Sodium-glucose cotransporter-2 inhibitors and cancer outcomes: A systematic review and meta-analysis of randomized controlled trials

•Data on malignancy risk with SGLT2 inhibitors is conflicting.•The effect of SGLT2 inhibitors on cancer mortality is unknown.•Meta-analysis to evaluate cancer outcomes with SGLT2 inhibitor treatment in adults.•Pooled data of 116,365 participants showed no increse in risk of cancer outcomes.•TSA showed that the sample size was sufficient to avoid missing alternative results. Concerns regarding breast and bladder cancer risk with Sodium-glucose cotransporter-2 (SGLT2) inhibitors remain controversial and its effect on cancer mortality is unknown. We aim to evaluate the association between SGLT2 inhibitors and the risk of cancer outcomes. We searched PubMed, Embase and CENTRAL up to June 20th, 2022, for randomized controlled trials of SGLT2 inhibitors in adults, with a minimum follow-up of 48 weeks. Researchers extracted study-level data and assessed within-study risk of bias with the RoB 2.0 tool and quality of evidence with GRADE. We performed meta-analyses summarizing the relative risks (RRs) of cancer outcomes. Seventy-six trials encompassing 116,375 participants were selected. Overall risk of bias was low. SGLT2 inhibitors did not reduce/increase the overall risk of cancer (RR, 1.03; 95% confidence interval [CI], 0.96–1.10) and cancer mortality (RR, 0.99; 95% CI, 0.85–1.16). SGLT2 inhibitors likely result in little to no difference in the risk of breast (RR, 1.01; 95% CI 0.77–1.32) and bladder cancers (RR, 0.93; 95% CI 0.71–1.21). Trial sequential analysis provided evidence that the sample size was sufficient to avoid missing alternative results. SGLT2 inhibitors are not associated with an increased risk of cancer outcomes, providing reassuring data regarding previous safety concerns

RA Differentiation Enhances Dopaminergic Features, Changes Redox Parameters, and Increases Dopamine Transporter Dependency in 6-Hydroxydopamine-Induced Neurotoxicity in SH-SY5Y Cells

Experimental investigations were performed to characterize the mechanical properties of bamboo fiber-polyester composites. The composite laminates were fabricated by infusing different forms of untreated bamboo fibers (randomly oriented, bamboo textiles and bamboo foam cores) with polyester resin. The results showed that the engineered bamboo fiber composites have strength and stiffness properties suitable for structural applications. Among the tested composites, the laminates with randomly oriented bamboo fibers exhibited the highest strength properties. Its strength in flexure, tension, compression, and shear are 58, 35, 48, and 32 MPa, respectively and its Modulus of Elasticity (MOE) is 3.2GPa. However, only the tensile strength and MOE showed better properties to that of neat polyester resin which are 15% and 4% higher, re-spectively possibly due to relatively poor load transfer between the fibers and the matrix. Importantly, the flexural strength of the bamboo fiber-polyester composites is 200% and 30% higher than the standard particleboard and medium density fiberboard, respectively used in the construction industry. It is expected that the results of this preliminary study will provide information to support the development and application of this new generation composites in housing and construction