"It's All COVID's Fault!": Symptoms of Distress among Workers in an Italian General Hospital during the Pandemic

Background: Since the outbreak of the COVID-19 pandemic, healthcare workers (HCWs) have been faced with specific stressors endangering their physical and mental health and their functioning. This study aimed to assess the short-term psychological health of a sample of Italian HCWs and the related influencing factors. In particular, the study focused on the differences related to HCWs' gender and to having been directly in charge of COVID-19 patients or not. Methods: An online survey was administered to the whole staff of the Modena General University Hospital three months after the onset of the pandemic, in 2020. Demographic data and changes in working and living conditions related to COVID-19 were collected; mental health status was assessed by the Depression, Anxiety and Stress Scale (DASS-21) and the Impact of Event Scale-Revised (IES-R). Results: 1172 out of 4788 members returned the survey (response rate = 24.5%), the male/female ratio was 30/70%. Clinically significant symptoms assessed according to the DASS-21 emerged among 21.0% of the respondents for depression, 22.5% for anxiety and 27.0% for stress. Symptoms suggestive of a traumatic reaction were reported by 19.0% of the sample. Symptoms of psychological distress were statistically associated with female gender, job role, ward, changes in lifestyle, whereas first-line work with COVID-19 patients was statistically associated with more stress symptoms. HCWs reported a significant level of psychological distress that could reach severe clinical significance and impact dramatically their quality of life and functioning. Conclusions: Considering the persistence of the international emergency, effective strategies to anticipate, recognize and address distress in HCWs are essential, also because they may impact the organization and effectiveness of healthcare systems

An update on Current Clinical Management of Eating Disorders.

This paper aims to review the most updated literarature on the clinical management of Eating Disorders

Discrete monitoring of chemical parameters in ground waters of Mt. Etna volcano: 2000–2006

Three sites of groundwater captation on Mt. Etna volcano (namely Currone, Ilice and Pavone) were sampled systematically for six years (from2000 to 2006) for the determination of the major ionic composition of water. The monitored siteswere chosen among those most representative of the geochemical characteristics of the groundwater systems of the volcano. The period studied was characterized by several strong eruptions of Mt. Etna, both at its summit craters and along its flanks. The overall composition of the waters sampled at Currone and Ilice falls in the group of bicarbonate-alkaline-earth compositions, whereas those from Pavone show a bicarbonate- alkaline composition. In all sites, however, some samples show input of chlorine-sulfate alkaline waters, likely due to interaction between fresh groundwater and either acidic waters from SO2-polluted rainwater, (more evident at Pavone) or geothermal brines (more evident at Currone). Significant temporal variations affected, in a more or less marked way, all of the parameters measured at the three sites. Basic statistical correlations among the parameters at each site allowed to discover a general coherent temporal behavior of all major ions dissolved in Mt. Etna's ground waters. Factor Analysis allowed showing up to three main groups of parameters with similar temporal behavior, depending on the site. A first group was explained by interaction between volcanic groundwaters and geothermal fluids; a second groupwas related with leaching of the host volcanic rocks by CO2-rich volcanicwater; a third groupwas explained as due to input of plume-SO2-derived sulfate through water recharge. Using normal probability plots for each parameter at the three sites it was possible to reveal different geochemical populations explained as background, anomalous values and, possibly, outliers. Plotting the temporal patterns of all the monitored parameters versus the concurrent eruptive episodes at Mt. Etna, we discovered significant correlations that, although with different intensity and rate depending on the parameter and on the site, highlighted several geochemical processes induced by interaction between cold groundwater and magmatic/hydrothermal fluids, mostly following changes in the ground permeability of the volcanic pile. These processes seemed to be enhanced during periods of shallow magma accumulation inside of the volcano that preceded summit or flank eruptions occurred at Mt. Etna during the monitored period.Published273-2871VV. AltroJCR Journa

Chloro-1,4-dimethyl-9H-carbazole derivatives displaying anti-HIV activity

Despite the progress achieved by anti-retroviral drug research in the last decades, the discovery of novel compounds endowed with selective antiviral activity and reduced side effects is still a necessity. At present, the most urgent requirement includes the improvement of HIV (Human Immunodeficiency Virus) prevention and sexual transmission and the development of new drugs to treat the chronic lifelong infection.status: publishe

Chloro-1,4-dimethyl-9H-carbazole derivatives displaying anti-HIV activity

Background: Despite the progress achieved by anti-retroviral drug research in the last decades, the discovery of novel compounds endowed with selective antiviral activity and reduced side effects is still a necessity. At present, the most urgent requirement includes the improvement of HIV (Human Immunodeficiency Virus) prevention and sexual transmission and the development of new drugs to treat the chronic lifelong infection. Methods: Six chloro-1,4-dimethyl-9H-carbazoles (2a,b–4a,b) have been prepared following opportunely modified known chemical procedures and tested in luciferase and Escherichia coli β-galactosidase expressing CD4+, CXCR4+, CCR5+ TZM-bl cells. Results and Conclusion: a preliminary biological investigation on the synthesized small series of chloro-1,4-dimethyl-9H-carbazoles has been carried out. Among all tested compounds, a nitro-derivative (3b) showed the most interesting profile representing a suitable lead for the development of novel anti-HIV drugs

Carbazole derivatives as kinase-targeting inhibitors for cancer treatment

Protein Kinases (PKs) are a heterogeneous family of enzymes that modulate several biological pathways, including cell division, cytoskeletal rearrangement, differentiation and apoptosis. In particular, due to their crucial role during human tumorigenesis and cancer progression, PKs are ideal targets for the design and development of effective and low toxic chemotherapeutics and represent the second group of drug targets after G-protein-coupled receptors.Nowadays, several compounds have been claimed to be PKs inhibitors, and some of them, such as imatinib, erlotinib and gefitinib, have already been approved for clinical use, whereas more than 30 others are in the various phases of clinical trials. Among them, some natural or synthetic carbazole-based molecules represent promising PKs inhibitors due to their capability to interfere with PK activity by different mechanisms of action including the ability to act as DNA intercalating agents, interfere with the activity of enzymes involved in DNA duplication, such as topoisomerases and telomerases, and inhibit other proteins such as cyclin-dipendent kinases or antagonize estrogen receptors. Thus, carbazoles can be considered a promising class of compounds to be adopted in targeted therapy of different types of cancer

Carbazole derivatives as kinase-targeting inhibitors for cancer treatment

Protein Kinases (PKs) are a heterogeneous family of enzymes that modulate several biological pathways, including cell division, cytoskeletal rearrangement, differentiation and apoptosis. In particular, due to their crucial role during human tumorigenesis and cancer progression, PKs are ideal targets for the design and development of effective and low toxic chemotherapeutics and represent the second group of drug targets after G-protein-coupled receptors. Nowadays, several compounds have been claimed to be PKs inhibitors, and some of them, such as imatinib, erlotinib and gefitinib, have already been approved for clinical use, whereas more than 30 others are in the various phases of clinical trials. Among them, some natural or synthetic carbazole-based molecules represent promising PKs inhibitors due to their capability to interfere with PK activity by different mechanisms of action including the ability to act as DNA intercalating agents, interfere with the activity of enzymes involved in DNA duplication, such as topoisomerases and telomerases, inhibit other proteins such as cyclin-dependent kinases or antagonize estrogen receptors. Thus carbazoles can be considered a promising this class of compounds to be adopted in targeted therapy of different types of cancer

The Cherenkov Telescope Array transient and multi-messenger program

The Cherenkov Telescope Array (CTA) is a next generation ground-based very-high-energy gamma-ray observatory that will allow for observations in the >10 GeV range with unprecedented photon statistics and sensitivity. This will enable the investigation of the yet-marginally explored physics of short-time-scale transient events. CTA will thus become an invaluable instrument for the study of the physics of the most extreme and violent objects and their interactions with the surrounding environment. The CTA Transient program includes follow-up observations of a wide range of multi-wavelength and multi-messenger alerts, ranging from compact galactic binary systems to extragalactic events such as gamma-ray bursts (GRBs), core-collapse supernovae and bright AGN flares. In recent years, the first firm detection of GRBs by current Cherenkov telescope collaborations, the proven connection between gravitational waves and short GRBs, as well as the possible neutrino-blazar association with TXS 0506+056 have shown the importance of coordinated follow-up observations triggered by these different cosmic signals in the framework of the birth of multi-messenger astrophysics. In the next years, CTA will play a major role in these types of observations by taking advantage of its fast slewing (especially for the CTA Large Size Telescopes), large effective area and good sensitivity, opening new opportunities for time-domain astrophysics in an energy range not affected by selective absorption processes typical of other wavelengths. In this contribution we highlight the common approach adopted by the CTA Transients physics working group to perform the study of transient sources in the very-high-energy regime

Searching for very-high-energy electromagnetic counterparts to gravitational-wave events with the Cherenkov Telescope Array

The detection of electromagnetic (EM) emission following the gravitational wave (GW) event GW170817 opened the era of multi-messenger astronomy with GWs and provided the first direct evidence that at least a fraction of binary neutron star (BNS) mergers are progenitors of short Gamma-Ray Bursts (GRBs). GRBs are also expected to emit very-high energy (VHE, > 100 GeV) photons, as proven by the recent MAGIC and H.E.S.S. observations. One of the challenges for future multi-messenger observations will be the detection of such VHE emission from GRBs in association with GWs. In the next years, the Cherenkov Telescope Array (CTA) will be a key instrument for the EM follow-up of GW events in the VHE range, owing to its unprecedented sensitivity, rapid response, and capability to monitor a large sky area via scan-mode operation. We present the CTA GW follow-up program, with a focus on the searches for short GRBs possibly associated with BNS mergers. We investigate the possible observational strategies and we outline the prospects for the detection of VHE EM counterparts to transient GW events