Hypertension in Holmes County, Mississippi / CAC No. 138

Includes bibliographic references (p. 10-11)

Community conrol, Holmes County, Mississippi / CAC No. 144

Includes bibliographic references.Working for human needs in Holmes County : a grassroots view. Bernice Montgomery.Biosocial assessment of a population : a tool for research and health action. Demitri B. Shimkin.Community organizations and effective health research : operationalizing the program. Dennis A. Frate and William I. Peltz.Recruiting, hiring and training of the local staff : a combined effort. Eddie W. Logan and Erma Jean Polk.The endemic nature of hypertension and the pilot program for community control : from research to service. Edward J. Eckenfels and James A. Schoenberger

DNA damage contributes to transcriptional and immunological dysregulation of testicular cells during Chlamydia infection

Chlamydia is the most commonly reported sexually transmitted bacterial infection, with 127 million notifications worldwide each year. Both males and females are susceptible to the pathological impacts on fertility that Chlamydia infections can induce. However, male chlamydial infections, particularly within the upper reproductive tract, including the testis, are not well characterized. In this study, using mouse testicular cell lines, we examined the impact of infection on testicular cell lineage transcriptomes and potential mechanisms for this impact. The somatic cell lineages exhibited significantly fragmented genomes during infection. Likely resulting from this, each of the Leydig, Sertoli and germ cell lineages experienced extensive transcriptional dysregulation, leading to significant changes in cellular biological pathways, including interferon and germ-Sertoli cell signalling. The cell lineages, as well as isolated spermatozoa from infected mice, also contained globally hypomethylated DNA. Cumulatively, the DNA damage and epigenetic-mediated transcriptional dysregulation observed within testicular cells during chlamydial infection could result in the production of spermatozoa with abnormal epigenomes, resulting in previously observed subfertility in infected animals and congenital defects in their offspring.</p

Sex- associated differences in pathology burden in early- onset Alzheimer- s disease

BackgroundPrevious research has suggested that, compared to males, females are at greater risk for and have greater pathology burden in late onset. However, sex differences in early onset AD (EOAD) have not yet been studied.MethodWe included 167 participants [28 cognitively normal (CN, 68% females), 98 early onset AD (EOAD, 55% females), and 41 cognitively impaired amyloid- negative (EOnonAD, 31% females] subjects from the Longitudinal Early- Onset AD Study (LEADS) with available Flortaucipir PET, Florbetaben PET, and MRI data. Multiple linear regression (MLR) models including age and MMSE as covariates were used in the pooled sample to examine the effects of sex on hippocampal and white matter hyperintensity volume, mean cortical thickness, mean tau distribution by Braak regions and mean cortical amyloid SUVR. We also ran voxelwise MLR with sex as the predictor and cortical thickness, amyloid SUVR normalized to whole cerebellum, tau SUVR normalized to cerebellar crus, respectively, as the outcome measures while controlling for age, MMSE, and total intracranial volume (MRI only). Results are displayed at a cluster- level FWE correction of p<0.05.ResultThere were no significant demographic differences between males and females in any diagnostic group. Across the pooled sample females showed significantly greater atrophy of the hippocampus (p=0.0001), greater tau SUVR in Braak regions 3&4 (p=0.05) and 5&6 (p=0.04) and trend for greater global amyloid uptake (p=0.074) (Table 2). The analyses in imaging space confirmed these findings and showed that the effects are driven by the EOAD group. Females showed greater amyloid deposition globally and greater tau deposition in the frontal, inferior parietal and temporal lobes (Figure 3).ConclusionFemale sex is associated with greater pathology burden in EOAD. Longitudinal studies will be needed to establish whether such difference translates in faster rates of progression in women relative to men.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/163899/1/alz046532.pd

AU CLAIR DE VENUS / Jeff W. HIGGINBOTHOM et son Orchestre

Titre uniforme : [Come softly to me]Titre uniforme : [Personality]Titre uniforme : [Vénus]Titre uniforme : [Personnality]Titre uniforme : [Adieu tristesse = Felicidade]Titre uniforme : [Tout doux, tout doucement = Come softly to me]Titre uniforme : [Marchand de bonheur]Comprend : VENUS / F. [sic] MARSHALL - OUAH - OUAH-OUAH / Sacha DISTEL - NE JOUE PAS / A.J. MAROTTA et G. HEMRIC - ADIEU TRISTESSE / A.C. JOBIM - OH ! QUELLE NUIT / D. GIBSON - UN MONDE ENTIER / R. ADDINSELL - LE TANGO MILITAIRE / E. KOTSCHER - PERSONNALITE / H. LOGAN - L. PRICE - MILLORD / Marguerite MONNOT - LE TEMPS DU MUGUET / B. SOLOVIEV ; SEDOV - MARIE, MARIE / Gilbert BECAUD - LA DANSE DU CHAT / Eddie BARCLAY - Leo MISSIR - LOVE IN PORTOFINO / F. BUSCAGLIO - LE MARCHAND DE BONHEUR / J.P. CALVET - TOUT DOUCEMENT / TRAXEL - CHRISTOPHER - ELLIS - MARCHE DE BABETTE / Gilbert BECAUDBnF-Partenariats, Collection sonore - BelieveContient une table des matière