. Yao
- D.B. Sacks
- D.G. Greenhalgh
- D.K. Wilson
- D.R. Tomlinson
- E. Chou
- E. Sivan-Loukianova
- E. Standl
- E.B. Okon
- E.C. Tsilibary
- E.J. Stelnicki
- E.P. Feener
- E.P. Feener
- E.Y. Yang
- F. Facchiano
- F. Fiordaliso
- F. Pipp
- F.E. Rey
- F.H. Seeger
- G. Arcaro
- G. Asano
- G. Basta
- G. Bouma
- G. Cantarella
- G. Ceolotto
- G. Graiani
- G. Zeng
- G.C. Schatteman
- G.M. Pieper
- G.P. Fadini
- G.P. Fadini
- G.R. Upchurch Jr
- G.S. Werner
- G.S. Werner
- G.W. Hart
- H. Kampfer
- H.J. Goldberg
- H.M. Lander
- H.N. Ginsberg
- H.O. Steinberg
- H.P. Hammes
- I. Duka
- I. Giardino
- I.G. Obrosova
- I.M. Stratton
- J. Asai
- J. El Khoury
- J. Folkman
- J. Kishimoto
- J. Koivunen
- J. Li
- J. Li
- J. Stark
- J. Waltenberger
- J. Waltenberger
- J. Waltenberger
- J.D. Luo
- J.H. Fuller
- J.I. Barzilay
- J.J. Piek
- J.L. Evans
- J.L. Wautier
- J.M. Kyriakis
- J.R. Williamson
- J.T. Kadonaga
- K. Cusi
- K. Hayashi
- K. Hirata
- K. Ikeda
- K. Kuboki
- K. Rzeczuch
- K.K. Hirschi
- K.P. Rentrop
- L. Calza
- L. Park
- L. Ravanti
- L.A. Cornelius
- L.A. Uyeno
- L.M. Coussens
- L.P. Aiello
- M. Bjornholm
- M. Brownlee
- M. Cohen
- M. Fujita
- M. Galeano
- M. Galeano
- M. Galeano
- M. Haneda
- M. Heil
- M. Kunisaki
- M. Montagnani
- M. Neeper
- M. Sezer
- M. Shinohara
- M. Stahle-Backdahl
- M. Vasa
- M.A. Hofmann
- M.A. Loots
- M.A. Loots
- M.B. Ganz
- M.B. Salis
- M.H. Cobb
- M.J. Mason
- M.J. Sheetz
- M.L. Ramirez
- M.P. Wautier
- M.S. Huijberts
- M.S. O’reilly
- M.S. Segal
- M.T. Kearney
- M.T. Kearney
- M.U. Ahmed
- N. Ahmed
- N. Boudreau
- N. Tanji
- N.H. Pijls
- N.J. Trengove
- N.T. Sepp
- O. Awad
- O. Hori
- O.M. Tepper
- O.Z. Lerman
- P Carmeliet
- P. Fernyhough
- P. Fernyhough
- P. Porcu
- P. Quehenberger
- P. Stephens
- P. Xia
- P.A. Craven
- P.A. Craven
- P.C. Brooks
- P.C. Maisonpierre
- P.J. Keck
- P.J. Nahser Jr
- P.J. Thornalley
- P.T. Donnan
- R. Bucala
- R. Gum
- R. Morishita
- R. Ramasamy
- R. Tamarat
- R. Tamarat
- R. Yarom
- R. Zbinden
- R.A. Defronzo
- R.D. Galiano
- R.G. Paul
- R.G. Tilton
- R.J. Keogh
- R.J. Stevens
- R.K. Studer
- S. Jesmin
- S. Kanda
- S. Nakamura
- S. Reddy
- S. Romano Di Peppe
- S. Schiekofer
- S. Schiekofer
- S. Shintani
- S. Vehkavaara
- S. Yamagishi
- S.D. Yan
- S.F. Yan
- S.J. Cleland
- S.J. Wall
- S.K. Grandhee
- S.L. Hansen
- S.L. Hansen
- S.M. Haffner
- S.S. Chung
- T. Asahara
- T. Inoguchi
- T. Inoguchi
- T. Inoue
- T. Itoh
- T. Kislinger
- T. Kislinger
- T. Kobayashi
- T. Miyata
- T. Takahashi
- T.J. Guzik
- U. Chakravarthy
- U. Hink
- U. Ritthaler
- V. Falanga
- V. Kolm-Litty
- V.M. Altan
- V.M. Monnier
- W. Schaper
- W. Wang
- W.A. Hsueh
- X.L. Du
- Y. Nisanci
- Y. Taniyama
- Y. Taniyama
- Y.C. Shyng
- Y.Q. Chen
- Z.S. Kyriakides
- Z.Y. Jiang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2007
- Field of study
The ASOS Surgical Risk Calculator: development and validation of a tool for identifying African surgical patients at risk of severe postoperative complications
- Author
- A. Abd-rouf
- A. Abduljalil
- A. Abdulrahman
- A. Abokris
- A. Abushnaf
- A. Addanfour
- A. Alatresh
- A. Alfari
- A. Alfetore
- A. Algddar
- A. Alghazali
- A. Alhendery Alhendery
- A. Ali
- A. Ali
- A. Alkilani
- A. Alli
- A. Almajbery
- A. Alsayed
- A. Anele
- A. Attia
- A. Basenero
- A. Berhe
- A. Bogoslovskiy
- A. Dasrath
- A. Dodiyi-Manuel
- A. Ehouni
- A. Elmgadmi
- A. Elshikhy
- A. Elwerfelli
- A. Feituri
- A. Gakenia
- A. Ganesh
- A. Garrido Lopez
- A. Ghnain
- A. Hdud
- A. Ibrahim Abdelatif
- A. Issoufou
- A. Jaber
- A. Juwid
- A. Khamajeet
- A. Maharaj
- A. Maharaj
- A. Mallier Peter
- A. Manneh
- A. Mansour
- A. Metali
- A. Mlotshwa
- A. Mohamed
- A. Mohamed
- A. Mohamed
- A. Mohamed
- A. Mohamed
- A. Muturi
- A. Mwale
- A. Nansook
- A. Onyegbule
- A. Prosper
- A. Rabemazava
- A. Sarkin-Pawa
- A. Shubba
- A. Sohoub
- A. Steyn
- A. Swaleh
- A. Tarhuni
- A. Thotharam
- A. Wafa
- A. Wafula
- A. Zidan
- A. Zo
- A.A. Alraheem
- A.A. Altagazi
- A.A. Aribi
- A.A. Eshwehdi
- A.A. Kornilov
- A.A. Munyika
- A.A. Sheshe
- A.A. Yahya
- A.A. Yunus
- A.A.G. Gomati
- A.B. Muhammad
- A.B. Zerihun
- A.C. Castro
- A.D. Aldarrat
- A.D. Maharaj
- A.E.T. Ayebale
- A.F.X. Agaba
- A.G.B. Andriamampionona
- A.G.L. Rocher
- A.H. Harissou
- A.H. Hery
- A.H.N. Rakotoarisoa
- A.H.R. Rakotoarijaona
- A.I. Ibrahim
- A.I. Levin
- A.I. Yahya
- A.J. Szpytko
- A.J. Vermeulen
- A.J.M. Lumbamba
- A.K. Egote
- A.K. Kintu
- A.K. Koledale
- A.L. AL Samateh
- A.L. Samateh
- A.M. Baloyi
- A.M. Elghallal
- A.M. Elghobashy
- A.M. Elzufri
- A.M. Iraya
- A.M. Kilembe
- A.M. Kukembila
- A.M. Macheka
- A.M. Mohamed
- A.M. Ngalala
- A.M. Torborg
- A.N. Kabongo
- A.N.J.D. Alberts
- A.O. Adisa
- A.O. Omigbodun
- A.O. Osinowo
- A.O. Ousseini
- A.O. Usenbo
- A.P. Gatheru
- A.P. Patience
- A.R.W. Mungherera
- A.S. Shkirban
- A.S. Singh
- A.S. Yusuf
- A.S.B. Benamour
- A.S.M. Madsen
- A.T. Robelie
- A.T.M. Masiyambiri
- A.Z. Elzoway
- A.Z. Machowski
- A.Z. Zeiton
- Abdulaziz M. Elkhogia
- Adam Hewitt-Smith
- Adams
- Ahmadou L. Samateh
- Akinyinka O. Omigbodun
- Akwasi Antwi-Kusi
- Al.-A. Amer
- Al.-J. Ahmed
- Alex M. Makupe
- Ambroise Guegni
- Amina. Kalisa
- Anatole Atomabe
- Andrew K.N. Ndonga
- Anthony R. Reed
- Apollo. Basenero
- B. Ahmed
- B. Alsellabi
- B. Chrirangi
- B. Church
- B. Dedekind
- B. Gadi
- B. Githae
- B. Kipng’etich
- B. Kiprop
- B. Lerutla
- B. Ntueba
- B. Rink
- B. Thakoor
- B. Veerasamy
- B.A. Albakosh
- B.A. Dokolwana
- B.B. Afolabi
- B.B. Osinaike
- B.B. Ryabchiy
- B.C. Businge
- B.C. Enicker
- B.E. Bilby
- B.H. Pienaar
- B.J.S. Diedericks
- B.M. Biccard
- B.M. Mabaso
- B.M. Ngari
- B.N. BN Tanjong
- B.N.K. Kaholongo
- B.O. Mofikoya
- B.O. Semo
- B.P. Thomas
- B.S. Sikombe
- B.S.G. Diale
- B.T. Amisi
- Belinda S. Kusel
- Bernard Mbwele
- Beye SeĂŻdina Alioune
- Biccard
- Biccard
- Blaise Tchaou
- Bruce M. Biccard
- Busi Mrara
- C. Bitta
- C. Chalo
- C. Changfoot
- C. Dhege
- C. Houston
- C. Kruse
- C. Lee
- C. Lionnet
- C. Manirimbere
- C. Msadabwe
- C. Nantulu
- C. Ndung’u
- C. Nnaji
- C. Ntoto
- C.A. Blake
- C.A. Roberts
- C.A.G. Smits
- C.H. Basson
- C.J. Bikuelo
- C.J.M. Mawire
- C.L.C. Lubamba
- C.M. Human
- C.M. Mwangi
- C.N. Mwaluka
- C.N. Namata
- C.R. Saaiman
- C.S. Jallow
- C.S. Sendagire
- C.S. Shambare
- C.Z. Zinyemba
- Chaibou M. Sani
- Charles Tchegnonsi
- Chris Cairns
- Christella S. Alphonsus
- Christina Salmina Gordon
- Christopher Y. Matola
- Collins
- Coulibaly Youssouf
- D. Benali
- D. Daliri
- D. Elrafifi
- D. Hugo
- D. Krick
- D. Naidoo
- D. Ndegwa
- D. Ngorora
- D. Ngouane
- D. Roytowski
- D. Tarloff
- D.E. du Plessis
- D.F. Dibwe
- D.G. Giles
- D.H. Imposo
- D.I. Uhuebor
- D.J. Van der Merwe
- D.K. Kabatoro
- D.K. Sanduku
- D.M. Adeleke
- D.M. Linyama
- D.M. Maimane
- D.M. Maluleke
- D.M. Mangoo
- D.M. Munlemvo
- D.M.A. Aurélia
- D.M.A. Randriambololona
- D.O. Ojuka
- D.P. Domoyyeri
- D.R. Bhagwandass
- D.S. Nesengani
- D.S. Sikazwe
- D.V. Manyere
- Daniel Zemenfes Ashebir
- David G. Bishop
- David Lee Skinner
- Dela A. Maiwald
- Devan. Rungan
- Diallo Gangaly
- Diango Djibo Mahamane
- Dolly M. Munlemvo
- Dominique van Dyk
- Doreen M. Mashava
- E. Atito-Narh
- E. Blignaut
- E. Chikumba
- E. Hadia
- E. Horugavye
- E. Loots
- E. Mashoko
- E. Ngatia
- E. Ninise
- E. Salaheddin
- E. Swayeb
- E.A. Alakkari
- E.A. Alzahra
- E.B. Etuk
- E.B. Holford
- E.E. Wynne
- E.F. Post
- E.K. Badianga
- E.K. Makopa
- E.M. Semenya
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- Robert D. Wise
- Rodrigue Hadecon
- Rodrigue Nascimento
- Rosalie Souhe
- Rupert M. Pearse
- S. Abdurazig
- S. Akanyun
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- Serge Mewanou
- Shaaban Nsalamba
- Simbo D. Amanor-Boadu
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- Sudha Bechan
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- T. Muzenda
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- T.M. Mwiti
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- T.P.R. Ramchurn
- T.S. Abuzalout
- T.S. Alkesa
- T.S. Mohamed
- T.S. Ngcobo
- T.S.K. Lyimo
- T.W. Munyaradzi
- T.W.A. Anabah
- Thandinkosi E. Madiba
- Theroshnie K. Kisten
- Thiam Souleymane
- Thomas Allaye
- Thuli Biyase
- Tim C. Hardcastle
- Tonya M. Esterhuizen
- Traoré Abdoulaye
- Traoré Ibrahim
- U.V. Jaganath
- Usha Singh
- Ushmaben Patel
- V. Athanse
- V. Dehal
- V. Gobin
- V. Govindasamy
- V. Makhanya
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- V. Pillay
- V. Ryndine
- V. Sinoamadi
- V.E.M. Musiba
- V.K. Kusweje
- V.K. Mushangwe
- V.L. Koller
- V.L. Moses
- V.M. Gacii
- V.M. Mtongwe
- V.M.K. Kissoon
- V.N. Nziene
- V.T. Manzini
- Veekash Gobin
- W. Abozaid
- W. Conradie
- W. Kibochi
- W. Kuhn
- W. Mathangani
- W. Njuguna
- W. Rois
- W. Sam-Awortwi
- W.A.G. Simo
- W.A.P. Ras
- W.D. Mbombo
- W.M. du Plessis
- W.M.S. Mbuyi
- W.P. Kuhn
- W.P. Makhaye
- W.V.J. Koperski
- Wong
- Y. Baitchu
- Y. Coulibaly
- Y. le Manach
- Y. Mampangula
- Y. Najm
- Y. Yakubu
- Y.A. Ali
- Y.B. Adamu
- Y.B. Bwambale
- Y.B.M. Freeman
- Y.G. Gandy
- Y.M. Yangazov
- Y.Y. Kutor
- Yannick Le Manach
- Youssouf Coulibaly
- Z. Farina
- Z. Imessaoudene
- Z. Nibe
- Z. Nyatela-Akinrinmade
- Z. Rakhda
- Z.S. Elghazal
- Z.S. Jamal
- Zipporah W.W. Ngumi
- Publication venue
- 'Elsevier BV'
- Publication date
- 17/09/2018
- Field of study
Background:
The African Surgical Outcomes Study (ASOS) showed that surgical patients in Africa have a mortality twice the global average. Existing risk assessment tools are not valid for use in this population because the pattern of risk for poor outcomes differs from high-income countries. The objective of this study was to derive and validate a simple, preoperative risk stratification tool to identify African surgical patients at risk for in-hospital postoperative mortality and severe complications.
Methods:
ASOS was a 7-day prospective cohort study of adult patients undergoing surgery in Africa. The ASOS Surgical Risk Calculator was constructed with a multivariable logistic regression model for the outcome of in-hospital mortality and severe postoperative complications. The following preoperative risk factors were entered into the model; age, sex, smoking status, ASA physical status, preoperative chronic comorbid conditions, indication for surgery, urgency, severity, and type of surgery.
Results:
The model was derived from 8799 patients from 168 African hospitals. The composite outcome of severe postoperative complications and death occurred in 423/8799 (4.8%) patients. The ASOS Surgical Risk Calculator includes the following risk factors: age, ASA physical status, indication for surgery, urgency, severity, and type of surgery. The model showed good discrimination with an area under the receiver operating characteristic curve of 0.805 and good calibration with c-statistic corrected for optimism of 0.784.
Conclusions:
This simple preoperative risk calculator could be used to identify high-risk surgical patients in African hospitals and facilitate increased postoperative surveillance.
© 2018 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.Medical Research Council of South Africa gran