Formation of phase structure in the system Ti-3Al at the stage of secondary structurization at synthesis in the mode of thermal explosion

Features of phase formation processes in the system Ti-3Al at realization of self-extending synthesis in the mode of thermal explosion have been established with use of technological reactor enabling instant switching-off of the heating source. The analysis of synthesis finished products allows to draw a conclusion that phase structure of charge is abnormally depends on sizes of titanium particles. The single-phase product corresponding to initial stoichiometry is synthesized on fine and large fractions for the induction period. On intermediate fraction the product of synthesis is multiphas

Formation of phase structure in the system Ti-3Al at the stage of secondary structurization at synthesis in the mode of thermal explosion

Features of phase formation processes in the system Ti-3Al at realization of self-extending synthesis in the mode of thermal explosion have been established with use of technological reactor enabling instant switching-off of the heating source. The analysis of synthesis finished products allows to draw a conclusion that phase structure of charge is abnormally depends on sizes of titanium particles. The single-phase product corresponding to initial stoichiometry is synthesized on fine and large fractions for the induction period. On intermediate fraction the product of synthesis is multiphas

Single-Crystal Organic Field Effect Transistors with the Hole Mobility ~ 8 cm2/Vs

We report on the fabrication and characterization of single-crystal organic p-type field-effect transistors (OFETs) with the field-effect hole mobility mu \~ 8 cm2/Vs, substantially higher than that observed in thin-film OFETs. The single-crystal devices compare favorably with thin-film OFETs not only in this respect: the mobility for the single-crystal devices is nearly independent of the gate voltage and the field effect onset is very sharp. Subthreshold slope as small as S = 0.85 V/decade has been observed for a gate insulator capacitance Ci = 2 +- 0.2 nF/cm2. This corresponds to the intrinsic subthreshold slope Si = SCi at least one order of magnitude smaller than that for the best thin-film OFETs and amorphous hydrogenated silicon (a-Si:H) devices

Prognostic Value of BRCA1 and BRCA2 Gene Mutations in Prostate Cancer: a Literature Review

Prostate malignancies aggressively grow worldwide frequently occurring inoperable at diagnosis. A proper choice of treatment strategy is currently a challenge. Metastatic castration-resistant prostate cancer remains fatal and poor-prognosis, albeit the list of chemotherapeutic agents and androgen receptor signalling inhibitors has recently been extending towards a certain therapeutic success. Numerous studies suggest a frequent association of the unfavourable prognosis with germline or somatic damage of DNA repair genes. Such are mutations in the BRCA1 and BRCA2 genes bearing important clinical implications for the patient outcome through an adverse clinical manifest of primary tumours and poor treatment in metastatic castration-resistant prostate cancer. This review attempts to describe the BRCA1/2 mutations in prostate cancer with a focus on their prognostic value

Development of the optimal mode of bleaching of linen materials by periodic method

The article presents the results of research on the operational properties of linen material bleached by the developed combined periodic method. The influence of the composition and concentration of components in the working solution on the quality indicators of bleaching was studied. The results of the study show that the use of the proposed combined method for bleaching linen and mixed fabrics allows you to obtain high values of the degree of whiteness and capillarity with the preservation of strength indicators and minimal destruction of cellulose fiber

Evaluation of the microstructure and mechanical properties of a new modified cast and laser-melted AA7075 alloy

The mechanical properties and microstructure of as-cast and homogenized AA7075 were investigated. This alloy was modified by adding transition elements 0.3%Sc + 0.5%Zr, 1%Ti + 0.2%B, and 1%Fe + 1%Ni for use in additive manufacturing applications. After adding Ti + B and Sc + Zr, the structure became uniform and finer with the formation of the Al3(Sc, Zr) and TiB2 phases. Coarse structures were obtained with the formation of an extremely unfavorable morphology, close to a needle-like structure when Fe + Ni was added. The mechanical properties of the modified alloys were increased compared to those of the standard alloy, where the best ultimate tensile strength (UTS) and yield strength (YS) were obtained in the AA7075-TiB alloy compared to the standard alloy in as-cast and homogenized conditions, and the highest hardness value was provided by Fe + Ni additives. The effect of the laser melting process on the microstructure and mechanical properties was investigated. Single laser melts were performed on these alloys using 330 V and a scanning speed of 8 mm/s. During the laser melting, the liquation of the alloying elements occurred due to non-equilibrium solidification. A change in the microstructures was observed within the melt zone and heat-affected zone (HAZ). The hardness of the laser-melted zone (LMZ) after adding the modification elements was increased in comparison with that of the standard alloy. Corrosion testing was performed using a solution of 100 mL distilled water, 3.1 g NaCl, and 1 mL HCl over 5, 10, and 30 min and 1 and 2 h. The corrosion resistance of the alloy modified with FeNi was low because of the non-uniform elemental distribution along the LMZ, but in the case of modification with ScZr and TiB, the corrosion resistance was better compared to that of the standard alloy. © 2019 by the authors.Ministry of Science and Higher Education of the Russian FederationThe author (Asmaa M. Khalil) gratefully acknowledges financial support from the Ministry of Science and Higher Education of the Russian Federation in the framework of Increase Competitiveness Program of MISiS (Support project for young research engineers)

THE USE OF NEW REAGENT KITS FOR DETECTION AND DESCRIPTION OF ADDITIONAL ALLELES

During the screening typing of recruited volunteers with Volga Federal District for unrelated hematopoietic stem cell registry on the loci (HLA)-A, B, DRB1, DRB345 in sample No 1758 identified a new allele at locus A. The use of basic kit AlleleSEQR HLA-A Sequencing in combination with HARP – A2F98A allowed to determine the genotype of this sample – А*30:01:01, a new allele А*25, В*13, 44, DRB1*03, 09, DRB3*02, DRB4*01

Investigation of influence of parameters of laser welding on microstructure and mechanical properties of Al-4.7%Mg -0.32%Mn-0.21%Sc-0.09%Zr alloy

В работе исследовано влияние пиковой мощности (0,64–1,31 кВт) при напряжениях из диапазона 330–430 В при лазерной сварке со стандартным диаметром пучка и длительностью импульса 8 мс. Изучена микроструктура, сформированная сваркой. Установлено, что существует разноообразие в размерах и форме зерен в зоне шва. Показано, что с увеличением пиковой мощности ширина и глубина области шва увеличивается.In the present work the influence of peak power of laser beam welding were studied at voltage range from 330 to 430 V and peak power (0,64; 0,75; 0,87; 1,01; 1,15; 1,31) kW , and laser beam diameter is standard and duration 8 ms. The microstructure after welding was studied. It was concluded that there is a variant in grain size and shape in the welded zone and pre-welded area. The dimensions of welded zone was measured. From measuring data, it was observed, that as increasing the peak power the width and depth of welding increased.The work was performed as part of the state work "Carrying out of research work (basic research, applied research and experimental development)" state task MES of Russia in the sphere of scientific activities 2014–2016. (Task № 2014/113)

Realization of the Conditions for Provision of Early Intervention in the Russian Federation

В статье раскрываются условия обеспечения доступности ранней помощи в Российской Федерации детям-инвалидам и видов помощи, в которых они нуждаются.The article discloses the conditions for ensuring the availability of early intervention in the Russian Federation, taking into account the ratio of the number of children with disabilities and the types of assistance they need to overcome the barriers that prevent them from receiving services at social, engineering and transport infrastructure facilities on an equal basis with other persons

Models and automation technologies for the curriculum development

The aim of the research was to determine the sequence of the curriculum development stages on the basis of the system analysis, as well as to create models and information technologies for the implementation of thesestages.The methods and the models of the systems’ theory and the system analysis, including methods and automated procedures for structuring organizational aims, models and automated procedures for organizing complex expertise.On the basis of the analysis of existing studies in the field of curriculum modeling, using formal mathematical language, including optimization models, that help to make distribution of disciplines by years and semesters in accordance with the relevant restrictions, it is shown, that the complexity and dimension of these tasks require the development of special software; the problem of defining the input data and restrictions requires a large time investment, that seems to be difficult to provide in real conditions of plans’ developing, thus it is almost impossible to verify the objectivity of the input data and the restrictions in such models. For a complete analysis of the process of curriculum development it is proposed to use the system definition, based on the system-targeted approach. On the basis of this definition the reasonable sequence of the integrated stages for the development of the curriculum was justified: 1) definition (specification) of the requirements for the educational content; 2) determining the number of subjects, included in the curriculum; 3) definition of the sequence of the subjects; 4) distribution of subjects by semesters. The models and technologies for the implementation of these stages of curriculum development were given in the article: 1) models, based on the information approach of A.Denisov and the modified degree of compliance with objectives based on Denisov’s evaluation index (in the article the idea of evaluating the degree of the impact of disciplines for realization of competences was used); 2) models to define the sequence of subjects from curriculum: a) the models, based on evaluating the relationship between the disciplines, using simplicial complex theory, b) the models, implemented by means of information search, using the information retrieval language with the grammar, containing the system of predicates. To implement the models, the automated dialogue procedures were developed.Models have been tested during the process of the development and the adjustment of the working curriculum for bachelor’s and master’s degree programs in the fields «System Analysis and Management», «Information Systems and Technologies», «Applied Informatics»