39 research outputs found
Blocking FSH induces thermogenic adipose tissue and reduces body fat
Get PDFFunctional Genomics of Systemic Disorder
Numercial Analysis of Geogrid and Plastic Drainage Plate Used in Existed Railway Alteration Project
No full textAn efficient equivalent circuit model for the EMC analysis of power/ground noise
No full text10.1109/SPI.2008.455835012th IEEE Workshop on Signal Propagation on Interconnects, SPI
Treatment and Monitoring of Venous Thromboembolism (VTE) Among Hospitalized Patients in China
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Influence of Trough Excavation Study on Deformation of Deep Foundation Pit Support Structure in Water-rich Area
No full textForced Unfolding of Coiled-Coils in Fibrinogen by Single-Molecule AFM
Get PDFFibrinogen is a blood plasma protein that, after activation by thrombin, assembles into fibrin fibers that form the elastic network of blood clots. We used atomic force microscopy to study the forced unfolding of engineered linear oligomers of fibrinogen, and we show that forced extension of the oligomers produces sawtooth patterns with a peak-to-peak length consistent with the independent unfolding of the coiled-coils in a cooperative two-state manner. In contrast with force plateaus seen for myosin coiled-coils that suggested rapid refolding of myosin, Monte Carlo simulations of fibrinogen unfolding confirm that fibrinogen refolding is negligible on experimental timescales. The distinct behavior of fibrinogen seems to be due to its topologically complex coiled-coils and an interaction between fibrinogen's αC-domains and its central region
Mild Hypoxic-Ischemic Injury in the Neonatal Rat Brain: Longitudinal Evaluation of White Matter Using Diffusion Tensor MR Imaging
No full textHeavy Metal Pollution in Topsoil and Vegetables in the Typical Mining Area Near Gannan, Jiangxi Province, China
No full textSintering characteristics and microstructure of WC-Co-VC/Cr3C2 ultrafine cemented carbides
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