RICORS2040 : The need for collaborative research in chronic kidney disease

Chronic kidney disease (CKD) is a silent and poorly known killer. The current concept of CKD is relatively young and uptake by the public, physicians and health authorities is not widespread. Physicians still confuse CKD with chronic kidney insufficiency or failure. For the wider public and health authorities, CKD evokes kidney replacement therapy (KRT). In Spain, the prevalence of KRT is 0.13%. Thus health authorities may consider CKD a non-issue: very few persons eventually need KRT and, for those in whom kidneys fail, the problem is 'solved' by dialysis or kidney transplantation. However, KRT is the tip of the iceberg in the burden of CKD. The main burden of CKD is accelerated ageing and premature death. The cut-off points for kidney function and kidney damage indexes that define CKD also mark an increased risk for all-cause premature death. CKD is the most prevalent risk factor for lethal coronavirus disease 2019 (COVID-19) and the factor that most increases the risk of death in COVID-19, after old age. Men and women undergoing KRT still have an annual mortality that is 10- to 100-fold higher than similar-age peers, and life expectancy is shortened by ~40 years for young persons on dialysis and by 15 years for young persons with a functioning kidney graft. CKD is expected to become the fifth greatest global cause of death by 2040 and the second greatest cause of death in Spain before the end of the century, a time when one in four Spaniards will have CKD. However, by 2022, CKD will become the only top-15 global predicted cause of death that is not supported by a dedicated well-funded Centres for Biomedical Research (CIBER) network structure in Spain. Realizing the underestimation of the CKD burden of disease by health authorities, the Decade of the Kidney initiative for 2020-2030 was launched by the American Association of Kidney Patients and the European Kidney Health Alliance. Leading Spanish kidney researchers grouped in the kidney collaborative research network Red de Investigación Renal have now applied for the Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS) call for collaborative research in Spain with the support of the Spanish Society of Nephrology, Federación Nacional de Asociaciones para la Lucha Contra las Enfermedades del Riñón and ONT: RICORS2040 aims to prevent the dire predictions for the global 2040 burden of CKD from becoming true

Weak-polynomial convergence on spaces lp and Lp

This paper is concerned with the study of the set P-1 (0), when P varies over all orthogonally additive polynomials on l(p) and L (p) spaces. We apply our results to obtain characterizations of the weak-polynomial topologies associated to this class of polynomials

Aplicación de la Tomografía Axial Computerizada de Rayos X al estudio de materiales rocosos

Se han sometido muestras de la dolomía de Laspra (una de las rocas utilizadas en la construcción de la Catedral de Oviedo) a ciclos de hielo-deshielo con el fin de estudiar la aplicabilidad de la tomografía axial computerizada de rayos X al estudio de las características texturales de la roca, así como a la evaluación de los daflos producidos; las muestras han sido observadas en superficie por medio de una lupa binocular tras cada ciclo, detectándose la aparición de fisuras en el cuarto ciclo. La tomografía de rayos X (TAC) ha suministrado una información precisa del desarrollo de la fisuración en el interior de las muestras, pudiendo observarse que el mismo está asociado al límite entre dos zonas texturalmente diferentes. Debido al carácter "no destructivo" de la tomografía de rayos X, se comprueba su aplicabilidad al estudio del interior de los materiales rocosos, tanto para la detección de fisuras, como para conocer su distribución y desarrollo en relación a la textura de la roc

Compound heterozygosity for PTPN11 variants in a subject with Noonan syndrome provides insights into the mechanism of SHP2-related disorders

The RASopathies are a family of clinically related disorders caused by mutations affecting genes participating in the RAS-MAPK signaling cascade. Among them, Noonan syndrome (NS) and Noonan syndrome with multiple lentigines (NSML) are allelic conditions principally associated with dominant mutations in PTPN11, which encodes the nonreceptor SH2 domain-containing protein tyrosine phosphatase SHP2. Individual PTPN11 mutations are specific to each syndrome and have opposite consequences on catalysis, but all favor SHP2's interaction with signaling partners. Here, we report on a subject with NS harboring biallelic variants in PTPN11. While the former (p.Leu261Phe) had previously been reported in NS, the latter (p.Thr357Met) is a novel change impairing catalysis. Members of the family carrying p.Thr357Met, however, did not show any obvious feature fitting NSML or within the RASopathy phenotypic spectrum. A major impact of this change on transcript processing and protein stability was excluded. These findings further support the view that NSML cannot be ascribed merely to impaired SHP2's catalytic activity and suggest that PTPN11 mutations causing this condition act through an alternative dominant mechanism

On the multilinear Hausdorff problem of moments

Given a multi-index sequence necessary and sufficient conditions are given for the existence of a regular Borel polymeasure on the unit interval such that . This problem will be called the weak multilinear Hausdorff problemof moments for . Comparison with classical results will allow us to relate the weak multilinear Hausdorff problem with the multivariate Hausdorff problem. A solution to the strong multilinear Hausdorff problem of moments will be provided by exhibiting necessary and sufficient conditions for the existence of a Radon measure on such that where is the -linear moment functional on the space of continuous functions on the unit interval defined by the sequence . Finally the previous results will be used to provide a characterization of a class of weakly harmonizable stochastic processes with bimeasures supported on compact sets