On the dilemma between percolation processes and fluctuating pairs as the origin of the enhanced conductivity above the superconducting transition in cuprates

The confrontation between percolation processes and superconducting fluctuations to account for the observed enhanced in-plane electrical conductivity above but near $T_c$ in cuprates is revisited. The cuprates studied here, La$_{1.85}$Sr$_{0.15}$CuO$_4$, Bi$_2$Sr$_2$CaCu$_2$O$_{8+\delta}$, and Tl$_2$Ba$_2$Ca$_2$Cu$_3$O$_{10}$, have a different number of superconducting CuO$_2$ layers per unit-cell length and different Josephson coupling between them, and are optimally-doped to minimize $T_c$-inhomogeneities. The excellent chemical and structural quality of these samples also contribute to minimize the effect of extrinsic $T_c$-inhomogeneities, a crucial aspect when analyzing the possible presence of intrinsic percolative processes. Our analyses also cover the so-called high reduced-temperature region, up to the resistivity rounding onset $\varepsilon_{onset}$. By using the simplest form of the effective-medium theory, we show that possible emergent percolation processes alone cannot account for the measured enhanced conductivity. In contrast, these measurements can be quantitatively explained using the Gaussian-Ginzburg-Landau (GGL) approach for the effect of superconducting fluctuations in layered superconductors, extended to $\varepsilon_{onset}$ by including a total energy cutoff, which takes into account the limits imposed by the Heisenberg uncertainty principle to the shrinkage of the superconducting wavefunction. Our analysis confirms the adequacy of this cutoff, and that the effective periodicity length is controlled by the relative Josephson coupling between superconducting layers. These conclusions are reinforced by analyzing one of the recent works that allegedly discards the superconducting fluctuations scenario while supporting a percolative scenario for the enhanced conductivity above $T_c$ in cuprates.Comment: 13 pages, 7 figure

Enhancement of the critical current by surface irregularities in Fe-based superconductors

The critical current $I_c$ of single crystals of the iron pnictide superconductor BaFe$_2$(As$_{1-x}$P$_x$)$_2$, has been studied through measurements of magnetic hysteresis cycles. We show that the introduction of surface irregularities in the $\mu$m scale significantly increase $I_c$, primarily near the irreversibility magnetic field $H_{irr}$, where the surface currents are the main contribution to $I_c$. Such an increase is consistent with a theoretical estimate for the maximum non-dissipative current that a rough surface can sustain, based on Mathieu-Simon continuum theory for the vortex state.Comment: 24 pages including 5 pages of supplementary materia

Microfluidic fabrication of gadolinium-doped hydroxyapatite for theragnostic applications

Among the several possible uses of nanoparticulated systems in biomedicine, their potential as theragnostic agents has received significant interest in recent times. In this work, we have taken advantage of the medical applications of Gadolinium as a contrast agent with the versatility and huge array of possibilities that microfluidics can help to create doped Hydroxyapatite nanoparticles with magnetic properties in an efficient and functional way. First, with the help of Computational Fluid Dynamics (CFD), we performed a complete and precise study of all the elements and phases of our device to guarantee that our microfluidic system worked in the laminar regime and was not affected by the presence of nanoparticles through the flow requisite that is essential to guarantee homogeneous diffusion between the elements or phases in play. Then the obtained biomaterials were physiochemically characterized by means of XRD, FE-SEM, EDX, confocal Raman microscopy, and FT-IR, confirming the successful incorporation of the lanthanide element Gadolinium in part of the Ca (II) binding sites. Finally, the magnetic characterization confirmed the paramagnetic behaviour of the nanoparticles, demonstrating that, with a simple and automatized system, it is possible to obtain advanced nanomaterials that can offer a promising and innovative solution in theragnostic applications.M.S.: R.R. and J.M.R. thank Xunta de Galicia for support (ED431B 2022/36), R.R. is granted by the Program for the requalification, international mobility, and attraction of talent in the Spanish university system, modality Margarita Salas. J.M. and I.F.L. acknowledge support from the Spanish Agencia Estatal de Investigación (project PID2019-104296GB-I00), and I.F.L. from Xunta de Galicia (grant ED481A-2020/149)

Prospective comparative multi-centre study on imported Plasmodium ovale wallikeri and Plasmodium ovale curtisi infections

BACKGROUND: Few previous retrospective studies suggest that Plasmodium ovale wallikeri seems to have a longer latency period and produces deeper thrombocytopaenia than Plasmodium ovale curtisi. Prospective studies were warranted to better assess interspecies differences. METHODS: Patients with imported P. ovale spp. infection diagnosed by thick or thin film, rapid diagnostic test (RDT) or polymerase chain reaction (PCR) were recruited between March 2014 and May 2017. All were confirmed by DNA isolation and classified as P. o. curtisi or P. o. wallikeri using partial sequencing of the ssrRNA gene. Epidemiological, analytical and clinical differences were analysed by statistical methods. RESULTS: A total of 79 samples (35 P. o. curtisi and 44 P. o. wallikeri) were correctly genotyped. Males predominate in wallikeri group (72.7%), whereas were 48.6% in curtisi group. Conversely, 74.3% of curtisi group were from patients of African ethnicity, whilst 52.3% of Caucasians were infected by P. o. wallikeri. After performing a multivariate analysis, more thrombocytopaenic patients (p = 0.022), a lower number of platelets (p = 0.015), a higher INR value (p = 0.041), and shorter latency in Caucasians (p = 0.034) were significantly seen in P. o. wallikeri. RDT sensitivity was 26.1% in P. o. curtisi and 42.4% in P. o. wallikeri. Nearly 20% of both species were diagnosed only by PCR. Total bilirubin over 3 mg/dL was found in three wallikeri cases. Two patients with curtisi infection had haemoglobin under 7 g/dL, one of them also with icterus. A wallikeri patient suffered from haemophagocytosis. Chemoprophylaxis failed in 14.8% and 35% of curtisi and wallikeri patients, respectively. All treated patients with various anti-malarials which included artesunate recovered. Diabetes mellitus was described in 5 patients (6.32%), 4 patients of wallikeri group and 1 curtisi. CONCLUSIONS: Imported P. o. wallikeri infection may be more frequent in males and Caucasians. Malaria caused by P. o. wallikeri produces more thrombocytopaenia, a higher INR and shorter latency in Caucasians and suggests a more pathogenic species. Severe cases can be seen in both species. Chemoprophylaxis seems less effective in P. ovale spp. infection than in P. falciparum, but any anti-malarial drug is effective as initial treatment. Diabetes mellitus could be a risk factor for P. ovale spp. infection

Materials with fungi-bioinspired surface for efficient binding and fungi-sensitive release of antifungal agents.

Materials with fungi-bioinspired surface have been designed to host ergosterol-binding polyene antibiotics and to release them via a competitive mechanism only when fungi are present in the medium. Silicone rubber (SR) surfaces were endowed with selective loading and fungi-triggered release of polyene antifungal agents by means of a two-step functionalization that involved the grafting of glycidyl methacrylate (GMA) via a gamma-ray preirradiation method (9-21.3% wt grafting) and the subsequent immobilization of ergosterol (3.9-116.8 mg/g) to the epoxy groups of polyGMA. The functionalized materials were characterized using FTIR and Raman spectroscopy, thermogravimetric analysis (TGA), and fluorescence, scanning electron microscopy (SEM), and atomic force microscopy (AFM) image analyses. Specific interactions between natamycin or nystatin and ergosterol endowed SR with ability to take up these polyene drugs, while immobilization of ergosterol did not modify the loading of antifungal drugs that did not interact in vivo with ergosterol (e.g., miconazole). In a buffer medium, polyene-loaded ergosterol-immobilized slabs efficiently retained the drug (<10% released at day 14), while in the presence of ergosterol-containing liposomes that mimic fungi membranes the release rate was 10-to-15-fold enhanced due to a competitive displacement of the drug from the ergosterol-immobilized slab to the ergosterol-containing liposomes. Release in the presence of cholesterol liposomes was slower due to a weaker interaction with polyene agents. The fungi-responsive release was demonstrated for both polyene drugs tested and for slabs prepared with a wide range of amounts of immobilized GMA and ergosterol, demonstrating the robustness of the approach. Nystatin-loaded functionalized slabs were challenged with Candida albicans and showed improved capability to inhibit biofilm formation compared to nystatin-soaked pristine SR, confirming the performance of the bioinspired materials