2 research outputs found
Synthesis of sphingoid bases by transition metal-catalyzed reactions
Les bases esfingoides, aminoalcohols de cadena llarga, sovint es troben enllaçades a un
Ă cid gras formant les anomenades ceramides. Aquestes ceramides constitueixen la part
hidrofòbica essencial dels glicolĂpids, com -GalCer, iGB3 o KRN7000, que es troben a
la membrana de les cèl·lules eucariotes i que participen en processos fisiològics
importants involucrats en la prevenciĂł de malalties com infeccions virals, infeccions
microbianes, cà ncer, diabetis, malalties de Parkinson i Alzheimer entre d’altres. Dins el
marc de la necessitat de desenvolupar noves metodologies de sĂntesi d’aquestes bases
esfingoides, en la present tesi doctoral s’han desenvolupat tres nous mètodes sintètics,
sent els mètodes estereoselectius més eficients fins el moment, basats en reaccions
catalitzades per metalls de transiciĂł.Glycosphingolipids are commonly found in eukaryotic cell membranes, plasma
membranes and some intracellular organelles. They play a critical role in
communication as shown promising bioactivities against diverse pathologies.
Glycosphingolipids are constituted by a mono- or oligosaccharide moiety link to the
ceramide part, which is a sphingoid base link to a fatty acid. Due to its importance, it is
necessary to develop new methodologies to synthesize them. In this thesis, we
developed three new synthetic methods based on stereoselective processes catalyzed by
transition metal reactions