1,949 research outputs found
Laue Lens Development for Hard X-rays (>60 keV)
Results of reflectivity measurements of mosaic crystal samples of Cu (111)
are reported. These tests were performed in the context of a feasibility study
of a hard X-ray focusing telescope for space astronomy with energy passband
from 60 to 600 keV. The technique envisaged is that of using mosaic crystals in
transmission configuration that diffract X-rays for Bragg diffraction (Laue
lens). The Laue lens assumed has a spherical shape with focal length . It is
made of flat mosaic crystal tiles suitably positioned in the lens. The samples
were grown and worked for this project at the Institute Laue-Langevin (ILL) in
Grenoble (France), while the reflectivity tests were performed at the X-ray
facility of the Physics Department of the University of Ferrara.Comment: 6 pages, 12 figures, accepted for publication in IEEE Transactions on
Nuclear Scienc
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Evaluating the Impact of PSA as a Selection Criteria for Nerve Sparing Radical Prostatectomy in a Screened Cohort
Purpose. We investigated whether NS-RP increased risk of PSA failure and whether PSA should be included as a selection criterion for NS. Methods:. We evaluated 357 consecutive men with screen-detected PC who underwent open RP without adjuvant radiotherapy between 9/11/2001 and 12/30/2008. Criteria for NS included Gleason score ≤3 + 4, percentage of positive biopsies (PPB) ≤50%, percentage of core involvement ≤50%, nonapical location, no perineural invasion, and no palpable disease on pre- or intraoperative exam but did not include a PSA threshold. Cox multivariable regression assessed whether increasing PSA or unilateral- or bilateral-NS versus non-NS-RP was associated with PSA failure adjusting for prognostic factors. Results:. After a median follow-up of 3.96 years, 34 men sustained PSA failure (9.5%). Increasing PSA was significantly associated with increased risk of PSA failure in the interaction model (adjusted hazard ratio (AHR): 1.09 [95% CI: 1.03–1.16]; P = 0.005), whereas unilateral (AHR: 1.24 [95% CI: 0.36–4.34]; P = 0.73) or bilateral NS (AHR: 0.41 [95% CI: 0.06–2.59]; P = 0.34) versus non-NS RP was not. Conclusion:. NS-RP in a screened cohort did not increase risk of PSA failure using NS criteria not including PSA
Oxidative stress-mediated platelet CD40 ligand upregulation in patients with hypercholesterolemia: effect of atorvastatin
Objectives: We speculated that in patients with hypercholesterolemia CD40L overexpression could depend on low-density lipoprotein (LDL)-induced enhanced intraplatelet formation of O-2(.-) and statin could reduce platelet CD40L via interference with platelet O-2(.-) production. Background: CD40L is a protein with inflammatory and thrombotic properties. CD40L is upregulated in platelets from hypercholesterolemic (HC) patients but the underlying mechanism is unclear. Methods: Collagen-induced platelet CD40L and platelet O-2(.-) expression were investigated in 40 HC patients and 40 healthy subjects. HC patients were then randomized to either a diet (n = 20) (group A) or atorvastatin 10 mg day (n = 20) (group B); the above variables were measured at baseline and after 3 and 30 days of treatment. O-2(.-) and CD40L were also measured in vitro in LDL-treated platelets with or without nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitor or atorvastatin added. Results: Compared with controls, HC patients showed higher values of platelet CD40L (P < 0.001) and O-2(.-) (P < 0.001). Platelet CD40L was significantly correlated with O-2(.-) (P < 0.001). The interventional trial showed no changes in group A and a significant and parallel decrease in platelet CD40L (P < 0.001) and O-2(.-) (P < 0.001) in group B. In vitro studies demonstrated that LDL-induced platelet CD40L and GP IIb/IIIa (PAC1 binding) activation via the NADPH oxidase pathway. CD40L upregulation was counteracted by atorvastatin in a dose-dependent fashion. Conclusions: This study suggests that in patients with hypercholesterolemia platelet CD40L is upregulated via NADPH oxidase-dependent O-2(.-) generation. Atorvastatin downregulated CD40L with an oxidative stress-mediated mechanism likely involving platelet NADPH oxidase, an effect that seemed to be independent of its cholesterol-lowering action
Exploring the Hard X-/soft gamma-ray Continuum Spectra with Laue Lenses
The history of X-ray astronomy has shown that any advancement in our
knowledge of the X-ray sky is strictly related to an increase in instrument
sensitivity. At energies above 60 keV, there are interesting prospects for
greatly improving the limiting sensitivity of the current generation of direct
viewing telescopes (with or without coded masks), offered by the use of Laue
lenses. We will discuss below the development status of a Hard X-Ray focusing
Telescope (HAXTEL) based on Laue lenses with a broad bandpass (from 60 to 600
keV) for the study of the X-ray continuum of celestial sources. We show two
examplesof multi-lens configurations with expected sensitivity orders of
magnitude better ( photons cm s keV
at 200 keV) than that achieved so far. With this unprecedented sensitivity,
very exciting astrophysical prospects are opened.Comment: 4 pages, 10 figures, to be published in the Proc. of the 39th ESLAB
Symosium, 19-21 April 200
New results on focusing of gamma-rays with Laue lenses
We report on new results on the development activity of broad band Laue
lenses for hard X-/gamma-ray astronomy (70/100-600 keV). After the development
of a first prototype, whose performance was presented at the SPIE conference on
Astronomical Telescopes held last year in Marseille (Frontera et al. 2008), we
have improved the lens assembling technology. We present the development status
of the new lens prototype that is on the way to be assembled.Comment: 8 pages, 11 figures, to be Published in SPIE Proceedings,
vol.7437-19, 200
Development status of a Laue lens project for gamma-ray astronomy
We report the status of the HAXTEL project, devoted to perform a design study
and the development of a Laue lens prototype. After a summary of the major
results of the design study, the approach adopted to develop a Demonstration
Model of a Laue lens is discussed, the set up described, and some results
presented.Comment: 11 pages, 11 figures, 2007 SPIE Conference on Optics for EUV, X-Ray,
and Gamma-Ray Astronomy II
Feasibility study of a Laue lens for hard X-rays for space astronomy
We report on the feasibility study of a Laue lens for hard X-rays (>60
keV)based on mosaic crystals, for astrophysical applications. In particular we
discuss the scientific motivations, its functioning principle, the procedure
followed to select the suitable crystal materials, the criteria adopted to
establish crystal dimensions and their distribution on the lens in order to
obtain the best lens focusing capabilities, and the criteria for optimizing the
lens effective area in a given passband. We also discuss the effects of
misalignments of the crystal tiles due to unavoidable mechanical errors in
assembling the lens. A software was developed to face all these topics and to
evaluate the expected lens performance.Comment: 10 pages, corrected Fig. 1b and Fig. 2, which are wrong in the
published version, corrected typo
The immune landscape of thyroid cancer in the context of immune checkpoint inhibition
Immune cells play critical roles in tumor prevention as well as initiation and progression. However, immune-resistant cancer cells can evade the immune system and proceed to form tumors. The normal microenvironment (immune cells, fibroblasts, blood and lymphatic vessels, and interstitial extracellular matrix (ECM)) maintains tissue homeostasis and prevents tumor initiation. Inflammatory mediators, reactive oxygen species, cytokines, and chemokines from an altered microenvironment promote tumor growth. During the last decade, thyroid cancer, the most frequent cancer of the endocrine system, has emerged as the fifth most incident cancer in the United States (USA), and its incidence is steadily growing. Inflammation has long been associated with thyroid cancer, raising critical questions about the role of immune cells in its pathogenesis. A plethora of immune cells and their mediators are present in the thyroid cancer ecosystem. Monoclonal antibodies (mAbs) targeting immune checkpoints, such as mAbs anti-cytotoxic T lymphocyte antigen 4 (anti-CTLA-4) and anti-programmed cell death protein-1/programmed cell death ligand-1 (anti-PD-1/PD-L1), have revolutionized the treatment of many malignancies, but they induce thyroid dysfunction in up to 10% of patients, presumably by enhancing autoimmunity. Combination strategies involving immune checkpoint inhibitors (ICIs) with tyrosine kinase (TK) or serine/threonine protein kinase B-raf (BRAF) inhibitors are showing considerable promise in the treatment of advanced thyroid cancer. This review illustrates how different immune cells contribute to thyroid cancer development and the rationale for the antitumor effects of ICIs in combination with BRAF/TK inhibitors
Albumin supplementation dampens hypercoagulability in COVID-19. A preliminary report
Coronavirus disease 2019 (COVID-19) is characterized by
severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) needing mechanical ventilation and intensive care
unit (ICU) treatment. In addition to lung disease, clinical
features of SARS-CoV-2 include myocardial damage and
ischemia-related vascular disease, which are associated
with a hypercoagulable state (e.g., high D-dimer levels)
predisposing to thrombotic-related complications and eventually death.1–3 Serum albumin levels <3.5 g/dL are detectable in SARS-CoV-2 patients and associated with death4 and
elevated D-dimer and thrombotic events,5 which is in accordance with previous studies reporting an association between serum albumin <3.5 g/dL and risk of venous and
arterial thrombosis.6 Thus, we tested the hypothesis that
albumin supplementation could dampen hypercoagulability
in SARS-CoV-2 with serum albumin <3.5 g/dL.
This is an observational cohort study performed at a large
university hospital located in Rome and Chieti (Italy) and
devoted to COVID-19 care
Measurement of the transition form factor with the KLOE detector
A measurement of the vector to pseudoscalar conversion decay with the KLOE experiment is presented. A sample of signal
events was selected from a data set of 1.7 fb of collisions at
collected at the DANE collider. These
events were used to obtain the first measurement of the transition form factor
and a new measurement of the branching ratio of the
decay: . The result improves
significantly on previous measurements and is in agreement with theoretical
predictions.Comment: 13 pages, 4 figures; matches published versio
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