A retrospective clinical study on longevity of posterior composite and amalgam restorations.

Contains fulltext : 52184.pdf (publisher's version ) (Closed access)OBJECTIVES: The purpose of this study was to evaluate retrospectively the longevity of class I and II amalgam and composite resin restorations placed in a general practice. METHODS: Patient records of a general practice were used for collecting the data for this study. From the files longevity and reasons for failure of 2867 class I and II amalgam and composite resin restorations placed in 621 patients by two operators between 1990 and 1997 were recorded in 2002. RESULTS: 912 amalgam restorations (502 by operator 1 and 410 by operator 2) and 1955 posterior composite resin restorations (1470 by operator 1 and 485 by operator 2) were placed. One hundred and eighty-two amalgam and 259 posterior composite resin restorations failed during the observation period. The main reasons for failure of the restorations were caries (34%), endodontic treatment (12%) and fracture of the tooth (13%). Life tables calculated from the data reveal a survival for composite resin of 91.7% at 5 years and 82.2% at 10 years. For amalgam the survival is 89.6% at 5 years and 79.2% at 10 years. Cox-regression analysis resulted in a significant effect of the amount of restored surfaces on the survival of the restorations. No significant effect of operator, material as well as combination of material and operator was found. SIGNIFICANCE: In the investigated general practice, two dentists obtained comparable longevity for amalgam and composite resin restorations

Longevity of repaired restorations: A practice based study.

Item does not contain fulltextThe aim was to evaluate retrospectively the influence on restoration longevity of a repair and to evaluate longevity of repaired restorations. MATERIALS AND METHODS: In a practice, 1202 amalgam and 747 composite resin restorations were placed. 407 restorations failed (amalgam 293, composite 114), 246 restorations were repaired with composite resin using an etch-and-rinse technique. Of repaired restorations reason for failure and number of surfaces of original restoration, repair date, and date of patients' last visit were recorded. Whenever a new treatment was necessary, this was considered failure. Data were analysed by Kaplan-Meier statistics and log-rank tests (p<0.05). A multi-variate Cox-regression analysis was conducted on results for variables number of surfaces, repair reason, and repaired material. RESULTS: 133 amalgam restorations (57% due to fracture) and 113 composite restorations (62% due to caries) were repaired. 151 of 246 repaired restorations (61%) were still in service without further intervention after 4.8 years. The annual failure rates for repaired amalgam and composite restorations was 9.3% and 5.7% after 4 years (log-rank, p=0.001). Restorations that were repaired due to fracture had a lower survival than restorations that were repaired due to caries (log-rank, p=0.006). The Cox-regression showed influence of the gender but no significant influence of material or reason for repair, indicating that the findings are a consequence of joint negative influences of investigated variables. CONCLUSION: The present study shows that repairs can enhance the longevity of dental restorations considerably. Moreover, repairs on restorations failing due to caries have a better prognosis compared to repairs on restorations failing due to fracture.01 oktober 201

Five-year clinical performance of posterior resin composite restorations placed by dental students.

Contains fulltext : 58422.pdf (publisher's version ) (Closed access)OBJECTIVES: To investigate the survival over a five-year period of posterior resin composite restorations placed by students. METHODS: Class I and II resin composite restorations placed by second-fourth year dental students were evaluated. Patients attended the dental school every 6 months for a regular check-up during which all restorations were checked on their clinical acceptability. In case of replacement or repair of a restoration, this was registered in the patient's record. From each record the survival time and reasons for failure of resin composite restorations were gathered. RESULTS: Seven-hundred three posterior resin composite restorations in 382 patients (49% female and 51% male, age 22-78) were evaluated. At 5 years 560 of the 703 restorations were still considered to be "clinically acceptable". Forty-nine restorations were considered as "functionally present", of which 44 were restored with a crown and four had received a new restoration adjacent to the existing restoration without its removal. Ninety-four restorations had failed. The main reasons for failure were restoration fracture, caries, endodontic treatment, defective margin and lack of proximal contact. The survival rate of the restorations was 87% at 5 years, resulting in an annual failure rate of 2.8%. CONCLUSIONS: Dental students are able to place resin composite restorations in posterior teeth with an acceptable mean annual failure rate

Seven-year clinical evaluation of painful cracked teeth restored with a direct composite restoration.

Contains fulltext : 71051.pdf (publisher's version ) (Closed access)The purpose of this study was to investigate long-term clinical effectiveness of treating painful cracked teeth with a direct bonded composite resin restoration. The hypothesis tested was that cracked teeth treated with or without cuspal coverage showed the same performance. Forty-one patients attended a dental practice with a painful cracked tooth that was restored with a direct composite resin restoration. Twenty teeth were restored without and 21 with cuspal coverage. After 7 years, 40 teeth could be evaluated. Three teeth without cuspal coverage needed an endodontic treatment, of which 2 failed as a result of fracture. No significant differences were found for tooth or pulp survival. Three more repairable restoration failures were recorded. Mean annual failure rate of restorations without cuspal coverage was 6%; no failures in restorations with cuspal coverage occurred (P = .009). A direct bonded composite resin restoration can be a successful treatment for a cracked tooth

Longevity and reasons for failure of sandwich and total-etch posterior composite resin restorations.

Item does not contain fulltex

L'économie du sport

Sport mondialisé, sport marchandisé. Le poids économique du sport. L'organisation économique du sport professionnel : le modèle fermé et collectiviste des Etats-Unis au service d'une logique de profit; le modèle ouvert et libéral en Europe au service d'une logique sportive

Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1

The estrogen receptor (ER) is an important regulator of growth and differentiation of breast epithelium. Transactivation by ER depends on a leucine-rich motif, which constitutes a ligand-regulated binding site for steroid receptor coactivators (SRCs). Cyclin D1 is frequently amplified in breast cancer and can activate ER through direct binding. We show here that cyclin D1 also interacts in a ligand-independent fashion with coactivators of the SRC-1 family through a motif that resembles the leucine-rich coactivator binding motif of nuclear receptors. By acting as a bridging factor between ER and SRCs, cyclin D1 can recruit SRC-family coactivators to ER in the absence of ligand. A cyclin D1 mutant that binds to ER but fails to recruit coactivators preferentially interferes with ER activation in breast cancer cells that have high levels of cyclin D1. These data support that cyclin D1 contributes significantly to ER activation in breast cancers in which the protein is overexpressed. Our present results reveal a novel route of coactivator recruitment to ER and establish a direct role for cyclin D1 in regulation of transcription

A study to investigate habits with tooth wear assessments among UK and non-UK dental practitioners

Contains fulltext : 220473.pdf (Publisher’s version ) (Closed access)Aim To assess the habits of tooth wear risk assessment and charting using a tooth wear index, by UK and non-UK dental practitioners.Design A questionnaire-based evaluation.Methods Three hundred and two completed questionnaires were returned and the outcomes analysed using descriptives, Chi-squared test and Fisher's exact test in SPSS. Significance was inferred at p <0.05.Results Based on a sample of 297 responses, 81% agreed to the need to undertake risk assessment for all dental patients attending for a first-time consultation. Fifty-nine percent undertook risk assessments for 'new patients' previously identified with signs of severe tooth wear. The routine use of a clinical index to perform tooth wear charting was described by 13.5%, with 5% documenting the frequent use of the BEWE tool. While specialist dental practitioners or those with further post-graduate training were more likely to use a tooth wear index (p <0.05), there were no other significant relationships between any of the variables in the sample and the practising habits assessed.Conclusion This investigation alludes to good levels of professional awareness of tooth wear. However, the need for improvement with the actual undertaking of risk assessments for tooth wear and consistency with tooth wear assessment and charting was determined. The need for appropriate professional guidance for the undertaking of tooth wear assessments is supported by the outcomes of this investigation