Seismicity Enhances Macrodispersion in Finite Porous and Fractured Domains: A Pore-Scale Perspective

Understanding the effects of oscillating flow field induced by seismicity on the transport process is vital for predicting the fate and transport of solute in many dynamic environments. However, there is prominent discrepancy in arguing with the response of dispersion to the oscillating flow field (i.e., the longitudinal dispersion coefficient would decrease, increase, or maintain unchanged). To unravel the underpinning physics about this controversial response, we simulated two-hundred twenty pore-scale numerical experiments for the seismicity-induced oscillating flow field and associated solute transport in the idealized finite porous (i.e., fluidic plate) and fractured (i.e., parallel plates) domains. The numerically obtained breakthrough curves were fitted to the macroscopic advection-dispersion equation to retrieve the mean velocity and apparent macrodispersion coefficient (DL). We found that DL increases to its maxima when the oscillating flow field resonates with the finite systems, that is, the period (T) of the oscillating flow field or the seismic wave approaches the pore volume (τ) of a finite domain. The resonant effects diminish and DL barely changes when T is much larger or smaller than τ. Moreover, the degree of enhancement in DL increases exponentially with the amplitude of the seismic force. Fundamental understanding of the response of macrodispersion to the oscillating flow field adds value in predicting the fate of solute in transient flow systems via the advection-dispersion equation

Myrica rubra Extracts Protect the Liver from CCl4-Induced Damage

The relationship between the expression of mitochondrial voltage-dependent anion channels (VDACs) and the protective effects of Myrica rubra Sieb. Et Zucc fruit extract (MCE) against carbon tetrachloride (CCl4)-induced liver damage was investigated. Pretreatment with 50 mg kg−1, 150 mg kg−1 or 450 mg kg−1 MCE significantly blocked the CCl4-induced increase in both serum aspartate aminotransferase (sAST) and serum alanine aminotransferase (sALT) levels in mice (P < .05 or .01 versus CCl4 group). Ultrastructural observations of decreased nuclear condensation, ameliorated mitochondrial fragmentation of the cristae and less lipid deposition by an electron microscope confirmed the hepatoprotection. The mitochondrial membrane potential dropped from −191.94 ± 8.84 mV to −132.06 ± 12.26 mV (P < .01) after the mice had been treated with CCl4. MCE attenuated CCl4-induced mitochondrial membrane potential dissipation in a dose-dependent manner. At a dose of 150 or 450 mg kg−1 of MCE, the mitochondrial membrane potentials were restored (P < .05). Pretreatment with MCE also prevented the elevation of intra-mitochondrial free calcium as observed in the liver of the CCl4-insulted mice (P < .01 versus CCl4 group). In addition, MCE treatment (50–450 mg kg−1) significantly increased both transcription and translation of VDAC inhibited by CCl4. The above data suggest that MCE mitigates the damage to liver mitochondria induced by CCl4, possibly through the regulation of mitochondrial VDAC, one of the most important proteins in the mitochondrial outer membrane

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin

Measuring the Intermediate Goods&rsquo; External Dependency on the Global Value Chain: A Case Study of China

In the face of the anti-globalization trend and the shrinking of the global value chain, ensuring the safety of the global layout of the industrial chain and the sustainability of each country&rsquo;s internal intermediate product production cycle has become an important new development strategy for all countries. The sustainability of the internal and external cycles of production systems is closely related to global value chains. Based on the world input-output model, we define the trade pattern of intermediate goods in various countries from the perspective of trade intermediary attributes, and propose two indicators by which to measure the dependence of China on the global value chain in the process of &ldquo;dual circulation&rdquo; development: the degree of vertical specialization (VSD) and the import share of domestic total consumption (IMS); China&rsquo;s super-large market leads to low values of both VSD and IMS. China&rsquo;s high-tech industry has the highest degree of external dependence in the process of participating in dual circulation, and there has been a fluctuation cycle since 2009. The external dependence of different industries shows heterogeneity

Structural Characteristics and Evolutionary Drivers of Global Virtual Water Trade Networks: A Stochastic Actor-Oriented Model for 2000–2015

The globalization of trade has caused tremendous pressure on water resources globally, and a virtual water trade provides a new perspective on global freshwater sharing and water sustainability. No study has yet explored the structural characteristics and drivers of the evolution of global virtual water trade networks from a network structure evolution perspective. This paper aims to fill this critical gap by developing a research framework to explore how endogenous network structures and external factors have influenced the evolution of virtual water trade networks. We constructed virtual water trade networks for 62 countries worldwide from 2000 to 2015 and used an innovative combination of multi-regional input–output data and stochastic actor-oriented models for analytical purposes. Our results support the theoretical hypothesis of ecologically unequal exchange and trade drivers, arguing that virtual water flows from less developed countries to developed countries under global free trade and that unequal trade patterns lead to excessive consumption of virtual water in less developed countries. The results partially support the theoretical content of water endowment and traditional gravity models, finding that trade networks are expanding to farther and larger markets, confirming that national water scarcity levels do not impact the evolution of virtual water trade networks. Finally, we point out that meritocratic links, path dependence, reciprocity, and transmissive links have extreme explanatory power for the evolutionary development of virtual water networks

Investigation of aerodynamic effects of rotation on 6-DOF motion of flat square plate based on free flight experiments

Plate-like debris is common windborne debris in windstorms. Although the 3-degree-of-freedom (3-DOF) motion (two translational DOFs and one rotational DOF) of flat plates has been widely investigated in previous studies, the 6-DOF motion is more likely to occur in real storms. We investigate the 6-DOF motion by performing free flight experiments of a square plate with different initial orientations under uniforms flow in a wind tunnel. Two cameras are used to record the flight motion of the plate. Then the recordings are processed in an image analysis software to estimate the kinematics of the plate. We first investigate the characteristics of the rotational motion. According to the rotational characteristics, the plate trajectories are categorized into four flight patterns: flutter, tumbling, transition, and quasi-translation. Then we explore the rotational effects on the aerodynamics. We propose a hypothesis that the magnitude and direction of the rotational forces depend on the angular velocity and the relative wind velocity. We also propose a hypothesis that the rotational moment has negligible influences on the direction of the instantaneous moment. These hypotheses are supported by the experimental results. These verified hypotheses may be helpful for modelling the aerodynamics of the 6-DOF motion of flat plates

IJDM Special Issue on Microstructural Mechanics and Damage Mechanics of Materials

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