Mutual Information Learned Regressor: an Information-theoretic Viewpoint of Training Regression Systems

As one of the central tasks in machine learning, regression finds lots of applications in different fields. An existing common practice for solving regression problems is the mean square error (MSE) minimization approach or its regularized variants which require prior knowledge about the models. Recently, Yi et al., proposed a mutual information based supervised learning framework where they introduced a label entropy regularization which does not require any prior knowledge. When applied to classification tasks and solved via a stochastic gradient descent (SGD) optimization algorithm, their approach achieved significant improvement over the commonly used cross entropy loss and its variants. However, they did not provide a theoretical convergence analysis of the SGD algorithm for the proposed formulation. Besides, applying the framework to regression tasks is nontrivial due to the potentially infinite support set of the label. In this paper, we investigate the regression under the mutual information based supervised learning framework. We first argue that the MSE minimization approach is equivalent to a conditional entropy learning problem, and then propose a mutual information learning formulation for solving regression problems by using a reparameterization technique. For the proposed formulation, we give the convergence analysis of the SGD algorithm for solving it in practice. Finally, we consider a multi-output regression data model where we derive the generalization performance lower bound in terms of the mutual information associated with the underlying data distribution. The result shows that the high dimensionality can be a bless instead of a curse, which is controlled by a threshold. We hope our work will serve as a good starting point for further research on the mutual information based regression.Comment: 28 pages, 2 figures, presubmitted to AISTATS2023 for reviewin

Ubiquitin ligase RNF125 targets PD-L1 for ubiquitination and degradation

As a critical immune checkpoint molecule, PD-L1 is expressed at significantly higher levels in multiple neoplastic tissues compared to normal ones. PD-L1/PD-1 axis is a critical target for tumor immunotherapy, blocking the PD-L1/PD-1 axis is recognized and has achieved unprecedented success in clinical applications. However, the clinical efficacy of therapies targeting the PD-1/PD-L1 pathway remains limited, emphasizing the need for the mechanistic elucidation of PD-1/PD-L1 expression. In this study, we found that RNF125 interacted with PD-L1 and regulated PD-L1 protein expression. Mechanistically, RNF125 promoted K48-linked polyubiquitination of PD-L1 and mediated its degradation. Notably, MC-38 and H22 cell lines with RNF125 knockout, transplanted in C57BL/6 mice, exhibited a higher PD-L1 level and faster tumor growth than their parental cell lines. In contrast, overexpression of RNF125 in MC-38 and H22 cells had the opposite effect, resulting in lower PD-L1 levels and delayed tumor growth compared with parental cell lines. In addition, immunohistochemical analysis of MC-38 tumors with RNF125 overexpression showed significantly increased infiltration of CD4+, CD8+ T cells and macrophages. Consistent with these findings, analyses using The Cancer Genome Atlas (TCGA) public database revealed a positive correlation of RNF125 expression with CD4+, CD8+ T cell and macrophage tumor infiltration. Moreover, RNF125 expression was significantly downregulated in several human cancer tissues, and was negatively correlated with the clinical stage of these tumors, and patients with higher RNF125 expression had better clinical outcomes. Our findings identify a novel mechanism for regulating PD-L1 expression and may provide a new strategy to increase the efficacy of immunotherapy

Design of a Piezoelectric Pump Driven by Inertial Force of Vibrator Supported by a Slotted Beam

This paper introduces the design, manufacture, dynamic analysis, and experimental results of a piezoelectric pump driven by the inertial force of a vibrator supported by a slotted beam. The piezoelectric vibrator is composed of a mass block, displacement amplifier, and slotted beam fixed with both ends. In the resonant mode, the displacement amplifier drives the slotted beam to work, and produces amplitude and inertial force. In this paper, the design of the slotted beam optimizes the output of the displacement amplifier. In addition, the slotted beam supports the displacement amplifier and increases the elastic output. The pump body adopts polydimethylsiloxane (PDMS) check valves and compressible spaces to improve the output performance. This research studies the influence of stiffness and mass on the output performance by qualitatively analyzing the inertial output force of the vibrator. Nine kinds of slotted beams with different stiffnesses and different mass blocks are designed for comparison. Thereafter, an optimal structure of the piezoelectric pump is selected. The experimental results show that under a driving voltage of 700 Vpp , the maximum flowrate is 441 mL min−1 and the maximum back pressure is 25.3 kPa

The Role of Rumination and Stressful Life Events in the Relationship between the Qi Stagnation Constitution and Depression in Women: A Moderated Mediation Model

The qi stagnation constitution is associated with depression in traditional Chinese medicine. It is unclear how rumination and stressful life events affect the relationship between the qi stagnation constitution and depression. The Qi Stagnation Constitution Scale, Ruminative Response Scale, Center for Epidemiologic Studies Depression Scale, and Adolescent Self-Rating Life Events Checklist were used to assess this association in 1200 female college students. The results revealed that the qi stagnation constitution was positively associated with depression. Furthermore, rumination was a partial mediator of the relationship between the qi stagnation constitution and depression. In addition, stressful life events moderated the direct effect and mediating effect of the qi stagnation constitution on depression. These findings indicate that rumination and stressful life events may affect the relationship between the qi stagnation constitution and depression in women

Determination of Pd(II) with flame atomic absorption spectrometry after flow injection on-line microcolumn preconcentration and separation with thiourea-formaldehyde resin immobilized silica gel as packing

635-638A flow injection on-line preconcentration and separation-flame atomic absorption spectrometric method is developed and applied to analysis of trace Pd (II) with thiourea-formaldehyde resin immobilized silica gel as packing. With a sample acidity of 0.2 mol/l HCl, Pd(II ) is effectively preconcentrated on the microcolumn packing and then eluted with thiourea solution. When 0.1 μg/ml of Pd(II) is preconcentrated for 60 s with a sample flow rate of 4.8 ml/min, the system can tolerate 20.0 mg/ml of anion and 5.0 mg/ml of common metal ions. The limit of detection is 1.5 ng/ml with the relative standard deviation being not more than 2.0% . The proposed method has been applied for analysis of metallurgical samples and results are in good agreement with the certified values

Numerical Research on Global Ice Loads of Maneuvering Captive Motion in Level Ice

In level ice, the maneuvering motion of icebreakers has a major influence on the global ice loads of the hull. This study researched the influences of the drift angle and turning radius on the ice loads of the icebreaker Xue Long through a partial numerical method based on the linear superposition theory of ice loads. First, with reference to the Araon model tests performed by the Korea Research Institute of Ships and Ocean Engineering (KRISO), numerical simulations of Araon’s direct motion were carried out at different speeds, and the average deviation between numerical results and model test results was about 13.8%. Meanwhile, the icebreaking process and modes were analyzed and discussed, compared with a model test and a full-scale ship trial. Next, the maneuvering captive motions of oblique and constant radius were simulated to study the characteristics of ice loads under different drift angles and turning radii. Compared with the maneuvering motion model tests in the ice tank of Tianjin University and the Institute for Ocean Technology of the National Research Council of Canada (NRC/IOT), the numerical results had good agreement with the model test results in terms of the variation trend of ice loads and ice–hull interaction, and the influences of drift angle and turning radius on ice resistance and transverse force, which have a certain reference value for sailing performance research and the design of the hull form of icebreaker ships, are discussed

Covert Communication Gains from Adversary's Uncertainty of Phase Angles

This work investigates the phase gain of intelligent reflecting surface (IRS) covert communication over complex-valued additive white Gaussian noise (AWGN) channels. The transmitter Alice intends to transmit covert messages to the legitimate receiver Bob via reflecting the broadcast signals from a radio frequency (RF) source, while rendering the adversary Willie's detector arbitrarily close to ineffective. Our analyses show that, compared to the covert capacity for classical AWGN channels, we can achieve a covertness gain of value 2 by leveraging Willie's uncertainty of phase angles. This covertness gain is achieved when the number of possible phase angle pairs $N=2$. More interestingly, our results show that the covertness gain will not further increase with $N$ as long as $N \ge 2$, even if it approaches infinity

Numerical Research on Global Ice Loads of Maneuvering Captive Motion in Level Ice

In level ice, the maneuvering motion of icebreakers has a major influence on the global ice loads of the hull. This study researched the influences of the drift angle and turning radius on the ice loads of the icebreaker Xue Long through a partial numerical method based on the linear superposition theory of ice loads. First, with reference to the Araon model tests performed by the Korea Research Institute of Ships and Ocean Engineering (KRISO), numerical simulations of Araon’s direct motion were carried out at different speeds, and the average deviation between numerical results and model test results was about 13.8%. Meanwhile, the icebreaking process and modes were analyzed and discussed, compared with a model test and a full-scale ship trial. Next, the maneuvering captive motions of oblique and constant radius were simulated to study the characteristics of ice loads under different drift angles and turning radii. Compared with the maneuvering motion model tests in the ice tank of Tianjin University and the Institute for Ocean Technology of the National Research Council of Canada (NRC/IOT), the numerical results had good agreement with the model test results in terms of the variation trend of ice loads and ice–hull interaction, and the influences of drift angle and turning radius on ice resistance and transverse force, which have a certain reference value for sailing performance research and the design of the hull form of icebreaker ships, are discussed