The state and the church in Russia in the early new age: custom and law

The article is devoted to the analysis of the peculiarities of the system of relations that were formed between the Orthodox Church and the authority of the Russian state in the early modern perio

APPLICATION OF “MOODLE” E-LEARNING SYSTEM IN TEACHING LANGUAGE FOR SPECIFIC PURPOSES

The article presents the development experience of online computer-assisted learning package based on modular object-oriented dynamic learning environment (MOODLE) that is designed to teach a foreign language for specific purposes in non-linguistic university. The developed package allows enhancing the teaching process by creating optimal conditions to realize the principles of teaching differentiation and individualization and also by stimulating the students’ motivation to learn the language through various methods and kinds of teaching tasks

Models for development of the information-control complex of the enterprise

This article provides a brief analysis of the development of concepts and terms used in the automation the processes of production and enterprise management. The conclusion is made about the preference of the term “information-control complex” (ICC) of the enterprise and the expediency of using various concepts in its creation. A model for the development of ICC is proposed, based on the definition of a system that implements the system-target approach, and the “engineering” concept

Prognostic Value of BRCA1 and BRCA2 Gene Mutations in Prostate Cancer: a Literature Review

Prostate malignancies aggressively grow worldwide frequently occurring inoperable at diagnosis. A proper choice of treatment strategy is currently a challenge. Metastatic castration-resistant prostate cancer remains fatal and poor-prognosis, albeit the list of chemotherapeutic agents and androgen receptor signalling inhibitors has recently been extending towards a certain therapeutic success. Numerous studies suggest a frequent association of the unfavourable prognosis with germline or somatic damage of DNA repair genes. Such are mutations in the BRCA1 and BRCA2 genes bearing important clinical implications for the patient outcome through an adverse clinical manifest of primary tumours and poor treatment in metastatic castration-resistant prostate cancer. This review attempts to describe the BRCA1/2 mutations in prostate cancer with a focus on their prognostic value

Evaluation of the microstructure and mechanical properties of a new modified cast and laser-melted AA7075 alloy

The mechanical properties and microstructure of as-cast and homogenized AA7075 were investigated. This alloy was modified by adding transition elements 0.3%Sc + 0.5%Zr, 1%Ti + 0.2%B, and 1%Fe + 1%Ni for use in additive manufacturing applications. After adding Ti + B and Sc + Zr, the structure became uniform and finer with the formation of the Al3(Sc, Zr) and TiB2 phases. Coarse structures were obtained with the formation of an extremely unfavorable morphology, close to a needle-like structure when Fe + Ni was added. The mechanical properties of the modified alloys were increased compared to those of the standard alloy, where the best ultimate tensile strength (UTS) and yield strength (YS) were obtained in the AA7075-TiB alloy compared to the standard alloy in as-cast and homogenized conditions, and the highest hardness value was provided by Fe + Ni additives. The effect of the laser melting process on the microstructure and mechanical properties was investigated. Single laser melts were performed on these alloys using 330 V and a scanning speed of 8 mm/s. During the laser melting, the liquation of the alloying elements occurred due to non-equilibrium solidification. A change in the microstructures was observed within the melt zone and heat-affected zone (HAZ). The hardness of the laser-melted zone (LMZ) after adding the modification elements was increased in comparison with that of the standard alloy. Corrosion testing was performed using a solution of 100 mL distilled water, 3.1 g NaCl, and 1 mL HCl over 5, 10, and 30 min and 1 and 2 h. The corrosion resistance of the alloy modified with FeNi was low because of the non-uniform elemental distribution along the LMZ, but in the case of modification with ScZr and TiB, the corrosion resistance was better compared to that of the standard alloy. © 2019 by the authors.Ministry of Science and Higher Education of the Russian FederationThe author (Asmaa M. Khalil) gratefully acknowledges financial support from the Ministry of Science and Higher Education of the Russian Federation in the framework of Increase Competitiveness Program of MISiS (Support project for young research engineers)

THE USE OF NEW REAGENT KITS FOR DETECTION AND DESCRIPTION OF ADDITIONAL ALLELES

During the screening typing of recruited volunteers with Volga Federal District for unrelated hematopoietic stem cell registry on the loci (HLA)-A, B, DRB1, DRB345 in sample No 1758 identified a new allele at locus A. The use of basic kit AlleleSEQR HLA-A Sequencing in combination with HARP – A2F98A allowed to determine the genotype of this sample – А*30:01:01, a new allele А*25, В*13, 44, DRB1*03, 09, DRB3*02, DRB4*01

New triphenylphosphonium salts from a cyclic 2,3-dichloro-4-oxobut-2-enoic acid and its esters. Synthesis of an unusual phosphonium betaine

PPh3 reacts with a cyclic 2,3-dichloro-4-oxobut-2-enoic acid and its cyclic and acyclic esters to form new triphenylphosphonium salts. Treatment of the obtained salts with triethylamine leads to an unusual phosphonium betaine. © 1996 MAEe cyrillic signK Hayκa/Interperiodica Publishing

Reaction of P(III) Organyl Halides with 3,4-Dichloro-5-hydroxy-2(5H)-furanone

Reaction of diphenylchlorophosphine with 3,4-dichloro-5-hydroxy-2(5H)-furanone was used to prepare 3,5-dichloro-4-diphenylphosphinoyl-2(5H)-furanone. The reaction occurs involves nucleophilic substitution of the chlorine β to the carbonyl group and an unusual intermolecular rearrangement. The reaction with diethyl phosphorochloridite takes two routes: The first route is similar to that with diphenylchlorophosphine and the second involves the hydoxyl group

New Reaction of 3,4-Dichloro-5-hydroxy-2(5H)-furanone with Trimethylsilylphosphites

The new reaction path of the phosphorylation of 3,4-dichloro-5-hydroxy-2(5H)-furanone with trimethylsilylphosphite is found. It is established that the reaction involves two reaction centres to give 4- and 5-phosphorylation products

ПОЛУЧЕНИЕ АКТИВНОГО ОКСИДА АЛЮМИНИЯ И НИЗКОПЛАВКОГО ЭЛЕКТРОЛИТА

There was examined a possibility of activated alumina obtaining with extended specific surface y using of pseudoboehmite. There were conducted tests of given product dissolution in low-melting electrolyte with furthering usage of it’s at electrowinning of aluminum.For comparison of low-melting and commercial electrolyte were applied different modern physicochemical analysis methods. There was demonstrated that low-melting electrolyte has complete other constitution, and consist not from mix of fluorides as artificial electrolyte, but possessed of ionic constitution. There was demonstrated a possibility of electrochemical obtaining of aluminum attemperature 780 °CИзучена возможность получения активного оксида алюминия с развитой удельной поверхностью с использованием псевдобемита. Проведены испытания растворения данного продукта в низкоплавком электролите с дальнейшим использованием его при электролитическом получении алюминия. Для сравнения низкоплавкого и промышленного электролитов были применены различные современные физико-химические методы анализа. Показано, что низкоплавкий электролит имеет совершенно другое строение и состоит не из смеси фтористых солей, как искусственный электролит, а обладает ионным строением. Показана возможность проведения электрохимического получения алюминия при температуре 780 °С