糖尿病培训手册在培养糖尿病护士的应用

Objective: To explore the nursing service mode for specialized nurses in diabetes and its application effect. Methods:In view of the actual situation of our hospital, a special training manual named with Diabetes training manual was prior composed. 40 specialized nurses in diabetes were trained with the special training manual. Training lasted for 3 months. After the training, the specialized nurses were assessed with the specialty knowledge of Diabetes Mellitus, the skill of clinical procedures, and the knowledge about patients' health education. Results: The skill of the trained nurses was improved. The satisfaction of patients was enhanced.Conclusion: Diabetes training manual can be used for specialized nurses in diabetes.目的  探讨糖尿病护士培训方式。方法  对2013年1—10月本院内分泌科的40名糖尿病护士培训,根据以往医院的培训，结合本院实际，应用自编的糖尿病培训手册，最后考核糖尿病专科理论、操作及宣教能力考核，培训时间为3个月。结果  培训前与培训后比较差别有统计学意义（P＜0.05），理论、操作及健康宣教能力较培训前提高；提高了患者及新护士的满意度。结论  糖尿病培训手册可以用于培养糖尿病新护士

Two variants on T2DM susceptible gene HHEX are associated with CRC risk in a Chinese population

Increasing amounts of evidence has demonstrated that T2DM (Type 2 Diabetes Mellitus) patients have increased susceptibility to CRC (colorectal cancer). As HHEX is a recognized susceptibility gene in T2DM, this work was focused on two SNPs in HHEX, rs1111875 and rs7923837, to study their association with CRC. T2DM patients without CRC (T2DM-only, n=300), T2DM with CRC (T2DM/CRC, n=135), cancer-free controls (Control, n=570), and CRC without T2DM (CRC-only, n=642) cases were enrolled. DNA samples were extracted from the peripheral blood leukocytes of the patients and sequenced by direct sequencing. The χ(2) test was used to compare categorical data. We found that in T2DM patients, rs1111875 but not the rs7923837 in HHEX gene was associated with the occurrence of CRC (p= 0.006). for rs1111875, TC/CC patients had an increased risk of CRC (p=0.019, OR=1.592, 95%CI=1.046-2.423). Moreover, our results also indicated that the two variants of HEEX gene could be risk factors for CRC in general population, independent on T2DM (p< 0.001 for rs1111875, p=0.001 for rs7923837). For rs1111875, increased risk of CRC was observed in TC or TC/CC than CC individuals (p<0.001, OR= 1.780, 95%CI= 1.385-2.287; p<0.001, OR= 1.695, 95%CI= 1.335-2.152). For rs7923837, increased CRC risk was observed in AG, GG, and AG/GG than AA individuals (p< 0.001, OR= 1.520, 95%CI= 1.200-1.924; p=0.036, OR= 1.739, 95%CI= 0.989-3.058; p< 0.001, OR= 1.540, 95%CI= 1.225-1.936). This finding highlights the potentially functional alteration with HHEX rs1111875 and rs7923837 polymorphisms may increase CRC susceptibility. Risk effects and the functional impact of these polymorphisms need further validation

Finding Mixed Nash Equilibria of Generative Adversarial Networks

We reconsider the training objective of Generative Adversarial Networks (GANs) from the mixed Nash Equilibria (NE) perspective. Inspired by the classical prox methods, we develop a novel algorithmic framework for GANs via an infinite-dimensional two-player game and prove rigorous convergence rates to the mixed NE, resolving the longstanding problem that no provably convergent algorithm exists for general GANs. We then propose a principled procedure to reduce our novel prox methods to simple sampling routines, leading to practically efficient algorithms. Finally, we provide experimental evidence that our approach outperforms methods that seek pure strategy equilibria, such as SGD, Adam, and RMSProp, both in speed and quality

Parallel and Convergent Evolution of the Dim-Light Vision Gene RH1 in Bats (Order: Chiroptera)

Rhodopsin, encoded by the gene Rhodopsin (RH1), is extremely sensitive to light, and is responsible for dim-light vision. Bats are nocturnal mammals that inhabit poor light environments. Megabats (Old-World fruit bats) generally have well-developed eyes, while microbats (insectivorous bats) have developed echolocation and in general their eyes were degraded, however, dramatic differences in the eyes, and their reliance on vision, exist in this group. In this study, we examined the rod opsin gene (RH1), and compared its evolution to that of two cone opsin genes (SWS1 and M/LWS). While phylogenetic reconstruction with the cone opsin genes SWS1 and M/LWS generated a species tree in accord with expectations, the RH1 gene tree united Pteropodidae (Old-World fruit bats) and Yangochiroptera, with very high bootstrap values, suggesting the possibility of convergent evolution. The hypothesis of convergent evolution was further supported when nonsynonymous sites or amino acid sequences were used to construct phylogenies. Reconstructed RH1 sequences at internal nodes of the bat species phylogeny showed that: (1) Old-World fruit bats share an amino acid change (S270G) with the tomb bat; (2) Miniopterus share two amino acid changes (V104I, M183L) with Rhinolophoidea; (3) the amino acid replacement I123V occurred independently on four branches, and the replacements L99M, L266V and I286V occurred each on two branches. The multiple parallel amino acid replacements that occurred in the evolution of bat RH1 suggest the possibility of multiple convergences of their ecological specialization (i.e., various photic environments) during adaptation for the nocturnal lifestyle, and suggest that further attention is needed on the study of the ecology and behavior of bats

Temperature and impurity effects of the polaron in an asymmetric quantum dot

We study the temperature and impurity effects of the ground state energy and the ground state binding energy in an asymmetric quantum dot by using the liner combination operator method. It is found that the ground state energy and the ground state binding energy will increase with increasing the temperature. The ground state ener-gy is a decreasing function of the Coulomb bound potential, whereas the ground state binding energy is an in-creasing one of it