San Francisco

Abstract not availabl

Heliyon

Purpose: Restraint is often used when administering procedures to children. However, no metrologically scale to measure the restraint intensity had yet been validated. This study validated the metrological criteria of a scale measuring the restraint intensity, Procedural Restraint Intensity in Children (PRIC), used during procedures in children. Design and methods: The PRIC scale performance was measured by a group of 7 health professionals working in a children's hospital, by watching 20 videos of health care procedures. This group included 2 physicians, 1 pediatric resident, and 4 nurses. The intra-class correlation coefficients were calculated to evaluate the inter-rater and test-retest reliability and the construct validity with the correlation between PRIC scale and a numerical rating scale. Results: One hundred and forty measurements were made. Inter-rater and test-retest correlation coefficients were 0.98 and 0.98, respectively. The 2 scales were positively correlated with a Spearman coefficient of 0.93. Conclusions: This study validated the Procedural Restraint Intensity in Children (PRIC) scale in metrological terms with some limitation. However, there is not gold standard scale to precisely validate the reliability of this tool and this study has been conducted in "experimental" conditions. Nevertheless, this is the first scale measuring the intensity of physical restraint with a metrological validation. The next step will be to validate it in real clinical situations

Development and evaluation of a clinical algorithm to monitor patients on antiretrovirals in resource-limited settings using adherence, clinical and CD4 cell count criteria

<p>Abstract</p> <p>Background</p> <p>Routine viral load monitoring of patients on antiretroviral therapy (ART) is not affordable in most resource-limited settings.</p> <p>Methods</p> <p>A cross-sectional study of 496 Ugandans established on ART was performed at the Infectious Diseases Institute, Kampala, Uganda. Adherence, clinical and laboratory parameters were assessed for their relationship with viral failure by multivariate logistic regression. A clinical algorithm using targeted viral load testing was constructed to identify patients for second-line ART. This algorithm was compared with the World Health Organization (WHO) guidelines, which use clinical and immunological criteria to identify failure in the absence of viral load testing.</p> <p>Results</p> <p>Forty-nine (10%) had a viral load of >400 copies/mL and 39 (8%) had a viral load of >1000 copies/mL. An algorithm combining adherence failure (interruption >2 days) and CD4 failure (30% fall from peak) had a sensitivity of 67% for a viral load of >1000 copies/mL, a specificity of 82%, and identified 22% of patients for viral load testing. Sensitivity of the WHO-based algorithm was 31%, specificity was 87%, and would result in 14% of those with viral suppression (<400 copies/mL) being switched inappropriately to second-line ART.</p> <p>Conclusion</p> <p>Algorithms using adherence, clinical and CD4 criteria may better allocate viral load testing, reduce the number of patients continued on failing ART, and limit the development of resistance.</p

New binaries from the SHINE survey

Stars and planetary system

Impact of a corporate social responsibility message on consumers’ sustainable behaviours and purchase intentions

This study investigates the impact of a water brand’s CSR message highlighting the brand’s environmental concerns on brand-related variables (attitude towards the brand and CSR) and consumer-related variables (consumer efforts to adopt sustainable behaviours and well-being). A research model is proposed, and the relationships postulated are tested on 414 French consumers. The study establishes the effectiveness of this kind of CSR messaging in influencing French consumers to purchase and recommend a particular brand. It then shows the direct and indirect ways in which a brand’s CSR messaging can improve consumers’ behavioural intentions (i.e. intentions to purchase the brand’s products and to recommend the brand and/or its products). It also underscores that brand-related variables contribute to increasing brands’, and thus companies’, business performance, whereas consumer-related variables contribute to increasing their social performance. Finally, the REBUS-PLS method emphasises the existence of several consumer groups and identifies the core target customer groups on which companies should focus their communication efforts

Package-free products: How to improve pro-environmental buying behaviors among consumers

The packaging of consumer goods is considered a main cause of household waste. Worldwide institutions are pressing companies to realize solutions that minimize packaging and comply with sustainable development goals (SDGs). Similarly, emerging EU Directives are prompting countries and operators to cut off the packaging of fastmoving consumer goods. The offer of package-free products – alternatively named bulk products – represents an effective solution. Applying a mixed method approach to data collected during and after the pandemic, this paper explores consumers' propensity for bulk products, identifying potential benefits and barriers consumers face when buying package-free products. We find that consumers are keen to buy bulk products not to conform to society but as they perceive it as a personal contribution to environmental protection. However, greater familiarity with package-free products is necessary for adopting this emerging pro-environmental behavior. Thus, we encourage i) manufacturers to develop and propose new package-free lines, ii) retailers to provide package-free assortment options to attract new consumer targets, iii) institutions and policymakers to promote sustainable behavior among citizens favoring familiarity with this shopping option

Package-free products: How to improve pro-environmental buying behaviors among consumers

The packaging of consumer goods is considered a main cause of household waste. Worldwide institutions are pressing companies to realize solutions that minimize packaging and comply with sustainable development goals (SDGs). Similarly, emerging EU Directives are prompting countries and operators to cut off the packaging of fast-moving consumer goods. The offer of package-free products – alternatively named bulk products – represents an effective solution. Applying a mixed method approach to data collected during and after the pandemic, this paper explores consumers’ propensity for bulk products, identifying potential benefits and barriers consumers face when buying package-free products. We find that consumers are keen to buy bulk products not to conform to society but as they perceive it as a personal contribution to environmental protection. However, greater familiarity with package-free products is necessary for adopting this emerging pro-environmental behavior. Thus, we encourage i) manufacturers to develop and propose new package-free lines, ii) retailers to provide package-free assortment options to attract new consumer targets, iii) institutions and policymakers to promote sustainable behavior among citizens favoring familiarity with this shopping option