25 research outputs found

    Sport officiating recruitment, development, and retention: A call to action

    Get PDF
    The purpose of this article is to report on the outcome of a two-day consensus-building exercise amongst sport scientists and sport practitioners interested in the recruitment, development, and retention of sport officials.  Twenty participants including volunteers and paid employees affiliated with nine Ontario-based sport organizations, university researchers, and provincial government policy makers participated.  A consensus statement regarding this aspect of sport officiating and, more specifically, “What do we know?”, “What don’t we know?”, and “Where does the research need to go from here?” is presented.  A willingness to consider and embrace these ideas may be critical in moving sport officiating from being an understudied and undervalued segment of the sport system to receiving the attention and respect it deserves going forward

    Comparison of immune response generated against Japanese encephalitis virus envelope protein expressed by DNA vaccines under macrophage associated versus ubiquitous expression promoters

    Get PDF
    <p>Abstract</p> <p>Background</p> <p>Japanese encephalitis virus (JEV) is the leading cause of viral encephalitis, with ~50,000 cases reported annually worldwide. Vaccination is the only measure for prevention. Recombinant vaccines are an efficient and safe alternative for formalin inactivated or live attenuated vaccines. Nowadays, incorporation of molecular adjuvants has been the main strategy for melioration of vaccines. Our attempt of immunomodulation is based on targeting antigen presenting cells (APC) "majorly macrophages" by using macrosialin promoter. We have compared the immune response of the constructed plasmids expressing JEV envelope (E) protein under the control of aforesaid promoter and cytomegalovirus (CMV) immediate early promoter in mouse model. Protection of immunized mice from lethal challenge with JEV was also studied.</p> <p>Results</p> <p>The E protein was successfully expressed in the macrophage cell line and was detected using immunofluorescence assay (IFA) and Western blotting. APC expressing promoter showed comparable expression to CMV promoter. Immunization of mice with either of the plasmids exhibited induction of variable JEV neutralizing antibody titres and provided protection from challenge with a lethal dose of JEV. Immune splenocytes showed proliferative response after stimulation with the JEV antigen (Ag), however, it was higher for CMV promoter. The magnitude of immunity provided by APC dominant promoter was non-significantly lower in comparison to CMV promoter. More importantly, immune response directed by APC promoter was skewed towards Th1 type in comparison to CMV promoter, this was evaluated by cytokine secretion profile of immune splenocytes stimulated with JEV Ag.</p> <p>Conclusions</p> <p>Thus, our APC-expressing DNA vaccination approach induces comparable immunity in comparison to ubiquitous promoter construct. The predominant Th1 type immune responses provide opportunities to further test its potency suitable for response in antiviral or anticancer vaccines.</p

    Weaving indigenous agricultural knowledge with formal education to enhance community food security : school competition as a pedagogical space in rural Anchetty, India

    Get PDF
    In communities from the remote rural regions of Anchetty, young learners’ informal learning experiences often come through interactions with local agriculture and the environment in which they and their families work and learn. These informal learning experiences are essential to what are otherwise called ‘indigenous knowledge systems’. For primary school students in Anchetty, the ways in which they engage in learning community-based agricultural knowledge are challenged by school-based formal education processes. Using a school competition as a pedagogical strategy for integrative space, this paper supports and explores the meaning and characteristics of indigenous agricultural knowledge (IAK)

    Annual Report 2018-2019: Student Life & Development

    Get PDF
    Student Life and Development (SLD) professionals at Winona State University (WSU) deliver programs, services, and activities that support students\u27 academic achievement, social development, and well-being in the timely pursuit of their educational goals. The 2018-2019 SLD Annual Report provides information from the following departments: Admissions, Community Engagement, Conduct & Citizenship, Counseling & Wellness, Dean of Students, Health & Wellness Services, Housing & Residence Life, Inclusion & Diversity Office, Integrative Wellness, Student Activities & Leadership, TRIO Student Support Services, the Student Union, the Warrior Hub, and the Warrior Success Center.https://openriver.winona.edu/annualreportssld/1001/thumbnail.jp
    corecore