Improving teaching methods and tools Russian as a foreign language in the course of pre-university training of foreign citizens

Обоснована актуальность совершенствования процессов обучения иностранных граждан русскому языку как иностранному в ходе довузовской подготовки, в том числе в дистанционной форме. Предложены подходы к реализации на современном научно-техническом и научно-методическом уровне электронного образовательного ресурса для самостоятельного изучения русского языка как иностранного на начальном этапе. Дана характеристика методов и средств реализации создаваемого ресурса, оценены перспектив его практического применения. The article substantiates the relevance of improving the processes of teaching Russian as a foreign language to foreign citizens during pre-university training, including in remote form. The article suggests approaches to the implementation of an electronic educational resource for self-study of the Russian language as a foreign language at the initial stage at the modern scientific, technical and scientificmethodological level. The methods and means of implementing the created resource are characterized, and the prospects for its practical application are evaluated

On the implementation of the interactive learning method on the basis of electronic educational resource for studying russian as a foreign language

В статье рассматривается электронный образовательный ресурс по курсу «Русский язык как иностранный» на начальном этапе обучения. Ресурс как элемент структуры учебно-методического обеспечения учебного процесса разрабатывается в Белорусском государственном университете информатики и радиоэлектроники в рамках электронной образовательной среды Moodle. Описаны способы реализации интерактивного метода обучения в рамках электронного образовательного ресурса, которые помогают решить проблему обеспечения коммуникативной компетенции обучающихся в условиях изучения языка самостоятельно или на удалении. The article discusses an electronic educational resource for the course "Russian as a foreign language" at the initial stage of training. The resource as an element of the structure of educational and methodological support of the educational process is being developed at the Belarusian State University of Informatics and Radioelectronics within the framework of the electronic educational environment Moodle. Described are ways of implementing an interactive teaching method within the framework of an electronic educational resource, which help to solve the problem of ensuring the communicative competence of students in the conditions of learning a language independently or at a distance

The Philosophical Concept of Globalization: «Planetism» M. Heidegger

Globalization as a necessary form of the «end of modern times» - the «era of nihilism», is presented by M. Heidegger as the coming domination of planetarism as a worldwide implementation of the idea of technology. «Infinite duration» («inability to perish») as meaninglessness («idiocy») is a characteristic feature of planetarism; globalization is a worldwide form of completion (but not «end») of European history as essentially defined by European metaphysics.Глобализация как необходимая форма «конца нового времени» - «эпохи нигилизма», представлена М. Хайдеггером как наступающее господство планетаризма как всемирное осуществление идеи техники. «Бесконечная длительность» («неспособность к гибели») как обезмысленность («идиотизм») есть характерная черта планетаризма; глобализация есть всемирная форма завершения (но не «конца») европейской истории как существенно определенной европейской метафизикой

Создание рекомбинантного штамма Escherichia coli, продуцирующего субъединицу гомологичного термолабильного токсина

Colibacteriosis is an acute zoonotic disease manifested by septicaemia, toxemia, enteritis, body dehydration, and central nervous system damage. Depending on the presence of virulence factors and the nature of interaction with the intestinal mucosa, enterotoxigenic, enteroinvasive, enteropathogenic, and enterohemorrhagic E. coli are isolated. Enterotoxigenic strains of E. coli occupy one of the leading places in the etiological structure of calf colibacteriosis in many livestock farms of the Republic of Belarus. The main reason why this disease develops is the presence of thermolabile and thermostable toxins in the causative strain. The thermolabile toxin subunit B is a potent antigen that allows pet immunity to be acquired against E. coli-induced cattle diarrhea. Many foreign vaccines used against intestinal infections of cattle contain either a native or recombinant variant of the subunit B. As a result of the work, we have created a new strain of E. coli 42eLTB – the producer of the recombinant subunit B of the thermolabile toxin E. coli. The producing capacity of the obtained strain is 480 mg with 1 culture liquid liter, which exceeds the already known strains 1.37 times.Колибактериоз – это остро протекающая зоонозная болезнь, проявляющаяся септицемией, токсемией, энтеритом, обезвоживанием организма и поражением центральной нервной системы. Энтеротоксигенные штаммы Escherichia coli занимают одно из ведущих мест в этиологической структуре колибактериоза телят во многих животноводческих хозяйствах Республики Беларусь. Основная причина, из-за которой развивается данная болезнь, это наличие термолабильных и термостабильных токсинов в штамме-возбудителе. Субъединица В термолабильного токсина является сильным антигеном, который позволяет домашним животным приобрести иммунитет против диареи крупного рогатого скота, вызванной E. coli. Многие зарубежные вакцины, используемые против кишечных инфекций крупного рогатого скота, содержат в себе либо нативный, либо рекомбинантный вариант субъединицы В. В результате выполнения работы нами создан новый штамм E. coli 42eLTB – продуцент рекомбинантной субъединицы В термолабильного токсина энтеротоксикогенного штамма E. coli. При этом продуцирующая способность полученного штамма составляет 480 мг с 1 л культуральной жидкости, что превышает аналогичный показатель уже известных штаммов в 1,37 раза

Use of Genomic DNA as an Indirect Reference for Identifying Gender-Associated Transcripts in Morphologically Identical, but Chromosomally Distinct, Schistosoma mansoni Cercariae

BACKGROUND: The use of DNA microarray technology to study global Schistosoma gene expression has led to the rapid identification of novel biological processes, pathways or associations. Implementation of standardized DNA microarray protocols across laboratories would assist maximal interpretation of generated datasets and extend productive application of this technology. METHODOLOGY/PRINCIPAL FINDINGS: Utilizing a new Schistosoma mansoni oligonucleotide DNA microarray composed of 37,632 elements, we show that schistosome genomic DNA (gDNA) hybridizes with less variation compared to complex mixed pools of S. mansoni cDNA material (R = 0.993 for gDNA compared to R = 0.956 for cDNA during ‘self versus self’ hybridizations). Furthermore, these effects are species-specific, with S. japonicum or Mus musculus gDNA failing to bind significantly to S. mansoni oligonucleotide DNA microarrays (e.g R = 0.350 when S. mansoni gDNA is co-hybridized with S. japonicum gDNA). Increased median fluorescent intensities (209.9) were also observed for DNA microarray elements hybridized with S. mansoni gDNA compared to complex mixed pools of S. mansoni cDNA (112.2). Exploiting these valuable characteristics, S. mansoni gDNA was used in two-channel DNA microarray hybridization experiments as a common reference for indirect identification of gender-associated transcripts in cercariae, a schistosome life-stage in which there is no overt sexual dimorphism. This led to the identification of 2,648 gender-associated transcripts. When compared to the 780 gender-associated transcripts identified by hybridization experiments utilizing a two-channel direct method (co-hybridization of male and female cercariae cDNA), indirect methods using gDNA were far superior in identifying greater quantities of differentially expressed transcripts. Interestingly, both methods identified a concordant subset of 188 male-associated and 156 female-associated cercarial transcripts, respectively. Gene ontology classification of these differentially expressed transcripts revealed a greater diversity of categories in male cercariae. Quantitative real-time PCR analysis confirmed the DNA microarray results and supported the reliability of this platform for identifying gender-associated transcripts. CONCLUSIONS/SIGNIFICANCE: Schistosome gDNA displays characteristics highly suitable for the comparison of two-channel DNA microarray results obtained from experiments conducted independently across laboratories. The schistosome transcripts identified here demonstrate, for the first time, that gender-associated patterns of expression are already well established in the morphologically identical, but chromosomally distinct, cercariae stage

CASE OF GIANT MEGAURETER IN COMBINATION WITH DOUBLING OF BOTH KIDNEYS IN ADULT PATIENT

An extremely rare clinical case of giant megaureter in an adult patient is described. Megaureter was revealed in examination of the abdominal cavity and retroperitoneal space during surgery for gynecological pathology. Surgical treatment was successful, resection of megaureter with plastic reconstruction of the left ureter with anastomosis "end- to-end" and "end-to-side" on introduced ureteral stents into the lumen was performed. Postoperative examination revealed the presence of megaureter on the right side and doubling of both kidneys