Linking Stochastic Dynamics to Population Distribution: An Analytical Framework of Gene Expression

We present an analytical framework describing the steady-state distribution of protein concentration in live cells, considering that protein production occurs in random bursts with an exponentially distributed number of molecules. We extend this framework for cases of transcription autoregulation and noise propagation in a simple genetic network. This model allows for the extraction of kinetic parameters of gene expression from steady-state distributions of protein concentration in a cell population, which are available from single cell data obtained by flow cytometry or fluorescence microscopy

Radiative Neutrino Mass with Z3Z_3 Dark matter: From Relic Density to LHC Signatures

In this work we give a comprehensive analysis on the phenomenology of a specific $\mathbb{Z}_3$ dark matter (DM) model in which neutrino mass is induced at two loops by interactions with a DM particle that can be a complex scalar or a Dirac fermion. Both the DM properties in relic density and direct detection and the LHC signatures are examined in great detail, and indirect detection for gamma-ray excess from the Galactic Center is also discussed briefly. On the DM side, both semi-annihilation and co-annihilation processes play a crucial role in alleviating the tension of parameter space between relic density and direct detection. On the collider side, new decay channels resulting from $\mathbb{Z}_3$ particles lead to distinct signals at LHC. Currently the trilepton signal is expected to give the most stringent bound for both scalar and fermion DM candidates, and the signatures of fermion DM are very similar to those of electroweakinos in simplified supersymmetric models.Comment: 40 pages, 24 figure

Research progress on the relationship between testosterone and cardiovascular disease

Testosterone is the main androgen in human body and has many important effects on cardiovascular system Testosterone deficiency is common in patients with cardiovascular diseases. Many data suggest that low serum testosterone level is related to cardiovascular diseases such as coronary heart disease, heart failure and arrhythmiahowever, the mechanism involved is not completely clearin recent years, the research on testosterone and cardiovascular diseases has attracted much attention. This paper summarizes the pathogenesis and influence of testosterone related cardiovascular diseases

Systematic Scatterometer Wind Errors Near Coastal Mountains.

Satellite scatterometers provide the only regular observations of surface wind vectors over vast swaths of the world oceans, including coastal regions, which are of great scientific and societal interest but still present challenges for remote sensing. Here we demonstrate systematic scatterometer wind errors near Hawaii's Big Island: Two counter-rotating lee vortices, which are clear in the International Comprehensive Ocean-Atmosphere Data Set ship-based wind climatology and in aircraft observations, are absent in the Jet Propulsion Laboratory and Remote Sensing Systems scatterometer wind climatologies. We demonstrate similar errors in the representation of transient Catalina Eddy events in the Southern California Bight. These errors likely arise from the nonuniqueness of scatterometer wind observations, that is, an "ambiguity removal" is required during processing to select from multiple wind solutions to the geophysical model function. We discuss strategies to improve the ambiguity selection near coastal mountains, where small-scale wind reversals are common

Evolution of interactions and cooperation in the spatial prisoner's dilemma game

We study the evolution of cooperation in the spatial prisoner's dilemma game where players are allowed to establish new interactions with others. By employing a simple coevolutionary rule entailing only two crucial parameters, we find that different selection criteria for the new interaction partners as well as their number vitally affect the outcome of the game. The resolution of the social dilemma is most probable if the selection favors more successful players and if their maximally attainable number is restricted. While the preferential selection of the best players promotes cooperation irrespective of game parametrization, the optimal number of new interactions depends somewhat on the temptation to defect. Our findings reveal that the "making of new friends" may be an important activity for the successful evolution of cooperation, but also that partners must be selected carefully and their number limited.Comment: 14 pages, 6 figures; accepted for publication in PLoS ON