7 research outputs found
Preparation of 2,5-Anhydrohexitols (Part Ii). Intramolecular Nucleophilic Substitution of Cyclic Sulfates
No full textEnantioselective Epoxidation of α,β-Unsaturated Ketones by Phase-Transfer Catalysis Using Chiral Quaternary Ammonium Salts
No full textBiosynthesised ZnO : Dy3+ nanoparticles: Biodiesel properties and reusable catalyst for N-formylation of aromatic amines with formic acid
No full textBenzimidazole Derivatives as Potential Antimicrobial and Antiulcer Agents: A Mini Review
No full textAssessment of analytical techniques for characterization of crystalline clopidogrel forms in patent applications
No full textThe aim of this study was to evaluate two important aspects of patent applications of crystalline forms of drugs: (i) the physicochemical characterization of the crystalline forms; and (ii) the procedure for preparing crystals of the blockbuster drug clopidogrel. To this end, searches were conducted using online patent databases. The results showed that: (i) the majority of patent applications for clopidogrel crystalline forms failed to comply with proposed Brazilian Patent Office guidelines. This was primarily due to insufficient number of analytical techniques evaluating the crystalline phase. In addition, some patent applications lacked assessment of chemical/crystallography purity; (ii) use of more than two analytical techniques is important; and (iii) the crystallization procedure for clopidogrel bisulfate form II were irreproducible based on the procedure given in the patent application
