Consumer Satisfaction with Telerehabilitation Service Provision of Alternative Computer Access and Augmentative and Alternative Communication

Telerehabilitation (TR) services for assistive technology evaluation and training have the potential to reduce travel demands for consumers and assistive technology professionals while allowing evaluation in more familiar, salient environments for the consumer. Sixty-five consumers received TR services for augmentative and alternative communication or alternative computer access, and consumer satisfaction was compared with twenty-eight consumers who received exclusively in-person services. TR recipients rated their TR services at a median of 6 on a 6-point Likert scale TR satisfaction questionnaire, although individual responses did indicate room for improvement in the technology. Overall satisfaction with AT services was rated highly by both in-person (100% satisfaction) and TR (99% satisfaction) service recipients

Multi-Character Field Recognition for Arabic and Chinese Handwriting

Two methods, Symbolic Indirect Correlation (SIC) and Style Constrained Classification (SCC), are proposed for recognizing handwritten Arabic and Chinese words and phrases. SIC reassembles variable-length segments of an unknown query that match similar segments of labeled reference words. Recognition is based on the correspondence between the order of the feature vectors and of the lexical transcript in both the query and the references. SIC implicitly incorporates language context in the form of letter n-grams. SCC is based on the notion that the style (distortion or noise) of a character is a good predictor of the distortions arising in other characters, even of a different class, from the same source. It is adaptive in the sense that with a long-enough field, its accuracy converges to that of a style-specific classifier trained on the writer of the unknown query. Neither SIC nor SCC requires the query words to appear among the references

Multi-Character Field Recognition for Arabic and Chinese Handwriting

Two methods, Symbolic Indirect Correlation (SIC) and Style Constrained Classification (SCC), are proposed for recognizing handwritten Arabic and Chinese words and phrases. SIC reassembles variable-length segments of an unknown query that match similar segments of labeled reference words. Recognition is based on the correspondence between the order of the feature vectors and of the lexical transcript in both the query and the references. SIC implicitly incorporates language context in the form of letter n-grams. SCC is based on the notion that the style (distortion or noise) of a character is a good predictor of the distortions arising in other characters, even of a different class, from the same source. It is adaptive in the sense that with a long-enough field, its accuracy converges to that of a style-specific classifier trained on the writer of the unknown query. Neither SIC nor SCC requires the query words to appear among the references

Inherently fluorescent polyaniline nanoparticles in a dynamic landscape

In this paper we report for the first time on the emissive behavior of two polyaniline (PANI) nanoparticle systems produced via oxidative chemical polymerization in the presence of either poly(vinyl alcohol)(PVA) or chitosan as polymeric stabilizers in water. The emission from PANI nanoparticles is irreversibly quenched by an increase of pH of the suspending medium from acid to neutral (chitosan–PANI) or alkaline (PVA–PANI). Conversely, PANI nanorods synthesized in the same conditions of the above, but in presence of poly(N-vinyl pyrrolidone), is not emissive at any pH. The role of the polymeric surfactant as a soft template is key in controlling the morphology and the properties of the obtained PANI dispersions. FTIR, UV–Vis absorption and photoluminescence excitation (PLE) spectra studies suggest that the emissive properties are related to the establishment of strong, non-covalent interactions between nanoscalar PANI particles and the polymeric surfactant at the pH of synthesis. Morphology examination of the three systems, by both dynamic light scattering (DLS) and Transmission Electron Microscopy (TEM), reveal that photoluminescence is associated to the presence of a genuinely 3D nanoscalar morphology, together with an ordered disposition of PANI chains into aligned crystal planes. Concomitant to the irreversible quenching of the emission signal with increasing pH, there is an evolution of the morphology leading to particle coalescence, coarsening and ultimately phase-separation, with consequent modification of PANI–polymeric surfactant interactions, PANI chains supra-molecular organization and optical properties of the PANI nanoparticles dispersion

Evidence of destabilization of the human thymidylate synthase (hTS) dimeric structure induced by the interface mutation Q62R

In human cells, thymidylate synthase (TS) provides the only source of 2\u2019-deoxythymidyne-5\u2019-monophosphate (dTMP), which is required for DNA biosynthesis. Because of its pivotal role, human TS (hTS) represents a validated target for anticancer chemotherapy. Nonetheless, the efficacy of drugs blocking the hTS active site has limitations due to the onset of resistance in cancer cells, requiring the identification of new strategies to effectively inhibit this enzyme. Human TS works as an obligate homodimer, making the inter-subunit interface an attractive targetable area. Here, we report the design and investigation of a new hTS variant, in which Gln62, located at the dimer interface, has been replaced by arginine in order to destabilize the enzyme quaternary assembly. The hTS Q62R variant has been characterized though kinetic assay, thermal denaturation analysis and X-ray crystallography. Our results provide evidence that hTS Q62R has a reduced melting temperature. The effective destabilization of the TS quaternary structure is also confirmed by structural analysis, showing that the introduced mutation induces a slight aperture of the hTS dimer. The generation of hTS variants having a more accessible interface area can facilitate the screening of interface-targeting molecules, providing key information for the rational design of innovative hTS interface inhibitors

Floral biology, pollination vectors and breeding system of Zieria granulata (Rutaceae), an endangered shrub endemic to eastern Australia

Context: Understanding the factors that influence viable-seed production is crucial in the conservation of threatened plant species, yet these factors are often poorly understood. Aims: We investigated the reproductive biology of Zieria granulata C.Moore ex Benth., an endangered Australian endemic with a limited distribution, with the intent of improving conservation and restoration outcomes. Methods: Components of floral biology, including floral ontogeny and nectar production, were quantified to determine the pollination syndrome and the likely breeding system. Flower-visitor surveys (using both digital video recordings and human observations), a manipulative wind-pollination experiment and hand-pollination experiments were conducted to investigate pollination vectors and confirm the breeding system. Key results: Z. granulata flowers were small, white, protandrous and produced highly ornamented pollen grains and small quantities of nectar; these characteristics suggest that the species fits the general entomophily syndrome. All floral visitors were arthropod species and of the 72 visitors observed, predominantly from the Dipteran and Hymenopteran families, 18 could be regarded as potential pollinators. Failure of simulated wind gusts (40 km h-1) to transport pollen ≥5 cm indicated that anemophily is unlikely for this species. Autonomous and manipulative selfing did not result in viable seed set, indicating that this is an obligate outcrossing species. However, fruit and viable-seed production was highly variable within and among some other treatments. Pre-dispersal seed predation was recorded at all study sites. Conclusions: Pre-dispersal seed predation was recorded at all study sites and is a likely factor inhibiting viable-seed production. Implications: This knowledge will be used to improve seed yield for collections used for ex situ conservation and restoration programs for the endangered Z. granulata

Usando sistemas dedicados para computación paralela de propósito general

Los sistemas diseñados para resolver problemas específicos como los procesadores gráficos(GPU), tienen características (bajo precio en relación a su potencia de cálculo, gran paralelismo, optimización para cálculos en coma flotante) muy atractivas para su uso en aplicaciones de propósito general, en problemas relacionados al ámbito científico, de simulación, ingeniería, entre otros. Esto llevó al desarrollo de herramientas y técnicas para facilitar su utilización y transformarlos en una alternativa válida y casera para resolver la mayor cantidad de problemas. En este trabajo se presentan las características básicas de las GPU y las distintas líneas de trabajo a seguir. Estas líneas tienen en común la consideración de la GPU como computadora masivamente paralela. Los problemas a tratar están relacionados a las Redes de Computadoras y las Bases de Datos.Eje: Procesamiento distribuido y paraleloRed de Universidades con Carreras en Informática (RedUNCI

Testing limits to airflow perturbation device (APD) measurements

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