Efficacy and safety of post-auricular injection of methylprednisolone sodium succinate and lidocaine in the treatment of acute tinnitus, and its effect on sleep quality

Purpose: To study the efficacy and safety of post-auricular injection of methylprednisolone sodium succinate plus lidocaine in the treatment of acute tinnitus, and its effect on sleep quality.Methods: Eighty acute tinnitus patients admitted to Nanfang Hospital, Southern Medical University, Guangzhou, China from January 2020 to June 2021, served as subjects for this retrospective analysis. The patients were equally assigned to a reference group given postauricular injection of lidocaine, and a research group treated with post-auricular injection of methylprednisolone sodium succinate in combination with lidocaine. Treatment efficacy values in the two groups of patients were determined and compared.Results: Total treatment effectiveness values in patients in the research group after one course of treatment, and at three months post-treatment, were significantly higher than the corresponding values in the reference group (p < 0.05). After treatment, the two groups had markedly improved Tinnitus Handicap Inventory (THI) scores, although patients in the research group had lower scores than those in reference group (p < 0.05). There were significant decreases in post-treatment pure tone threshold and Pittsburgh sleep quality index (PSQI) in the two groups of patients, with lower values in the research group than in the reference group (p < 0.05). There were no obvious adverse drug reactions during treatment and during 3-month follow-up period.Conclusion: Post-auricular injection of methylprednisolone sodium succinate and lidocaine effectively improved the clinical efficacy and the sleep quality of acute tinnitus patients. It is a simple and highly safe operation which merits clinical application

X-ray spectral correlations in a sample of Low-mass black hole X-ray binaries in the hard state

The power-law emission and reflection component provide valuable insights into the accretion process around a black hole. In this work, thanks to the broadband spectra coverage of \emph{the Nuclear Spectroscopic Telescope Array}, we study the spectral properties for a sample of low-mass black hole X-ray binaries (BHXRBs). We find that there is a positive correlation between the photon index $\Gamma$ and the reflection fraction $R$ (the ratio of the coronal intensity that illuminates the disk to the coronal intensity that reaches the observer), consistent with previous studies, but except for MAXI J1820+070. It is quite interesting that this source also deviates from the well-known ``V"-shaped correlation between the photon index $\Gamma$ and the X-ray luminosity log$L_{\rm X}$, when it is in the bright hard state. More specifically, the $\Lambda$-shaped correlation between $\Gamma$ and log$L_{\rm X}$ is observed, as the luminosity decreases by a factor of 3 in a narrow range from $\sim 10^{38}$ to $10^{37.5}$ $\rm erg~s^{-1}$. Furthermore, we discover a strong positive correlation between $R$ and the X-ray luminosity for BHXRBs in the hard state, which puts a constraint on the disk-corona coupling and the evolution.Comment: 18 pages, 9 figures, 3 tables, Accepted for publication in Ap

Measurement of the vertical atmospheric density profile from the X-ray Earth occultation of the Crab Nebula with Insight-HXMT

In this paper, the X-ray Earth occultation (XEO) of the Crab Nebula is investigated by using the Hard X-ray Modulation Telescope (Insight-HXMT). The pointing observation data on the 30th September, 2018 recorded by the Low Energy X-ray telescope (LE) of Insight-HXMT are selected and analyzed. The extinction lightcurves and spectra during the X-ray Earth occultation process are extracted. A forward model for the XEO lightcurve is established and the theoretical observational signal for lightcurve is predicted. The atmospheric density model is built with a scale factor to the commonly used MSIS density profile within a certain altitude range. A Bayesian data analysis method is developed for the XEO lightcurve modeling and the atmospheric density retrieval. The posterior probability distribution of the model parameters is derived through the Markov Chain Monte Carlo (MCMC) algorithm with the NRLMSISE-00 model and the NRLMSIS 2.0 model as basis functions and the best-fit density profiles are retrieved respectively. It is found that in the altitude range of 105--200 km, the retrieved density profile is 88.8% of the density of NRLMSISE-00 and 109.7% of the density of NRLMSIS 2.0 by fitting the lightcurve in the energy range of 1.0--2.5 keV based on XEOS method. In the altitude range of 95--125 km, the retrieved density profile is 81.0% of the density of NRLMSISE-00 and 92.3% of the density of NRLMSIS 2.0 by fitting the lightcurve in the energy range of 2.5--6.0 keV based on XEOS method. In the altitude range of 85--110 km, the retrieved density profile is 87.7% of the density of NRLMSISE-00 and 101.4% of the density of NRLMSIS 2.0 by fitting the lightcurve in the energy range of 6.0--10.0 keV based on XEOS method. This study demonstrates that the XEOS from the X-ray astronomical satellite Insight-HXMT can provide an approach for the study of the upper atmosphere.Comment: 31 pages, 15 figures, 5 tables, accepted for publication in Atmospheric Measurement Technique

Unraveling Controversies Over Civic Honesty Measurement: An Extended Field Replication in China

Cohn et al. (2019) conducted a wallet drop experiment in 40 countries to measure civic honesty around the globe, which has received worldwide attention but also sparked controversies over using the email response rate as the sole metric of civic honesty. Relying on the lone measurement may overlook cultural differences in behaviors that demonstrate civic honesty. To investigate this issue, we conducted an extended replication study in China, utilizing email response and wallet recovery to assess civic honesty. We found a significantly higher level of civic honesty in China, as measured by the wallet recovery rate, than reported in the original study, while email response rates remained similar. To resolve the divergent results, we introduce a cultural dimension, individualism versus collectivism, to study civic honesty across diverse cultures. We hypothesize that cultural differences in individualism and collectivism could influence how individuals prioritize actions when handling a lost wallet, such as contacting the wallet owner or safeguarding the wallet. In reanalyzing Cohn et al.\u27s data, we found that email response rates were inversely related to collectivism indices at the country level. However, our replication study in China demonstrated that the likelihood of wallet recovery was positively correlated with collectivism indicators at the provincial level. Consequently, relying solely on email response rates to gauge civic honesty in cross-country comparisons may neglect the vital individualism versus collectivism dimension. Our study not only helps reconcile the controversy surrounding Cohn et al.\u27s influential field experiment but also furnishes a fresh cultural perspective to evaluate civic honesty

Burst phase distribution of SGR J1935+2154 based on Insight-HXMT

On April 27, 2020, the soft gamma ray repeater SGR J1935+2154 entered its intense outburst episode again. Insight-HXMT carried out about one month observation of the source. A total number of 75 bursts were detected during this activity episode by Insight-HXMT, and persistent emission data were also accumulated. We report on the spin period search result and the phase distribution of burst start times and burst photon arrival times of the Insight-HXMT high energy detectors and Fermi Gamma-ray Burst Monitor (GBM). We find that the distribution of burst start times is uniform within its spin phase for both Insight-HXMT and Fermi-GBM observations, whereas the phase distribution of burst photons is related to the type of a burst's energy spectrum. The bursts with the same spectrum have different distribution characteristics in the initial and decay episodes for the activity of magnetar SGR J1935+2154.Comment: 12 pages, 9 figure

Elevated atmospheric CO2 concentration triggers redistribution of nitrogen to promote tillering in rice

Elevated atmospheric CO2 concentration (eCO2) often reduces nitrogen (N) content in rice plants and stimulates tillering. However, there is a general consensus that reduced N would constrain rice tillering. To resolve this contradiction, we investigated N distribution and transcriptomic changes in different rice plant organs after subjecting them to eCO2 and different N application rates. Our results showed that eCO2 significantly promoted rice tillers (by 0.6, 1.1, 1.7, and 2.1 tillers/plant at 0, 75, 150, and 225 kg N ha−1 N application rates, respectively) and more tillers were produced under higher N application rates, confirming that N availability constrained tillering in the early stages of growth. Although N content declined in the leaves (−11.0 to −20.7 mg g−1) and sheaths (−9.8 to −28.8 mg g−1) of rice plants exposed to eCO2, the N content of newly emerged tillers on plants exposed to eCO2 equaled or exceeded the N content of tillers produced under ambient CO2 conditions. Apparently, the redistribution of N within the plant per se was a critical adaptation strategy to the eCO2 condition. Transcriptomic analysis revealed that eCO2 induced less extensive alteration of gene expression than did N application. Most importantly, the expression levels of multiple N-related transporters and receptors such as nitrate transporter NRT2.3a/b and NRT1.1a/b were differentially regulated in leaf and shoot apical meristem, suggesting that multiple genes were involved in sensing the N signal and transporting N metabolites to adapt to eCO2. The redistribution of N in different organs could be a universal adaptation strategy of terrestrial plants to eCO2

Factors associated with loss to follow-up before and after treatment initiation among patients with tuberculosis: A 5-year observation in China

BackgroundLoss to follow-up (LTFU) is a significant barrier to the completion of anti-tuberculosis (TB) treatment and a major predictor of TB-associated deaths. Currently, research on LTFU-related factors in China is both scarce and inconsistent.MethodsWe collected information from the TB observation database of the National Clinical Research Center for Infectious Diseases. The data of all patients who were documented as LTFU were assessed retrospectively and compared with those of patients who were not LTFU. Descriptive epidemiology and multivariable logistic regression analyses were conducted to identify the factors associated with LTFU.ResultsA total of 24,265 TB patients were included in the analysis. Of them, 3,046 were categorized as LTFU, including 678 who were lost before treatment initiation and 2,368 who were lost afterwards. The previous history of TB was independently associated with LTFU before treatment initiation. Having medical insurance, chronic hepatitis or cirrhosis, and providing an alternative contact were independent predictive factors for LTFU after treatment initiation.ConclusionLoss to follow-up is frequent in the management of patients with TB and can be predicted using patients’ treatment history, clinical characteristics, and socioeconomic factors. Our research illustrates the importance of early assessment and intervention after diagnosis. Targeted measures can improve patient engagement and ultimately treatment adherence, leading to better health outcomes and disease control