12,022 research outputs found
A multiplexed single electron transistor for application in scalable solid-state quantum computing
Single Electron Transistors (SETs) are nanoscale electrometers of
unprecedented sensitivity, and as such have been proposed as read-out devices
in a number of quantum computer architectures. We show that the functionality
of a standard SET can be multiplexed so as to operate as both read-out device
and control gate for a solid-state qubit. Multiplexing in this way may be
critical in lowering overall gate densities in scalable quantum computer
architectures.Comment: 3 pages 3 figure
Analysis and Geometric Optimization of Single Electron Transistors for Read-Out in Solid-State Quantum Computing
The single electron transistor (SET) offers unparalled opportunities as a
nano-scale electrometer, capable of measuring sub-electron charge variations.
SETs have been proposed for read-out schema in solid-state quantum computing
where quantum information processing outcomes depend on the location of a
single electron on nearby quantum dots. In this paper we investigate various
geometries of a SET in order to maximize the device's sensitivity to charge
transfer between quantum dots. Through the use of finite element modeling we
model the materials and geometries of an Al/Al2O3 SET measuring the state of
quantum dots in the Si substrate beneath. The investigation is motivated by the
quest to build a scalable quantum computer, though the methodology used is
primarily that of circuit theory. As such we provide useful techniques for any
electronic device operating at the classical/quantum interface.Comment: 13 pages, 17 figure
Scheme for direct measurement of a general two-qubit Hamiltonian
The construction of two-qubit gates appropriate for universal quantum
computation is of enormous importance to quantum information processing.
Building such gates is dependent on accurate knowledge of the interaction
dynamics between two qubit systems. This letter will present a systematic
method for reconstructing the full two-qubit interaction Hamiltonian through
experimental measures of concurrence. This not only gives a convenient method
for constructing two qubit quantum gates, but can also be used to
experimentally determine various Hamiltonian parameters in physical systems. We
show explicitly how this method can be employed to determine the first and
second order spin-orbit corrections to the exchange coupling in quantum dots.Comment: 4 Pages, 1 Figur
Eigenvector Approximation Leading to Exponential Speedup of Quantum Eigenvalue Calculation
We present an efficient method for preparing the initial state required by
the eigenvalue approximation quantum algorithm of Abrams and Lloyd. Our method
can be applied when solving continuous Hermitian eigenproblems, e.g., the
Schroedinger equation, on a discrete grid. We start with a classically obtained
eigenvector for a problem discretized on a coarse grid, and we efficiently
construct, quantum mechanically, an approximation of the same eigenvector on a
fine grid. We use this approximation as the initial state for the eigenvalue
estimation algorithm, and show the relationship between its success probability
and the size of the coarse grid.Comment: 4 page
A quantum algorithm providing exponential speed increase for finding eigenvalues and eigenvectors
We describe a new polynomial time quantum algorithm that uses the quantum
fast fourier transform to find eigenvalues and eigenvectors of a Hamiltonian
operator, and that can be applied in cases (commonly found in ab initio physics
and chemistry problems) for which all known classical algorithms require
exponential time. Applications of the algorithm to specific problems are
considered, and we find that classically intractable and interesting problems
from atomic physics may be solved with between 50 and 100 quantum bits.Comment: 10 page
A quantum-mechanical Maxwell's demon
A Maxwell's demon is a device that gets information and trades it in for
thermodynamic advantage, in apparent (but not actual) contradiction to the
second law of thermodynamics. Quantum-mechanical versions of Maxwell's demon
exhibit features that classical versions do not: in particular, a device that
gets information about a quantum system disturbs it in the process. In
addition, the information produced by quantum measurement acts as an additional
source of thermodynamic inefficiency. This paper investigates the properties of
quantum-mechanical Maxwell's demons, and proposes experimentally realizable
models of such devices.Comment: 13 pages, Te
The Oral-Vascular-Pulmonary Infection Route:a Pathogenic Mechanism Linking Oral Health Status to Acute and Post-Acute COVID-19
Purpose of Review: In recent years, much attention has focused on the role of poor oral health in the development or worsening of systemic diseases, including COVID-19. The mouth is an important site of cellular infection early in the disease course of COVID-19. We review how oral pathology, and specifically viral infection within the oral cavity, may mediate the disease severity and duration of COVID-19. In particular, the previously reported model of SARS-CoV-2 vascular delivery from the mouth to the lungs via the bloodstream is revisited.Recent Findings: We previously proposed that an oral-vascular-pulmonary route of infection could facilitate severe lung disease in COVID-19. This pathway could also explain the vital link between periodontitis and COVID-19 severity, including higher mortality risk. This model of pathogenesis is reconsidered in light of recent findings regarding the involvement of the mouth as a viral reservoir, and pathological processes in the blood, pulmonary vasculature, and elsewhere in the body. Oral dysbiosis in COVID-19 and the effect of oral hygiene in mitigating disease severity are discussed. The evidence for viral persistence in the mouth and intravascular viral passage from the mouth to the rest of the body via blood is also discussed in the context of post-acute COVID (long COVID).Summary: High viral load in the mouth and poor oral health status are associated with COVID-19 disease severity, increasing the risk of death. Pathophysiological links between viral activity in the mouth, oral health status, and disease outcome in the lungs and blood provide a rationale for further evaluation of the oral-vascular-systemic pathway in patients with acute COVID-19 and long COVID. The potential benefits of oral hygiene protocols and periodontal procedures in COVID-19 also warrant further investigation
The Oral-Vascular-Pulmonary Infection Route:a Pathogenic Mechanism Linking Oral Health Status to Acute and Post-Acute COVID-19
Purpose of Review: In recent years, much attention has focused on the role of poor oral health in the development or worsening of systemic diseases, including COVID-19. The mouth is an important site of cellular infection early in the disease course of COVID-19. We review how oral pathology, and specifically viral infection within the oral cavity, may mediate the disease severity and duration of COVID-19. In particular, the previously reported model of SARS-CoV-2 vascular delivery from the mouth to the lungs via the bloodstream is revisited.Recent Findings: We previously proposed that an oral-vascular-pulmonary route of infection could facilitate severe lung disease in COVID-19. This pathway could also explain the vital link between periodontitis and COVID-19 severity, including higher mortality risk. This model of pathogenesis is reconsidered in light of recent findings regarding the involvement of the mouth as a viral reservoir, and pathological processes in the blood, pulmonary vasculature, and elsewhere in the body. Oral dysbiosis in COVID-19 and the effect of oral hygiene in mitigating disease severity are discussed. The evidence for viral persistence in the mouth and intravascular viral passage from the mouth to the rest of the body via blood is also discussed in the context of post-acute COVID (long COVID).Summary: High viral load in the mouth and poor oral health status are associated with COVID-19 disease severity, increasing the risk of death. Pathophysiological links between viral activity in the mouth, oral health status, and disease outcome in the lungs and blood provide a rationale for further evaluation of the oral-vascular-systemic pathway in patients with acute COVID-19 and long COVID. The potential benefits of oral hygiene protocols and periodontal procedures in COVID-19 also warrant further investigation
Analog quantum error correction
Quantum error-correction routines are developed for continuous quantum
variables such as position and momentum. The result of such analog quantum
error correction is the construction of composite continuous quantum variables
that are largely immune to the effects of noise and decoherence.Comment: Ten pages, Te
Naturopaths’ mobilisation of knowledge and information in clinical practice: an international cross-sectional survey
Background
The contemporary evidence-based practice model acknowledges the importance of patient preferences and clinician experience when applying evidence within a clinical setting. Knowledge mobilisation (KM) acknowledges the complexities of knowledge translation by recognising and respecting diversity in types of knowledge and how such diversity can influence health care and health care choices. While there has been considerable discussion on KM in health care, it has received little attention in the field of naturopathy. Despite naturopathy’s widespread international use, it is unclear how naturopathic practitioners (NPs) use and share knowledge and information in clinical practice. This study examines the mobilisation of knowledge amongst NPs internationally.
Methods
Online, international, cross-sectional survey of a self-selected sample of NPs from any country, that were either currently in clinical practice or had been in practice within the previous 12 months. The survey was administered in five languages (English, French, Portuguese, Spanish, German). Descriptive statistics were prepared for all survey items.
Results
The survey was completed by 478 NPs who reported using an average of seven (median = 7, SD = 2.6) information sources to inform patient care. NPs also drew on knowledge gained through patients sharing their perspectives of living with their health condition (Always/Most of the time: 89.3%). They mostly sought knowledge about how a treatment might benefit a patient, as well as knowledge about treatment safety and a better understanding of a patient’s health condition. NPs frequently reported sharing knowledge developed through consideration of the patient’s unique needs (83.3%), and primarily shared knowledge by producing information for the public (72.6%) and for patients (72.2%).
Conclusions
Based on these findings, it may be argued that NPs practice knowledge mobilisation; employing multiple forms and sources of knowledge, and mobilising knowledge to - as well as from - others. Due to their active engagement in patient and community education, NPs also may be considered knowledge brokers. In the context of the growing understanding of the complexities of knowledge translation and mobilisation in contemporary health care – and particularly within the context of implementation science – this study provides novel insights into an under-researched element of health services accessed by the communit
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