Game Collection Development and Marketing

The reasons for completing this project include expanding my knowledge of programming features and methodology, and to learn about game platform development and design. This was done by using the Java programming language to create a game platform which can host a variable number of games. One of the most notable features that was utilized is the JavaFX platform. Much programming experience was gained from this platform and all the features and methods it provides for customization. The application that was produced is graphical user interface based and created with event-driven programming. The result of this project was a custom game platform and a couple of games that can be played from the platform

Experience with posttransplant lymphoproliferative disorders in solid organ transplant recipients

Nearly 6000 solid organ transplants have been performed at the University of Pittsburgh since 1981. Posttransplant lymphoproliferative disorders (PTLD) have occurred in 131 patients, at a frequency of 2.2%. The majority of cases manifest within 6 months following allograft, but individual lesions may arise several years thereafter. From 1981 to 1989, cyclosporine-A (CsA) served as the primary immunosuppressant in this population. In March of 1989, FK506 was introduced for clinical trials. Since that time, 1421 patients have received FK506 either for primary immunosuppression or as rescue therapy. The frequency of PTLD in this subpopulation is 1.5%. PTLD arising under FK506-containing regimens have clinicopathologic features similar to those arising with CsA immunosuppression. The frequency of PTLD at this point in time is approximately 1%, in kidney allograft patients, 2.7% in liver, 3.3% in heart and 3.8%, in heart/lung or lung recipients. An understanding of the range of histologic appearance is important for the diagnosis of PTLD, especially when it involves the allograft itself. Immunoglobulin heavy chain gene analysis shows that lesions with no rearrangements or with a rearrangement in only a small proportion of cells are more likely to respond to reduced immunosuppression than are those with clonal rearrangement involving a high proportion of cells. However, this distinction is not absolute, and a trial of reduced immunosuppression appears to be indicated regardless of clonal status

Comparison of two methods in deriving a short version of oral health-related quality of life measure

Objective To compare two methods of developing short forms of the Malaysian Oral Health Impact Profile (OHIP-M) measure. Method Cross sectional data obtained using the long form of the OHIP-M was used to produce two types of OHIP-M short forms, derived using two different methods; namely regression and item frequency methods. The short version derived using a regression method is known as Reg-SOHIP(M) and that derived using a frequency method is known as Freq-SOHIP(M). Both short forms contained 14 items. These two forms were then compared in tenus of their content, scores, reliability, validity and the ability to distinguish between groups. Results Out of 14 items, only four were in common. The form derived from the frequency method contained more high prevalence items and higher scores than the form derived from the regression method. Both methods produced a reliable and valid measure. However, the frequency method produced a measure, which was slightly better in terms of distinguishing between groups. Conclusion Regardless of the method used to produce the measures, both forms performed equally well when tested for their cross-sectional psychometric properties. This record was migrated from the OpenDepot repository service in June, 2017 before shutting down

The Role of Gap Filaments in Muscle and in Meat

The neglected gap filaments are now beginning to receive close attention in several centers, in terms of organisation, composition and function. The author\u27s model for their connections gave them a role as cores to A-filaments. This review attempts to weigh the implications of such a role, and relevant evidence, old and new. New ideas arising largely from PAGE*and immunochemkal studies on candidate proteins, and from the developing concept of the cytoskeleton, are considered. The author\u27s theory of meat tenderness, based on G-filaments, has been tested by PAGE studies on changes in the large structural proteins (particularly titin and nebulin) during tenderising treatments. The results, together with those from parallel work elsewhere, are in some conflict with the theory

Stroop Interference in a Delayed Match-To-Sample Task: Evidence for Semantic Competition

Discussions of the source of the Stroop interference effect continue to pervade the literature. Semantic competition posits that interference results from competing semantic activation of word and color dimensions of the stimulus prior to response selection. Response competition posits that interference results from competing responses for articulating the word dimension vs. the color dimension at the time of response selection. We embedded Stroop stimuli into a delayed match-to-sample (DMTS) task in an attempt to test semantic and response competition accounts of the interference effect. Participants viewed a sample color word in black or colored fonts that were ongruent or incongruent with respect to the color word itself. After a 5 s delay, participants were presented with two targets (i.e., a match and a foil) and were instructed to select the correct match. We probed each dimension independently during target presentations via color targets (i.e., two colors) or word targets (i.e., two words) and manipulated whether the semantic content of the foil was related to the semantic content of the irrelevant sample dimension (e.g., word sample “red” in blue font with the word “red” as the match and the word “blue” as the foil). We provide evidence for Stroop interference such that response times (RTs) increased for incongruent trials even in the presence of a response option with semantic content unrelated to the semantic content of the irrelevant sample dimension. Accuracy also deteriorated during the related foil trials. A follow-up experiment with a 10 s delay between sample and targets replicated the results. Results appear to provide converging evidence for Stroop interference in a DMTS task in a manner that is consistent with an explanation based upon semantic competition and inconsistent with an explanation based upon response competition

Circularization of flavivirus genomic RNA inhibits de novo translation initiation.

Members of the Flaviviridae family, including dengue virus (DENV) and yellow fever virus, cause serious disease in humans, whilst maternal infection with Zika virus (ZIKV) can induce microcephaly in newborns. Following infection, flaviviral RNA genomes are translated to produce the viral replication machinery but must then serve as a template for the transcription of new genomes. However, the ribosome and viral polymerase proceed in opposite directions along the RNA, risking collisions and abortive replication. Whilst generally linear, flavivirus genomes can adopt a circular conformation facilitated by long-range RNA-RNA interactions, shown to be essential for replication. Using an in vitro reconstitution approach, we demonstrate that circularization inhibits de novo translation initiation on ZIKV and DENV RNA, whilst the linear conformation is translation-competent. Our results provide a mechanism to clear the viral RNA of ribosomes in order to promote efficient replication and, therefore, define opposing roles for linear and circular conformations of the flavivirus genome

Identifying a human rights–based approach to obesity for States and civil society

Summary Obesity and its comorbidities pose daunting challenges to global health and development in the 21st century. This paper reviews some commonalities between obesity and another global health challenge, the pandemic of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS). International human rights law was an important catalyst for civil society movements that helped to overcome inertia and generate political will for State action in response to HIV and AIDS. Drawing on the HIV experience, the authors propose a conceptual model for a human rights?based response to obesity founded on the twin pillars of State obligations and civil society engagement. Framing States' obligations to address the global obesity pandemic as a matter of international law, informed by the examples of the United Nations ?International Guidelines on HIV/AIDS and Human Rights? and the General Comments of the United Nations human rights treaty bodies on HIV and AIDS, provides a normative framework to guide State actions and opportunities to engage the extensive accountability mechanisms of the United Nations international human rights system. In addition, it provides civil society organizations with the language and tools to demand State action on obesity. The authors call for similar authoritative guidance for States on the application of international human rights law to obesity

Giant popliteal aneurysm presenting with foot drop

Popliteal aneurysms are the most common peripheral arterial aneurysm and occur most commonly among older men with established cardiovascular disease. Popliteal aneurysms are asymptomatic or otherwise present with intermittent claudication, pressure symptoms in the popliteal fossa, distal embolization, and, rarely, rupture. We present a patient with a remarkably large popliteal aneurysm of 10 cm presenting as a popliteal swelling with foot drop and no signs of limb ischemia. According to our literature search, it is the largest reported popliteal aneurysm, and its corresponding symptoms are unusual. The diagnostic workup and treatment are presented