Oncologic Emergencies: Immune-Based Cancer Therapies and Complications

Cancer therapies have undergone several recent advancements. Current cancer treatments include immune-based therapies comprised of checkpoint inhibitors, and adoptive immunotherapy; each treatment has the potential for complications that differ from chemotherapy and radiation. This review evaluates immune-based therapies and their complications for emergency clinicians. Therapy complications include immune-related adverse events (irAE), cytokine release syndrome (CRS), autoimmune toxicity, and chimeric antigen receptor (CAR) T-cell-related encephalopathy syndrome (CRES). Immune-related adverse events are most commonly encountered with checkpoint inhibitors and include dermatologic complications, pneumonitis, colitis/diarrhea, hepatitis, and endocrinopathies. Less common irAEs include nephritis, myocardial injury, neurologic toxicity, ocular diseases, and musculoskeletal complications. CRS and CRES are more commonly associated with CAR T-cell therapy. CRS commonly presents with flu-like illness and symptoms resembling sepsis, but severe myocardial and pulmonary disease may occur. Critically ill patients require resuscitation, broad-spectrum antibiotics, and hematology/oncology consultation

Immortality in Empedocles

Most of the work for the paper was undertaken in Toronto during a Leverhulme Research Fellowship.The paper examines Empedocles’ attributions of immortality. I argue that Empedocles does not withhold immortality from the gods but rather has an unorthodox conception of what immortality is. Immortality does not mean, or imply, endless duration. A god’s immortality is its continuity, as one and the same organism, over a long but finite period. This conception of divine immortality then influences Empedocles’ other attributions of immortality, each of which marks a contrast with discontinuity, real or apparent. The nature of this contrast varies from context to context, and there is considerable heterogeneity in the list of immortal items. On the other hand, the attribution of immortality never implies that the item is completely changeless.Publisher PDFPeer reviewe

The sophists’ detractors and Plato’s representation of Socrates

In several dialogues Socrates criticizes negative comments made against a sophist or the sophists. I show that Socrates’ target really is the sophists’ detractor, not the sophists themselves. From these passages I draw two broader conclusions. First, Plato’s defence of Socrates’ memory sometimes relies on creating a parallel between sophists and Socrates, rather than distinguishing between them and him. Secondly, Socratic philosophical practice has a widely neglected feature: examining and correcting the criticism made by his interlocutors against others.Publisher PDFPeer reviewe

The goodness of the virtues and the Sun-like good

Does the Longer Way, described but not taken in Plato's Republic, provide understanding that justice and other virtues are good? Sarah Broadie argues that it does not, on the grounds that Socrates and the brothers learn about justice's goodness without taking the Longer Way. I argue that Socrates’ arguments for justice's goodness are not so complete as to make it impossible for philosopher-rulers to gain from the Longer Way greater understanding of the same point. My main textual evidence is a passage of Book IX (589b–c), a summary that has been widely underappreciated.Publisher PDFPeer reviewe

Relay-proof channels using UWB lasers

Alice is a hand-held device. Bob is a device providing a service, such as an ATM, an automatic door, or an anti-aircraft gun pointing at the gyro-copter in which Alice is travelling. Bob and Alice have never met, but share a key, which Alice uses to request a service from Bob (dispense cash, open door, don't shoot). Mort pretends to Bob that she is Alice, and her accomplice Cove pretends to Alice that he is Bob. Mort and Cove relay the appropriate challenges and responses to one another over a channel hidden from Alice and Bob. Meanwhile Alice waits impatiently in front of a different ATM, or the wrong door, or another gun. How can such an attack be prevented?Final Accepted Versio

[Insert Song Lyrics Here]: The Uses and Misuses of Popular Music Lyrics in Legal Writing

Legal writers frequently utilize the lyrics of popular music artists to help advance a particular theme or argument in legal writing. And if the music we listen to says something about us as individuals, then the music we, the legal profession as a whole, write about may something about who we are as a profession. A study of citations to popular artists in law journals reveals that, not surprisingly, Bob Dylan is the most popular artist in legal scholarship. The list of names of the other artists rounding out the Top Ten essentially reads like a Who’s Who of baby boomer favorites. Often, attorneys use the lyrics of popular music in fairly predictable ways in their writing, sometimes with adverse impact on the persuasiveness of the argument they are advancing. However, if one digs deeper, one can find numerous instances in which legal writers incorporate the lyrics of popular music into their writing in more creative ways

Whistleblowing Attorneys and Ethical Infrastructures

Rule 5.1 of the ABA’s Model Rules of Professional Conduct requires law firm partners to make reasonable efforts to supervise subordinate attorneys and to ensure that the firm has internal measures in place that give \u27reasonable assurance\u27 that all lawyers within the firm are complying with their ethical obligations. Despite the existence of this ethical duty, there are enough judicial decisions involving attorneys who have been fired for blowing the whistle on unethical conduct to lead one to suspect that perhaps law firm compliance measures regarding Rule 5.1 leave something to be desired. This Article discusses the role that a law firm’s ethical infrastructure - or lack thereof - may have on encouraging junior attorneys to make internal and external reports of suspected unethical conduct. It describes the results of a survey concerning law firm compliance measures and offers several proposals to encourage attorneys to make internal reports of suspected unethical conduct and to protect those attorneys who make internal and external reports of suspected unethical conduct