How Does Targeted Poverty Alleviation Policy Influence Residents' Perceptions of Rural Living Conditions? A Study of 16 Villages in Gansu Province, Northwest China

Rural living conditions (RLCs) in China are influential on the overall development and stability of regions, particularly for populations in distant poverty-stricken villages. This paper takes 16 villages of Chedao town in Gansu province, Northwest China (NWC) as our case study. Using data from the Poverty Alleviation and Assistance (PAA) project launched by Lanzhou University in June 2017, and the perceptions of residents of Chedao, we pinpoint RLC changes in the targeted poverty alleviation (TPA) process. The three main results show that: (1) From the residents' perceptions, the impact of alleviation measures on RLC is mainly reflected in improved housing conditions, infrastructure, and public services. We find no significant effect on cultural conditions. However, eco-environmental conditions have obviously weakened. (2) Housing size, accessibility, distance to shops, and safe drinking water are the most significant factors in housing conditions, infrastructure, public services, and eco-environmental conditions, respectively. (3) Out of the different levels of rural poverty households (RPHs), severe rurality villages are more strongly aware of the positive changes in RLC than residents of mild rurality villages. Moreover, in residents' view, housing conditions are most improved in severe rurality villages, infrastructure is most improved in moderate rurality villages, and public services are most improved in mild rurality villages. Eco-environmental conditions worsen across all levels. Our findings shed light on the perceptions of residents on changes occurring in rural living conditions, and provide a basis for subsequent studies of RLC in Northwest China

Prognostic values of ALDOB expression and 18F-FDG PET/CT in hepatocellular carcinoma

PurposeThe glycolytic enzyme fructose 1,6-bisphosphate aldolase B (ALDOB) is aberrantly expressed and impacts the prognosis in hepatocellular carcinoma (HCC). Hepatic ALDOB loss leads to paradoxical upregulation of glucose metabolism, favoring hepatocellular carcinogenesis. Nevertheless, the relationship between ALDOB expression and 18F-fluorodeoxyglucose (18F-FDG) uptake, and their effects on HCC prognosis remain unclear. We evaluated whether ALDOB expression is associated with 18F-FDG uptake and their impacts on HCC prognosis prediction.MethodsChanges in ALDOB expression levels and the prognostic values in HCC were analyzed using data from The Cancer Genome Atlas (TCGA) database. Ultimately, 34 patients with HCC who underwent 18F-FDG positron emission tomography/computed tomography (PET/CT) preoperatively were enrolled in this retrospective study. ALDOB expression was determined using immunohistochemistry (IHC) staining, and the maximum standardized uptake value (SUVmax) of HCC was calculated from the 18F-FDG PET/CT scans. The relationship between ALDOB expression and SUVmax was examined, and their impacts on overall survival were evaluated using Cox proportional hazards models and Kaplan–Meier survival analysis. ALDOB overexpression in HUH7 and 7721 cells was used to analyze its role in tumor metabolism.ResultsAccording to TCGA database, the ALDOB mRNA level was downregulated in HCC compared to normal tissue, and significantly shortened overall survival in HCC patients. ALDOB protein expression was similarly decreased in IHC findings in HCC than that in adjacent normal tissues (P<0.05) and was significantly associated with tumor size (P<0.001), high tumor-node-metastasis stage (P=0.022), and elevated SUVmax (P=0.009). ALDOB expression in HCC was inversely correlated with SUVmax (r=-0.454; P=0.012), and the optimal SUVmax cutoff value for predicting its expression was 4.15. Prognostically, low ALDOB expression or SUVmax ≥3.9 indicated shorter overall survival time in HCC. Moreover, COX regression analysis suggested high SUVmax as an independent prognostic risk factor for HCC (P=0.036). HCC patients with negative ALDOB expression and positive SUVmax (≥3.9) were correlated with worse prognosis. ALDOB overexpression in HCC cells significantly decreases 18F-FDG uptake and lactate production.ConclusionSUVmax in HCC patients is inversely correlated with ALDOB expression, and 18F-FDG PET/CT may be useful for ALDOB status prediction. The combined use of ALDOB expression and 18F-FDG PET/CT data can provide additional information on disease prognosis in HCC patients

Cannabinoid Receptor Subtype 2 (Cb2R) Agonist Gw405833 Reduces Agonist-Induced Ca2+ Oscillations In Mouse Pancreatic Acinar Cells

Emerging evidence demonstrates that the blockade of intracellular Ca 2+ signals may protect pancreatic acinar cells against Ca 2+ overload, intracellular protease activation, and necrosis. The activation of cannabinoid receptor subtype 2 (CB 2 R) prevents acinar cell pathogenesis in animal models of acute pancreatitis. However, whether CB 2 Rs modulate intracellular Ca 2+ signals in pancreatic acinar cells is largely unknown. We evaluated the roles of CB 2 R agonist, GW405833 (GW) in agonist-induced Ca 2+ oscillations in pancreatic acinar cells using multiple experimental approaches with acute dissociated pancreatic acinar cells prepared from wild type, CB 1 R-knockout (KO), and CB 2 R-KO mice. Immunohistochemical labeling revealed that CB 2 R protein was expressed in mouse pancreatic acinar cells. Electrophysiological experiments showed that activation of CB 2 Rs by GW reduced acetylcholine (ACh)-, but not cholecystokinin (CCK)-induced Ca 2+ oscillations in a concentration-dependent manner; this inhibition was prevented by a selective CB 2 R antagonist, AM630, or was absent in CB 2 R-KO but not CB 1 R-KO mice. In addition, GW eliminated L-arginine-induced enhancement of Ca 2+ oscillations, pancreatic amylase, and pulmonary myeloperoxidase. Collectively, we provide novel evidence that activation of CB 2 Rs eliminates ACh-induced Ca 2+ oscillations and L-arginine-induced enhancement of Ca 2+ signaling in mouse pancreatic acinar cells, which suggests a potential cellular mechanism of CB 2 R-mediated protection in acute pancreatitis

Cumulative exposure to remnant cholesterol and the risk of fragility fractures: a longitudinal cohort study

ObjectiveTo investigate the association between cumulative remnant cholesterol (cumRC) and the risk of new-onset fragility fractures.MethodsThis study included individuals who participated in the 2006, 2008, and 2010 Kailuan health examinations. Baseline characteristics were compared between groups according to cumRC quartiles. The incidence density was calculated, and the log-rank test was used to compare the cumulative incidence. Cox proportional hazards models were used to estimate the hazard ratio (HR) and 95% confidence interval (CI), and restricted cubic spline was used to examine the possibly non-linear relation between cumRC and the risk of fragility fractures. Additional analyses were performed with stratification by age (≥ or <65 years).ResultsA total of 43,839 individuals were included in this study. During the median follow-up period of 10.97 years, a total of 489 fragility fractures occurred. Multivariable Cox proportional hazards regression model 3 showed that the Q1 and Q4 groups versus the Q2 group were associated with a higher HR of fragility fracture (HR 1.61, 95% CI: 1.23–2.11; HR 1.38, 95% CI: 1.06–1.81), and restricted cubic spline regression analysis showed a non-linear relationship between cumRC level and the risk of fragility fractures (POverall association < 0.001, PNon-linear association = 0.001). The association was significant in the age group <65 years but not in the age group ≥65 years. The sensitivity analyses were consistent with the main results.ConclusionsBoth too high and too low cumRC levels were associated with a greater risk of fragility fractures, and this association was more significant in young and middle-aged people

CTpathway: A Crosstalk-Based Pathway Enrichment Analysis Method for Cancer Research

Background: Pathway enrichment analysis (PEA) is a common method for exploring functions of hundreds of genes and identifying disease-risk pathways. Moreover, different pathways exert their functions through crosstalk. However, existing PEA methods do not sufficiently integrate essential pathway features, including pathway crosstalk, molecular interactions, and network topologies, resulting in many risk pathways that remain uninvestigated. Methods: To overcome these limitations, we develop a new crosstalk-based PEA method, CTpathway, based on a global pathway crosstalk map (GPCM) with \u3e440,000 edges by combing pathways from eight resources, transcription factor-gene regulations, and large-scale protein-protein interactions. Integrating gene differential expression and crosstalk effects in GPCM, we assign a risk score to genes in the GPCM and identify risk pathways enriched with the risk genes. Results: Analysis of \u3e8300 expression profiles covering ten cancer tissues and blood samples indicates that CTpathway outperforms the current state-of-the-art methods in identifying risk pathways with higher accuracy, reproducibility, and speed. CTpathway recapitulates known risk pathways and exclusively identifies several previously unreported critical pathways for individual cancer types. CTpathway also outperforms other methods in identifying risk pathways across all cancer stages, including early-stage cancer with a small number of differentially expressed genes. Moreover, the robust design of CTpathway enables researchers to analyze both bulk and single-cell RNA-seq profiles to predict both cancer tissue and cell type-specific risk pathways with higher accuracy. Conclusions: Collectively, CTpathway is a fast, accurate, and stable pathway enrichment analysis method for cancer research that can be used to identify cancer risk pathways. The CTpathway interactive web server can be accessed here http://www.jianglab.cn/CTpathway/ . The stand-alone program can be accessed here https://github.com/Bioccjw/CTpathway

Understanding induced fracture instability based on the Mohr-Coulomb failure criterion

This study aims to investigate the failure mechanism of rock fractures induced by excavation unloading and fluid injection in Singapore Bukit Timah granite. The experimental tests on unloading-induced and injection-induced fracture instability are conducted based on the shear-flow experiments. The tests on unloading-induced fracture instability consist of three groups of experiments: the influences of initial normal stress, shear stress level, and unloading rate. The result shows that reducing initial normal stress, shear stress level and unloading rate slowly can help to prevent the unloading-induced fracture instability. The tests on injection-induced fracture instability consider the effect of fluid overpressure and show that the mechanism of injection-induced fracture instability is similar to the mechanism of unloading-induced fracture instability. The results obtained from both experiments indicate that the mechanism of induced seismicity can be interpreted by the Mohr–Coulomb failure criterion through different approaches of moving and modifying the Mohr circle approaching the failure envelope.Master of Science (Civil Engineering

Using literary texts to teach students' reading comprehension

The term literary text is often used to refer to aesthetic written work with standard language, compelling plots and complicate character development that can appeal to readers. Great literary texts not only entail people to read and write well but also give them the chance to broaden their horizons and perspectives. In the field of education, the study of literary texts allows students to foster critical thinking, develop literacy and cultivate imagination. It has only been since the 1980s that literature has been used in teaching English in English as a Foreign Language (EFL) classroom. Generally speaking, studying literature usually close relates to reading comprehension, which is a multifaceted act of interpreting and understanding what you are reading. In reading classes, the use of literary text has been a matter of concern in teaching process in order to achieve more efficient and more constructive reading comprehension goals. However, there are some problems faced by both teachers and students in the teaching and learning process of acquiring English reading comprehension skills such as misperceptions of literature, restrictions of the curriculum and confusions of text selections. This paper is meant to emphasize the significance of literary texts to teach reading in the EFL class and its effects on improving students’ reading comprehension skills. Based on previous studies of literature, using literary texts to teach reading can be a uniquely powerful instruction method in teaching English in EFL classrooms, particularly in developing students’ reading skills and deepening reading comprehension

A Review of Oil–Solid Separation and Oil–Water Separation in Unconventional Heavy Oil Production Process

Unconventional heavy oil ores (UHO) have been considered an important part of petroleum resources and an alternative source of chemicals and energy supply. Due to the participation of water and extractants, oil–solid separation (OSS) and oil–water separation (OWS) processes are inevitable in the industrial separation processes of UHO. Therefore, this critical review systematically reviews the basic theories of OSS and OWS, including solid wettability, contact angle, oil–solid interactions, structural characteristics of natural surfactants and interface characteristics of interfacially active asphaltene film. With the basic theories in mind, the corresponding OSS and OWS mechanisms are discussed. Finally, the present challenges and future research considerations are touched on to provide insights and theoretical fundamentals for OSS and OWS. Additionally, this critical review might even be useful for the provision of a framework of research prospects to guide future research directions in laboratories and industries that focus on the OSS and OWS processes in this important heavy oil production field

Understanding College Students’ Engagement in Mobile Reading for Sustainability in Education: A Case Study from China

Mobile reading is viewed as a promising pathway to reading with sustainable education goals. At present, there have been many studies on the mobile reading of young readers and their reading comprehension by testing their task-based comprehension, but not much attention has been paid to the mobile reading of college students in China and the factors of reading engagement from readers’ perspectives. With the aim to investigate the factors that affect college students’ engagement in mobile reading, this study used interviews with open-ended questions and followed a qualitative content analysis design with an inductive and exploratory approach. The participants of this study were thirty college students with diverse majors out of three universities in Shanghai, China. They were selected from a pre-questionnaire, and these students (N = 30) were chosen from those who read on mobile devices for less than 2 h on average per day (N = 276). The results revealed that the college students perceived a variety of factors affecting their engagement in mobile reading, including the following: four motivational needs (information needs, academic needs, social needs, emotional needs), reading experience, reading efficacy, and reading strategies. It has been assumed that the most common factor that leads to the engagement of college students in mobile reading is the intention to be entertained. The investigation of this study has different results. Even the students who spent the minimum average time mobile reading used it with diverse needs in mind. Nevertheless, students’ reading experience, reading self-efficacy, and reading strategies indicated that sometimes they had difficulties engaging in mobile reading. These difficulties resulted from an imbalance between their needs and their engagement: whether they obtained what they needed. Considering that mobile reading could be an effective way to assist college students’ independent learning and sustainable development in future, it is necessary to understand the factors of mobile reading and rethink how to avoid difficulties to improve the mobile reading engagement of college students