2,173 research outputs found
DNA Targeting as a Likely Mechanism Underlying the Antibacterial Activity of Synthetic Bis-Indole Antibiotics
We previously reported the synthesis and biological activity of a series of cationic bis-indoles with potent, broad-spectrum antibacterial properties. Here, we describe mechanism of action studies to test the hypothesis that these compounds bind to DNA and that this target plays an important role in their antibacterial outcome. The results reported here indicate that the bis-indoles bind selectively to DNA at A/T-rich sites, which is correlated with the inhibition of DNA and RNA synthesis in representative Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) organisms. Further, exposure of E. coli and S. aureus to representative bis-indoles resulted in induction of the DNA damage-inducible SOS response. In addition, the bis-indoles were found to be potent inhibitors of cell wall biosynthesis; however, they do not induce the cell wall stress stimulon in S. aureus, suggesting that this pathway is inhibited by an indirect mechanism. In light of these findings, the most likely basis for the observed activities of these compounds is their ability to bind to the minor groove of DNA, resulting in the inhibition of DNA and RNA synthesis and other secondary effects
SDSSJ103913.70+533029.7: A Super Star Cluster in the Outskirts of a Galaxy Merger
We describe the serendipitous discovery in the spectroscopic data of the
Sloan Digital Sky Survey of a star-like object, SDSSJ103913.70+533029.7, at a
heliocentric radial velocity of +1012 km/s. Its proximity in position and
velocity to the spiral galaxy NGC 3310 suggests an association with the galaxy.
At this distance, SDSSJ103913.70+533029.7 has the luminosity of a super star
cluster and a projected distance of 17 kpc from NGC 3310. Its spectroscopic and
photometric properties imply a mass of > 10^6 solar masses and an age close to
that of the tidal shells seen around NGC 3310, suggesting that it formed in the
event which formed the shells.Comment: Accepted by AJ: 4 figures (1 color
A Lyman-alpha-only AGN from the Sloan Digital Sky Survey
The Sloan Digital Sky Survey has discovered a z=2.4917 radio-loud active
galactic nucleus (AGN) with a luminous, variable, low-polarization UV
continuum, H I two-photon emission, and a moderately broad Lyman-alpha line
(FWHM = 1430 km/s) but without obvious metal-line emission. SDSS
J113658.36+024220.1 does have associated metal-line absorption in three
distinct, narrow systems spanning a velocity range of 2710 km/s. Despite
certain spectral similarities, SDSS J1136+0242 is not a Lyman-break galaxy.
Instead, the Ly-alpha and two-photon emission can be attributed to an extended,
low-metallicity narrow-line region. The unpolarized continuum argues that we
see SDSS J1136+0242 very close to the axis of any ionization cone present. We
can conceive of two plausible explanations for why we see a strong UV continuum
but no broad-line emission in this `face-on radio galaxy' model for SDSS
J1136+0242: the continuum could be relativistically beamed synchrotron emission
which swamps the broad-line emission; or, more likely, SDSS J1136+0242 could be
similar to PG 1407+265, a quasar in which for some unknown reason the
high-ionization emission lines are very broad, very weak, and highly
blueshifted.Comment: AJ, in press, 10 pages emulateapj forma
Improved Dynamical Masses for Six Brown Dwarf Companions Using Hipparcos and Gaia EDR3
We present comprehensive orbital analyses and dynamical masses for the
substellar companions Gl~229~B, Gl~758~B, HD~13724~B, HD~19467~B, HD~33632~Ab,
and HD~72946~B. Our dynamical fits incorporate radial velocities, relative
astrometry, and most importantly calibrated Hipparcos-Gaia EDR3 accelerations.
For HD~33632~A and HD~72946 we perform three-body fits that account for their
outer stellar companions. We present new relative astrometry of Gl~229~B with
Keck/NIRC2, extending its observed baseline to 25 years. We obtain a 1\%
mass measurement of for the first T dwarf Gl~229~B
and a 1.2\% mass measurement of its host star ()
that agrees with the high-mass-end of the M dwarf mass-luminosity relation. We
perform a homogeneous analysis of the host stars' ages and use them, along with
the companions' measured masses and luminosities, to test substellar
evolutionary models. Gl~229~B is the most discrepant, as models predict that an
object this massive cannot cool to such a low luminosity within a Hubble time,
implying that it may be an unresolved binary. The other companions are
generally consistent with models, except for HD~13724~B that has a host-star
activity age 3.8 older than its substellar cooling age. Examining our
results in context with other mass-age-luminosity benchmarks, we find no trend
with spectral type but instead note that younger or lower-mass brown dwarfs are
over-luminous compared to models, while older or higher-mass brown dwarfs are
under-luminous. The presented mass measurements for some companions are so
precise that the stellar host ages, not the masses, limit the analysis.Comment: Accepted for publication in AJ. References updated in version 2. See
the journal version for the full quality figures. Figure sets and the MCMC
chains (reduced to just 1000 samples however) are included with the journal
version of the article, and pre-publication at
https://drive.google.com/drive/folders/1_A8QYn9NyPgmGqJaY5sMHyT_wAS3uRRK?usp=sharin
The Lantern Vol. 51, No. 1, Fall 1984
• Sky Eyes • Flowerwait • Haiku • Sunwatch • Epitaph of A Tale • How Do You Tell A Child • Vineyard Wind • By The Sea • The Wanderer • In Back of the Real Supermarket in Collegeville • Mitosis • Smoke Dreams • On Humankind Today - A Message • Dragon • The Lull • Finale • The Sun • Three Steps in Life • Seaside • To Mark • To Father • Yesterday - Today • The Stars • The Journey • Our Shared Experience, Miles Away • Coming Home • Blossom • Life is the Teacher • Midnight Stroll in February • Eyes (Karen\u27s Poem) • Your Love • Same Welcome as Odysseus • Europa • Sinn Fein • Idle Dreams • I Can Take A Hint • In Retrospect • Rest • China and Porcelain are One in the Same • Momenthttps://digitalcommons.ursinus.edu/lantern/1125/thumbnail.jp
The Sloan Digital Sky Survey Quasar Catalog I. Early Data Release
We present the first edition of the Sloan Digital Sky Survey (SDSS) Quasar
Catalog. The catalog consists of the 3814 objects (3000 discovered by the SDSS)
in the initial SDSS public data release that have at least one emission line
with a full width at half maximum larger than 1000 km/s, luminosities brighter
than M_i^* = -23, and highly reliable redshifts. The area covered by the
catalog is 494 square degrees; the majority of the objects were found in SDSS
commissioning data using a multicolor selection technique. The quasar redshifts
range from 0.15 to 5.03. For each object the catalog presents positions
accurate to better than 0.2" rms per coordinate, five band (ugriz) CCD-based
photometry with typical accuracy of 0.05 mag, radio and X-ray emission
properties, and information on the morphology and selection method. Calibrated
spectra of all objects in the catalog, covering the wavelength region 3800 to
9200 Angstroms at a spectral resolution of 1800-2100, are also available. Since
the quasars were selected during the commissioning period, a time when the
quasar selection algorithm was undergoing frequent revisions, the sample is not
homogeneous and is not intended for statistical analysis.Comment: 27 pages, 4 figures, 4 tables, accepted by A
Colors of 2625 Quasars at 0<z<5 Measured in the Sloan Digital Sky Survey Photometric System
We present an empirical investigation of the colors of quasars in the Sloan
Digital Sky Survey (SDSS) photometric system. The sample studied includes 2625
quasars with SDSS photometry. The quasars are distributed in a 2.5 degree wide
stripe centered on the Celestial Equator covering square degrees.
Positions and SDSS magnitudes are given for the 898 quasars known prior to SDSS
spectroscopic commissioning. New SDSS quasars represent an increase of over
200% in the number of known quasars in this area of the sky. The ensemble
average of the observed colors of quasars in the SDSS passbands are well
represented by a power-law continuum with (). However, the contributions of the bump
and other strong emission lines have a significant effect upon the colors. The
color-redshift relation exhibits considerable structure, which may be of use in
determining photometric redshifts for quasars. The range of colors can be
accounted for by a range in the optical spectral index with a distribution
(95% confidence), but there is a red tail in the
distribution. This tail may be a sign of internal reddening. Finally, we show
that there is a continuum of properties between quasars and Seyfert galaxies
and we test the validity of the traditional division between the two classes of
AGN.Comment: 66 pages, 15 figures (3 color), accepted by A
The Milky Way Tomography With SDSS. III. Stellar Kinematics
We study Milky Way kinematics using a sample of 18.8 million main-sequence stars with r 20 degrees). We find that in the region defined by 1 kpc < Z < 5 kpc and 3 kpc < R < 13 kpc, the rotational velocity for disk stars smoothly decreases, and all three components of the velocity dispersion increase, with distance from the Galactic plane. In contrast, the velocity ellipsoid for halo stars is aligned with a spherical coordinate system and appears to be spatially invariant within the probed volume. The velocity distribution of nearby (Z < 1 kpc) K/M stars is complex, and cannot be described by a standard Schwarzschild ellipsoid. For stars in a distance-limited subsample of stars (< 100 pc), we detect a multi-modal velocity distribution consistent with that seen by HIPPARCOS. This strong non-Gaussianity significantly affects the measurements of the velocity-ellipsoid tilt and vertex deviation when using the Schwarzschild approximation. We develop and test a simple descriptive model for the overall kinematic behavior that captures these features over most of the probed volume, and can be used to search for substructure in kinematic and metallicity space. We use this model to predict further improvements in kinematic mapping of the Galaxy expected from Gaia and the Large Synoptic Survey Telescope.NSF AST-615991, AST-0707901, AST-0551161, AST-02-38683, AST-06-07634, AST-0807444, PHY05-51164NASA NAG5-13057, NAG5-13147, NNXO-8AH83GPhysics Frontier Center/Joint Institute for Nuclear Astrophysics (JINA) PHY 08-22648U.S. National Science FoundationMarie Curie Research Training Network ELSA (European Leadership in Space Astrometry) MRTN-CT-2006-033481Fermi Research Alliance, LLC, United States Department of Energy DE-AC02-07CH11359Alfred P. Sloan FoundationParticipating InstitutionsJapanese MonbukagakushoMax Planck SocietyHigher Education Funding Council for EnglandMcDonald Observator
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