Synthesis, in vitro biological evaluation and molecular docking study of coumarin-1,4-dihydropyridine derivatives as potent anti-inflammatory agents

The green chemistry approach provides for the synthesis of coumarin-1,4-dihydropyridine scaffolds 6a-o via sequential multicomponent reaction using catalytic amount of triethylamine (TEA). These new coumarin scaffolds have been successfully explored for the effective inflammatory as well as microbial infection inhibitors. The antimicrobial activity results of the title compounds have shown potent activity against both gram positive and gram negative bacterial, and fungal stains. Additionally, anti-inflammatory activity of all the compounds has been found to be quite promising in comparison with standard Diclofenac sodium. Furthermore, the in silico docking study has been performed for all the compounds with S. aureus DNA gyrase and cyclooxygenase-2 (PDB ID 4PH9). The computational results are in good agreement with the in vitro antibacterial and anti-inflammatory experimental results.

Synthesis, in vitro biological evaluation and molecular docking study of coumarin-1,4-dihydropyridine derivatives as potent anti-inflammatory agents

418-432The green chemistry approach provides for the synthesis of coumarin-1,4-dihydropyridine scaffolds 6a-o via sequential multicomponent reaction using catalytic amount of triethylamine (TEA). These new coumarin scaffolds have been successfully explored for the effective inflammatory as well as microbial infection inhibitors. The antimicrobial activity results of the title compounds have shown potent activity against both gram positive and gram negative bacterial, and fungal stains. Additionally, anti-inflammatory activity of all the compounds has been found to be quite promising in comparison with standard Diclofenac sodium. Furthermore, the in silico docking study has been performed for all the compounds with S. aureus DNA gyrase and cyclooxygenase-2 (PDB ID 4PH9). The computational results are in good agreement with the in vitro antibacterial and anti-inflammatory experimental results

Synthesis and molecular docking studies of coumarin-imidazole conjugates as potential antimicrobial agents

110-125One-pot multi-component synthesis of tri and tetra-substituted coumarin-imidazole conjugates have been achieved in good to excellent yield under conventional and microwave methods in optimized catalyst condition. Further, they have been evaluated for antimicrobial activity against Gram positive Bacillus flexus and Gram negative Pseudomonas Spp. bacterial strains and two strains of fungi Scopulariopsis spp. and Aspergillus tereus organisms. The results of microbial activity are promising against tested organisms. The molecular docking study has been performed for all the compounds and docking scores are excellent. Synthesized compounds have been characterized by IR, NMR, mass and a few of them by single crystal X-ray analysis

Synthesis, molecular docking, and biological evaluation of methyl-5-(hydroxyimino)-3-(aryl-substituted)hexanoate derivatives

Beta-aryl keto hexanoic acids (5a-l) were synthesized efficiently, followed by esterification that afforded beta-aryl keto methylhexanoates (6a-l). The chemo-selective ketoxime beta-aryl methyl hexanoates (7a-l) were isolated in good yields. Spectroscopic methods were used to characterize the obtained moieties. The antioxidant, anti-inflammatory, and antibacterial properties of the effectively synthesized compounds 7a-l were also investigated. The anti-inflammatory activity of the compounds 7c, 7f, 7i, and 7l was excellent, with a low IC50 value at micromolar concentration, which was much better than the reference diclofenac. All synthesized compounds 7a-l were assessed for their in vitro antibacterial activity against S. aureus, B. subtilis and E. coli.  Most of the compounds exhibited promising activity against Gram-positive bacterial strain, compound 7i showed excellent activity compared to standard streptomycin and in the case of E. coli, compounds 7b, 7c, 7j, 7k and 7l have shown moderate activity. Further, the cytotoxic activities of the compounds were assessed against lung cancer cells (A549) by using MTT assay. The possible interaction mechanism of the molecules 7c and 7g with Gram-negative strain E. coli DNA gyrase B in complex with PDB ID: 4DUH was studied

Dual fluorescence and biological evaluation of paracetamol ethers from 4-bromomethylcoumarins

2416-2422Paracetamol 1 has been reacted with 4-bromomethylcoumarins 2 to obtain the corresponding ethers 3 which have been hydrolyzed to the amino ethers 4. Structure of 4 has been confirmed by the chemoselective reaction of 2 with p-aminophenol, which has also been found to yield the thermodynamically controlled products 5 at elevated temperatures. Compounds 3 have been found to exhibit dual fluorescence. IR,1H NMR and mass spectral data have confirmed structures of all the compounds. Biological evaluation has shown that compounds 3e and 3g show good anti-inflammatory and analgesic properties

Effects of Base for the Efficient Synthesis of 4-Formylcoumarins and 4-Formylcarbostyrils

<div><p></p><p>The first efficient transformation of 4-bromomethylcoumarins and 4-bromomethylcarbostyrils to 4-formylcoumarins and 4-formylcarbostyril under aqueous conditions has been achieved by modifying the Kornblum method, resulting in excellent yield. The experimental method is very simple and economical; no further purification is required and the experimental conditions have been optimized. All the isolated compounds were characterized by infrared, NMR, and mass spectroscopy, and some of the compounds have been analyzed by single-crystal x-ray analysis.</p></div

Green approach for the synthesis of 4-coumarin-4<i>H</i>-pyrans from 4-formylcoumarins and their antibacterial study

<p>A series of 4<i>H</i>-pyranocoumarin derivatives have been successfully synthesized under eco-friendly condition using triethylamine as a catalyst in short reaction time with excellent yield at room temperature. All the synthesized compounds were characterized by spectral analysis and screened for their antibacterial activity against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>, the results are quite promising.</p

Synthesis of coumarin analogous of decursivine derivatives

<p>The first synthesis of decursivine derivatives of coumarins is described via intramolecular Friedel–Craft aromatic alkylation. The Lewis acid (LA)–catalyzed reaction facilitated the rapid construction of the desired product. The targeted molecule obtained has been confirmed by spectral analysis.</p

Network Building Capabilities for a Sustainable and Circular Economy

This research introduces a novel integrated model that affiliates the innovative capacity of circular start-ups, as seen through their network-building capabilities, with the influential attribute of top management support as outlined in the T-O-E theory. The investigation employs a quantitative research methodology based on a random sampling technique for the entire research population. The structural equation model, utilizing SMARTPLS, is used on a dataset comprising 231 manufacturing-based circular start-ups and their franchises in India. The findings reveal significant direct and indirect relationships between network-building capabilities and the innovation function of circular start-ups. The study highlights the pivotal role of top management support, following the T-O-E framework, as a complete mediator between network-building capabilities and organizational innovativeness. This inquiry establishes that effective networking and other factors confer a competitive edge upon firms. Furthermore, it contributes to the literature on the circular economy within emerging markets, offering insights applicable across various sectors like IT, hospitality, aviation, pharmaceuticals, and more. The study's implications extend to future researchers and policymakers, advocating for adopting a multi-level perspective to foster and ensure the innovativeness of circular start-ups in diverse industries