50 research outputs found
Ocurrencia de la enfermedad Hoja de malvon en zonas vitÃcolas de Catamarca y La Rioja, Argentina
PosterLa ‘hoja de malvón’ (HM) es la principal enfermedad de la madera de la vid detectada en el paÃs, en plantas adultas y diferentes variedades. Está asociada a especies de la familia Botryosphaeriaceae, Phaeoacremonium spp., Arambarria destruens y Phaeomoniella chlamydospora. En Catamarca y La Rioja, reviste un problema importante dada la elevada superficie de viñedos adultos con variedades susceptibles. El trabajo busca (i) determinar la incidencia y la severidad de la enfermedad y (ii) correlacionar sÃntomas aéreos, lesiones en madera y especies fúngicas aisladas. Durante el periodo 2019-2021, se prospectaron viñedos afectados y se extrajeron muestras de madera de plantas adultas sintomáticas. Las muestras fueron desinfectadas en hipoclorito de sodio al 2%, enjuagas en ADE y desinfectadas con alcohol 70°. Pequeñas porciones de madera de la zona de transición se sembraron en medio APG. Las cepas fúngicas obtenidas fueron diferenciadas por caracteres macro y micromorfólogicos y se utilizaron claves taxonómicas para aproximar al estado de género. En ambas provincias, la HM está presente en las zonas vitÃcolas, con elevada incidencia (85%) y severidad (75%) para las variedades Cabernet Sauvignon, Torrontés riojano y Malbec. Se identificaron cinco tipos de lesiones en madera (necrosis marginal, radial, central, puntuaciones negras y pudrición blanda) asociadas al mismo complejo de sÃntomas en la parte aérea. Lasiodiplodia spp., Botryosphaeria spp., y Phaeoacremonium spp., estuvieron relacionados a las necrosis, Phaeomoniella chlamydospora a las puntuaciones y Phaeoacremonium spp., a la pudrición blanda. Los resultados obtenidos aportan al conocimiento del patosistema HM.EEA CatamarcaFil: Carrasco, Franca Denise. Instituto Nacional de TecnologÃa Agropecuaria (INTA). Estación Experimental Agropecuaria Catamarca; ArgentinaFil: Oviedo, Hector Javier. Instituto Nacional de TecnologÃa Agropecuaria (INTA). Estación Experimental Agropecuaria Catamarca; ArgentinaFil: Gonzalez Ribot, Joaquin Victor. Instituto Nacional de TecnologÃa Agropecuaria (INTA). Estación Experimental Agropecuaria Chilecito; ArgentinaFil: Sosa, Pablo Antonio. Instituto Nacional de TecnologÃa Agropecuaria (INTA). Estación Experimental Agropecuaria Catamarca; ArgentinaFil: Sosa, Flavio Isaac. Instituto Nacional de TecnologÃa Agropecuaria (INTA). Estación Experimental Agropecuaria Catamarca; ArgentinaFil: Maza, Claudia Elizabeth. Instituto Nacional de TecnologÃa Agropecuaria (INTA). Estación Experimental Agropecuaria Chilecito; ArgentinaFil: Bustos, E. Universidad Nacional de Catamarca. Facultad de Ciencias Agrarias; ArgentinaFil: Longone, Maria Valeria. Instituto Nacional de TecnologÃa Agropecuaria (INTA). Estación Experimental Agropecuaria Mendoza; ArgentinaFil: Escoriaza, Maria Georgina. Instituto Nacional de TecnologÃa Agropecuaria (INTA). Estación Experimental Agropecuaria Mendoza; Argentin
Unusually high pch coupling constants in cyclopropenylphosphonium salts
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/33248/1/0000639.pd
Neurosteroid and neurotransmitter alterations in Parkinson's disease
Parkinson's disease (PD) is associated with a massive loss of dopaminergic cells in the substantia nigra leading to dopamine hypofunction and alteration of the basal ganglia circuitry. These neurons, are under the control, among others, of the excitatory glutamatergic and inhibitory γ-aminobutyric acid (GABA) systems. An imbalance between these systems may contribute to excitotoxicity and dopaminergic cell death. Neurosteroids, a group of steroid hormones synthesized in the brain, modulate the function of several neurotransmitter systems. The substantia nigra of the human brain expresses high concentrations of allopregnanolone (3α, 5αtetrahydroprogesterone), a neurosteroid that positively modulates the action of GABA at GABAA receptors and of 5α-dihydroprogesterone, a neurosteroid acting at the genomic level. This article reviews the roles of NS acting as neuroprotectants and as GABAA receptor agonists in the physiology and pathophysiology of the basal ganglia, their impact on dopaminergic cell activity and survival, and potential therapeutic application in PD
Cerebrospinal fluid from frontotemporal dementia patients is toxic to neurons
Frontotemporal Lobar Degeneration (FTD) is a neurodegenerative disease characterized by a progressive deterioration of cognitive functions. Currently, no effective treatment exists. We have studied cytotoxicity and neuronal functionality in cortical and spinal cord cultures upon exposure to cerebrospinal fluid (CSF) from 39 FTD patients. FTD-CSF alters the miniature excitatory postsynaptic currents in the cortical cultures and it is toxic to spinal cord cultures, particularly to GABAergic+ and calbindin-D28k + neurons
Lithium does protect in amyotrophic lateral sclerosis: results on human patients and mechanism involved in transgenic mice.
The complex roles of neurosteroids in depression and anxiety disorders.
The role of neurosteroids in neuropsychiatric disorders has been thoroughly investigated in many research studies that have stressed their significant pathophysiological function in neuropsychiatry. In this review, we will focus mainly on the steroids active on the GABA(A) receptors studied in anxiety and depression. The aim is to discuss the controversial results reported in research on anxiety and depressive disorders. We suggest the combined use of biological parameters linked to psychopathological dimensions to make more homogeneous diagnoses and to develop more precise therapies for the treatment of depression and anxiety disorders. We discuss the role of neurosteroids in the pathophysiology and therapy of anxiety and depression. Finally, we consider the possibility of using quantification of mRNA expression of steroidogenic enzymes from peripheral sources in neuropsychiatry